KDIGO 2012 Clinical Practice Guideline

ACUTE KIDNEY INJURY

Kidney Disease: Improving Global Outcomes

SECTION 1:
INTRODUCTION &
METHODOLOGY

Kidney Disease: Improving Global Outcomes

 KDIGO AKI GUIDELINE WORK
WorkGROUP
Group Co-Chairs
John A Kellum Norbert Lameire
Pittsburgh, PA Ghent, Belgium

Work Group

Peter Aspelin Charles A Herzog Alison M MacLeod Steven M Opal

Stockholm, Sweden Minneapolis, MN, USA Aberdeen, UK Pawtucket, RI, USA

Rashad S Barsoum Michael Joannidis Ravindra L Mehta Franz Schaefer

Cairo, Egypt Innsbruck, Austria San Diego, CA, USA Heidelberg, Germany

Emmanuel A Burdmann Andreas Kribben Patrick T Murray Miet Schetz

São Paulo, Brazil Essen, Germany Dublin, Ireland Leuven, Belgium

Stuart L Goldstein Andrew S Levey Saraladevi Naicker Shigehiko Uchino

Cincinnati, OH, USA Boston, MA, USA Jo’burg, South Africa Tokyo, Japan

Kidney Disease: Improving Global Outcomes

 CKD EVIDENCE REVIEW
Tufts Center for KidneyTEAM
Disease Guideline Development &
Implementation
Tufts Medical Center, Boston, MA, USA

Katrin Uhlig, MD, MS, Project Director; Director, Guideline Development

Jose Calvo-Broce, MD, MS, Nephrology Fellow
Aneet Deo, MD, MS, Nephrology Fellow
Amy Earley, BS, Project Coordinator

In addition, support and supervision were provided by:

Ethan M Balk, MD, MPH, Program Director, Evidence Based Medicine

Kidney Disease: Improving Global Outcomes

SECTION 2:
AKI DEFINITION

Kidney Disease: Improving Global Outcomes

 AKI DEFINITION

2.1.1: AKI is defined as any of the following (Not Graded):

• Increase in SCr by ≥ 0.3 mg/dl (≥ 26.5 µmol/l) within 48 hours; or

• Increase in SCr to ≥ 1.5 times baseline, which is known or

presumed to have occurred within the prior 7 days; or

• Urine volume <0.5 ml/kg/h for 6 hours

Kidney Disease: Improving Global Outcomes

 STAGING OF AKI
2.1.2: AKI is staged for severity according to the following criteria (Not Graded):

2.1.3: The cause of AKI should be determined whenever possible. (Not Graded)

Kidney Disease: Improving Global Outcomes

 CAUSES OF AKI

Kidney Disease: Improving Global Outcomes

 RISK ASSESSMENT
2.2.1: We recommend that patients be stratified for risk of AKI according to their
susceptibilities and exposures. (1B)

2.2.2: Manage patients according to their susceptibilities and exposures to

reduce the risk of AKI (see relevant guideline sections). (Not Graded)

2.2.3: Test patients at increased risk for AKI with measurements of SCr and
urine output to detect AKI. (Not Graded) Individualize frequency and duration of
monitoring based on patient risk and clinical course. (Not Graded)

Kidney Disease: Improving Global Outcomes

 EVALUATION & GENERAL
MANAGEMENT
2.3.1: Evaluate patients with AKI promptly to determine the cause, with special
attention to reversible causes. (Not Graded)

2.3.2: Monitor patients with AKI with measurements of SCr and urine output to
stage the severity, according to Recommendation 2.1.2. (Not Graded)

2.3.3: Manage patients with AKI according to the stage (see Figure 4) and cause.
(Not Graded)

2.3.4: Evaluate patients 3 months after AKI for resolution, new onset, or worsening
of pre-existing CKD. (Not Graded)
• If patients have CKD, manage these patients as detailed in the KDOQI CKD
Guideline (Guidelines 7–15). (Not Graded)
• If patients do not have CKD, consider them to be at increased risk for CKD
and care for them as detailed in the KDOQI CKD Guideline 3 for patients at
increased risk for CKD. (Not Graded)

Kidney Disease: Improving Global Outcomes

 AKI STAGE
High Risk 1 2 3
Discontinue all nephrotoxic agents when possible
Ensure volume status and perfusion pressure
Consider functional hemodynamic monitoring
Monitor Serum creatinine and urine output
Avoid hyperglycemia
Consider alternatives to radiocontrast procedures
Non-invasive diagnostic workup
Consider invasive diagnostic workup
Check for changes in drug dosing
Consider Renal Replacement Therapy
Consider ICU admission
Avoid subclavian catheters if possible

Kidney Disease: Improving Global Outcomes

SECTION 3:
PREVENTION &
TREATMENT OF AKI

Kidney Disease: Improving Global Outcomes

 HEMODYNAMIC MONITORING
3.1.1: In the absence of hemorrhagic shock, we suggest using isotonic
crystalloids rather than colloids (albumin or starches) as initial management for
expansion of intravascular volume in patients at risk for AKI or with AKI. (2B)

3.1.2: We recommend the use of vasopressors in conjunction with fluids in

patients with vasomotor shock with, or at risk for, AKI. (1C)

3.1.3: We suggest using protocol-based management of hemodynamic and

oxygenation parameters to prevent development or worsening of AKI in high-risk
patients in the perioperative setting (2C) or in patients with septic shock (2C).

