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    Gene Therapy

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    Michaella Saet
    Gene therapy is an experimental technique that uses genes to treat or prevent disease. Researchers were able to restore basic hearing in genetically deaf mice using gene therapy by inserting a healthy gene. They also restored a higher level of hearing in mice equivalent to a whisper. There are ethical issues involving who can access gene therapy and how it may impact society.

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    Gene Therapy

    Uploaded by

    Michaella Saet
    251 views32 pages
    Gene therapy is an experimental technique that uses genes to treat or prevent disease. Researchers were able to restore basic hearing in genetically deaf mice using gene therapy by inserting a healthy gene. They also restored a higher level of hearing in mice equivalent to a whisper. There are ethical issues involving who can access gene therapy and how it may impact society.

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    Powerpoint presentation about gene therapy

    Original Title

    GENE THERAPY

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    Gene therapy is an experimental technique that uses genes to treat or prevent disease. Researchers were able to restore basic hearing in genetically deaf mice using gene therapy by inserting a healthy gene. They also restored a higher level of hearing in mice equivalent to a whisper. There are ethical issues involving who can access gene therapy and how it may impact society.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    251 views32 pages

    Gene Therapy

    Uploaded by

    Michaella Saet
    Gene therapy is an experimental technique that uses genes to treat or prevent disease. Researchers were able to restore basic hearing in genetically deaf mice using gene therapy by inserting a healthy gene. They also restored a higher level of hearing in mice equivalent to a whisper. There are ethical issues involving who can access gene therapy and how it may impact society.

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    © All Rights Reserved
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    You are on page 1of 32

    GENE

    THERAP BSA-2A
    FABIAN, MARK FRANCIS

    Y ESPINO, MARIELA
    SAET, MICHAELLA VANEIREEN
    YUMUL, PAULA
    Medical science has detected
    many human diseases related to
    defective genes. These types of
    diseases are not curable by
    traditional methods like taking
    readily available medicines.
    Gene therapy is a
    potential method to
    either treat or cure
    genetic-related
    human illnesses.
    G
    GEEN
    NEE T
    THHE
    ERRA
    A PP Y
    Y
    -is an experimental technique
    that uses genes to treat or
    prevent disease. In the future,
    this technique may allow
    3 to treat a disorder by
    doctors
    inserting a gene into a patient's
    cells instead of using drugs or
    surgery.
    In 2015, a team of researchers at the
    Harvard Medical School and the Boston
    Children's Hospital stated that they were
    able to restore basic hearing in
    genetically deaf mice using gene
    therapy.
    The Boston Children's Hospital
    research team also reported that they
    have restored a higher level of
    hearing—down to 25 decibels which
    is actually equivalent to a whisper.
    They used an improved gene therapy
    vector developed at the Massachusetts
    Eye and Ear that was identified as
    “Anc80" which enables the transfer of
    genes to the inaccessible outer hair cells
    when introduced into the cochlea
    (Fliesler, 2017).
    HUMA
    It was first
    N Viewed as
    realized in GENE insertion
    1971 when the foreign DNA
    first
    recombinant
    THERA into a
    patient's tissue
    DNA PY that eradicates
    experiments the targeted
    were planned. disease.
    Human
    Human gene
    gene
    therapy
    therapy
    Inspired by the success of
    recombinant DNA technology which
    occurred over the last 20 years.
    THE
    BASIC
    PROCESS
    There are several
    approaches to gene
    therapy. These are the
    following (Fliesler,
    2017):
    THE
    THE BASIC
    BASIC
    PROCESS
    PROCESS
    Replacement of mutated gene that
    causes disease with a healthy copy of
    the gene.
    THE
    THE BASIC
    BASIC
    PROCESS
    PROCESS
    Inactivation of a mutated gene
    that is functioning improperly.
    THE
    THE BASIC
    BASIC
    PROCESS
    PROCESS
    Introducing a new gene into the
    body to help fight a disease.
    A gene cannot be
    directly inserted into
    a human gene or cell.
    A gene is inserted
    into another gene
    using a carrier or
    vector.
    At present, the most common
    type of vectors are viruses that
    have been genetically changed to
    carry normal human DNA.
    Viruses have evolved
    a way of
    encapsulating and
    transporting their
    genes to human cells
    in a pathogenic
    manner (Science
    TWO TYPES OF
    GENE THERAPY
    Somatic gene
    therapy
    Somatic gene therapy involves the
    manipulation of genes in cells that will be
    helpful to the patient but not inherited to
    the next generation (Nimsergern, 1988).
    Germ-line
    gene
    therapy
    Germ-line gene therapy involves the
    genetic modification of germ cells or the
    origin cells that will pass the change on to
    the next generation (Your Genome, 2017).
    STEM CELL
    GENE
    THERAPY
    STEM
    CELLS
    • are mother cells that have the
    potential to become any type of
    cell in the body
    STEM
    CELLS
    • can become cells of the blood,
    heart, bones, skin, muscles, brain,
    among others.
    STEM
    • StemCELLS
    cells are derived from
    different sources. Two of which
    are embryonic and somatic stem
    cells.
    EMBRYONIC
    STEM
    CELLS
    The embryos are usually extras that have
    been created in IVF (in vitro fertilization)
    clinics where several eggs are fertilized in a
    test tube then implanted into a woman
    (Crosta, 2013).
    SOMATIC
    STEM
    CELLS
    • are cells that exist throughout the body
    after embryonic development and are
    found inside of different types of tissue.
    SOMATIC
    STEM
    CELLS
    It is generally thought that adult or somatic stem
    cells are limited in their ability to differentiate
    based on their tissue of origin, but there is some
    evidence to suggest that they can differentiate to
    become other cell types (Crosta, 2013).
    THE
    B I O E TH I CS
    O F G EN E
    T H E
    ER RAPY
    APY
    There are ethical issues involved in
    gene therapy. Some of the inquiries
    cited are (Genetics Home Reference,
    2017):
    1. How can "good" and "bad" uses
    of gene therapy be distinguished?
     
    2. Who decides which traits are
    normal and which constitute a
    disability or disorder?
     
    3. Will the high costs of gene therapy
    make it available only to the
    wealthy?

    4. Could the widespread use of gene


    therapy make society less accepting
    of people who are different?
    5. Should people be allowed to use
    gene therapy to enhance basic
    human traits such as height,
    intelligence, or athletic ability?
    END
    Thank You for
    Listening!
    CREDITS: This presentation template was created by Slidesgo, including icons by
    Flaticon, and infographics & images by Freepik.

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