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Veins
Veins carry blood towards the heart .
They carry de-oxygenated blood.
They have valves to stop the backflow of blood
CARDIO VASCULAR SYSTEM CARDIO VASCULAR SYSTEM 1.HEART 2.BLOOD VESSELS -Arteries -Veins -Capillaries 3.LYMPHATIC VESSELS Blood Vessels Arteries The vessels that carry the blood away from the heart they carry oxygenated blood . They have thicker walls than veins to withstand blood pressure. Capillaries .The smallest arterioles break up to capillaries .one endothelial layer Forms the entire Capillary wall .the average diameter 7um Thermoregulation Thermoregulation Human fetus produces 2x heat per kilo of body weight as the adult. Heat dissipation problem.
Heat is lost by placenta.
Which acts as a heat exchanger.
Maintenance of Body Temperature
No less than 33oC
5oC environment No less than 23oC
Infants have:
Large Body surface ( A) Thin body shell ( k)
Body Volume
Therefore,cannot tolerate a heat gradient (dt/dx).
To maintain body temperature during a minor cold stress: Infant must produce 5x heat per kilo as an adult faced with the same stress Involuntary Response to Cold Stress
Shivering in adults
Nonshivering thermogenesis in infants until 3-6 months of age
Nonshivering Thermogenesis Temperature sensors are in the skin (in newborns particularly the face), the spinal cord and the hypothalamus. Temperature information is processed in the hypothalamus. Norepinephrine (NE) is released in response to cold stress. Result: Vasoconstriction and increased metabolic activity. SKELETAS MUSCLES SERVO MECHANISM BIOLOGICAL RECEPTORS • servomechanism, automatic device used to correct the performance of a mechanism by means of an error-sensing feedback. The term servomechanism properly applies only to systems in which the feedback and error correction signals control mechanical position or one of its derivatives such as velocity or acceleration. •Extrafusal muscle fibers are innervated by alpha motor neurons and generate tension by contracting, thereby allowing for skeletal movement.
Intrafusal muscle fibers are
skeletal muscle fibers that comprise the muscle spindle and are innervated by gamma motor neurons. •These fibers are proprioceptors that detect the amount and rate of change in length of a muscle. Intrafusal fibers are wrapped by two types of afferent endings that send sensory inputs to the CNS •Primary afferent endings (annul spiral endings) •group 1 fibers •Innervate the center of the spindle •Secondary afferent endings(flower spray endings) Type II fibers •Associated with the ends of the spindle MECHANISM : The extrafusal fibers are attached to bone through tendons exhibit a finite spring stiffness which are embedded in Golgi tendon organs These organs are mechanic receptors sensitive to the total muscle tension. Alpha loop control : The tendon organs provides inhibitory feedback to the alpha motor neuron but do not constitute the basic positive feedback element for this servomechanism Loop control • Activating the motor neurons that stimulate the distal ends of the intrafusal fibers to contact thus stretching the mid-portion of the spindle (internal stretch) • Whatever the stimulus, when the spindles are activated their associated sensory neurons transmit impulses at a higher frequency • The spindle to the spinal cells cord primary afferents have an excitatory effect on alpha motor neurons travel via spinal cord in a fast mono synaptic reflex arc