Kidney Disease: Improving Global Outcomes

 GLYCEMIC CONTROL & NUTRITIONAL
SUPPORT
3.3.1: In critically ill patients, we suggest insulin therapy targeting plasma glucose
110–149mg/dl (6.1–8.3mmol/l). (2C)

3.3.2: We suggest achieving a total energy intake of 20–30 kcal/kg/d in patients

with any stage of AKI. (2C)

3.3.3: We suggest to avoid restriction of protein intake with the aim of preventing or
delaying initiation of RRT. (2D)

3.3.4: We suggest administering 0.8–1.0 g/kg/d of protein in noncatabolic AKI

patients without need for dialysis (2D), 1.0–1.5 g/kg/d in patients with AKI on RRT
(2D), and up to a maximum of 1.7 g/kg/d in patients on continuous renal
replacement therapy (CRRT) and in hypercatabolic patients. (2D)

3.3.5: We suggest providing nutrition preferentially via the enteral route in patients
with AKI. (2C)

Kidney Disease: Improving Global Outcomes

 THE USE OF DIURETICS IN AKI
3.4.1: We recommend not using diuretics to prevent AKI. (1B)

3.4.2: We suggest not using diuretics to treat AKI, except in the management of
volume overload. (2C)

Kidney Disease: Improving Global Outcomes

 VASODILATOR THERAPY
3.5.1: We recommend not using low-dose dopamine to prevent or treat AKI. (1A)

3.5.2: We suggest not using fenoldopam to prevent or treat AKI. (2C)

3.5.3: We suggest not using atrial natriuretic peptide (ANP) to prevent (2C) or
treat (2B) AKI.

Kidney Disease: Improving Global Outcomes

 GROWTH FACTOR INTERVENTION &
ADENOSINE RECEPTOR ANTAGONISTS
3.6.1: We recommend not using recombinant human (rh)IGF-1 to
prevent or treat AKI. (1B)

3.7.1: We suggest that a single dose of theophylline may be

given in neonates with severe perinatal asphyxia, who are at
high risk of AKI. (2B)

Kidney Disease: Improving Global Outcomes

 PREVENTION OF AMINOGLYCOSIDE-
AND AMPHOTERICIN-RELATED AKI
3.8.1: We suggest not using aminoglycosides for the treatment of infections
unless no suitable, less nephrotoxic, therapeutic alternatives are available. (2A)

3.8.2: We suggest that, in patients with normal kidney function in steady state,
aminoglycosides are administered as a single dose daily rather than multiple-dose
daily treatment regimens. (2B)

3.8.3: We recommend monitoring aminoglycoside drug levels when treatment

with multiple daily dosing is used for more than 24 hours. (1A)

3.8.4: We suggest monitoring aminoglycoside drug levels when treatment with

single-daily dosing is used for more than 48 hours. (2C)

Kidney Disease: Improving Global Outcomes

 PREVENTION OF AMINOGLYCOSIDE-
AND AMPHOTERICIN-RELATED AKI
3.8.5: We suggest using topical or local applications of aminoglycosides (e.g.,
respiratory aerosols, instilled antibiotic beads), rather than i.v. application, when
feasible and suitable. (2B)

3.8.6: We suggest using lipid formulations of amphotericin B rather than

conventional formulations of amphotericin B. (2A)

3.8.7: In the treatment of systemic mycoses or parasitic infections, we

recommend using azole antifungal agents and/or the echinocandins rather than
conventional amphotericin B, if equal therapeutic efficacy can be assumed. (1A)

Kidney Disease: Improving Global Outcomes

OTHER METHODS OF PREVENTION OF
AKI IN THE CRITICALLY ILL
3.9.1: We suggest that off-pump coronary artery bypass graft surgery
not be selected solely for the purpose of reducing perioperative AKI or
need for RRT. (2C)

3.9.2: We suggest not using NAC to prevent AKI in critically ill patients
with hypotension. (2D)

3.9.3: We recommend not using oral or i.v. NAC for prevention of

postsurgical AKI. (1A)

Kidney Disease: Improving Global Outcomes

SECTION 4:
CONTRAST-INDUCED AKI

Kidney Disease: Improving Global Outcomes

CI-AKI: DEFINITION, EPIDEMIOLOGY &
PROGNOSIS
4.1: Define and stage AKI after administration of intravascular contrast media
as per Recommendations 2.1.1–2.1.2. (Not Graded)

