3 - Diagnosis of Pregnancy

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Diagnosis of pregnancy

The diagnosis of pregnancy


requires a multifaceted approach
using 3main diagnostic tools. these
are:
1-history .
2-Examination .
3-laboratory evaluations and
Early diagnosis of pregnancy is
important for follow up and rule out
other pathologies.
History:
Amenorrhea: in weeks ,months.
Cycle regular ‘irregular ,history of
contraception .
nausea and vomiting, generalize
malaise breast tenderness.
Examination:
Enlarged uterus after bimanual examination.
Breast changes :enlargement and discoloration.
Cervical changes:
-Hegar sign (softening and enlargement of the cervix
-Chadwick’s sign :bluish discoloration of the cervix
from the venous congestion, can be observed by 8-
10weeks.
Currently through the use of
chemical assays and ultrasound
diagnosis can be made early before
any physical sign.
*Laboratory evaluation: many
hormones can be measured to
diagnosis pregnancy. the most
commonly used are Bet-HCG and
progesterone .
HCGis glycoprotein similar in structure
to FSH,LH and TSH.hcg composed of
Alfa and Beta sub units. Alfa subunit is
similar to the Alfa subunit s of FSH, LH,
and TSH. Beta subunit of HCG differs
from the others. It is evident in
maternal urine and serum only after
implantation,8-10days after conception
False+ve due to interference with non-
hcg substances or detection of purified
HCG.

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