• 4.1.1: In individuals who develop changes in kidney function after

administration of intravascular contrast media, evaluate for CI-AKI as
well as for other possible causes of AKI. (Not Graded)

Kidney Disease: Improving Global Outcomes

 ASSESSMENT OF THE
POPULATION AT RISK FOR CI-
4.2.1:
AKI
Assess the risk for CI-AKI and, in particular, screen for pre-existing
impairment of kidney function in all patients who are considered for a procedure
that requires intravascular (i.v. or i.a.) administration of iodinated contrast
medium. (Not Graded)

4.2.2: Consider alternative imaging methods in patients at increased risk for

CI-AKI. (Not Graded)

Kidney Disease: Improving Global Outcomes

 NONPHARMACOLOGICAL
PREVENTION STRATEGIES OF CI-
AKI
4.3.1: Use the lowest possible dose of contrast medium in patients at risk for
CI-AKI. (Not Graded)

4.3.2: We recommend using either iso-osmolar or low-osmolar iodinated

contrast media, rather than high-osmolar iodinated contrast media in patients
at increased risk of CI-AKI. (1B)

Kidney Disease: Improving Global Outcomes

 PHARMACOLOGICAL
PREVENTION STRATEGIES OF CI-
AKI
4.4.1: We recommend i.v. volume expansion with either isotonic sodium chloride
or sodium bicarbonate solutions, rather than no i.v. volume expansion, in patients
at increased risk for CI-AKI. (1A)

4.4.2: We recommend not using oral fluids alone in patients at increased risk of
CI-AKI. (1C)

4.4.3: We suggest using oral NAC, together with i.v. isotonic crystalloids, in
patients at increased risk of CI-AKI. (2D)

4.4.4: We suggest not using theophylline to prevent CI-AKI. (2C)

4.4.5: We recommend not using fenoldopam to prevent CI-AKI. (1B)

Kidney Disease: Improving Global Outcomes

 EFFECTS OF HEMODIALYSIS OR
HEMOFILTRATION
4.5.1: We suggest not using prophylactic intermittent hemodialysis
(IHD) or hemofiltration (HF) for contrast-media removal in patients at
increased risk for CI-AKI. (2C)

Kidney Disease: Improving Global Outcomes

SECTION 5:
DIALYSIS
INTERVENTIONS FOR
TREATMENT OF AKI
Kidney Disease: Improving Global Outcomes
TIMING OF RENAL REPLACEMENT
THERAPY
5.1.1: Initiate RRT emergently when life-threatening changes in fluid,
electrolyte, and acid-base balance exist. (Not Graded)

5.1.2: Consider the broader clinical context, the presence of

conditions that can be modified with RRT, and trends of laboratory tests
—rather than single BUN and creatinine thresholds alone—when
making the decision to start RRT. (Not Graded)

Kidney Disease: Improving Global Outcomes

 CRITERIA FOR STOPPING RENAL
REPLACEMENT THERAPY
5.2.1: Discontinue RRT when it is no longer required, either because
intrinsic kidney function has recovered to the point that it is adequate to
meet patient needs, or because RRT is no longer consistent with the
goals of care. (Not Graded)

5.2.2: We suggest not using diuretics to enhance kidney function

recovery, or to reduce the duration or frequency of RRT. (2B)

Kidney Disease: Improving Global Outcomes

 ANTICOAGULATION
5.3.1: In a patient with AKI requiring RRT, base the decision to use
anticoagulation for RRT on assessment of the patient’s potential risks and
benefits from anticoagulation (see Figure 17). (Not Graded)

• 5.3.1.1: We recommend using anticoagulation during RRT in AKI if a

patient does not have an increased bleeding risk or impaired coagulation
and is not already receiving systemic anticoagulation. (1B)

5.3.2: For patients without an increased bleeding risk or impaired coagulation

and not already receiving effective systemic anticoagulation, we suggest the
following:

• 5.3.2.1: For anticoagulation in intermittent RRT, we recommend using

either unfractionated or low-molecular-weight heparin, rather than other
anticoagulants. (1C)
• 5.3.2.2: For anticoagulation in CRRT, we suggest using regional citrate
anticoagulation rather than heparin in patients who do not have
contraindications for citrate. (2B)

Kidney Disease: Improving Global Outcomes

FIGURE
17
 ANTICOAGULATION
5.3.2 (cont’d): For patients without an increased bleeding risk or impaired
coagulation and not already receiving effective systemic anticoagulation, we
suggest the following:

• 5.3.2.3: For anticoagulation during CRRT in patients who have

contraindications for citrate, we suggest using either unfractionated or
low-molecular-weight heparin, rather than other anticoagulants. (2C)

5.3.3: For patients with increased bleeding risk who are not receiving
anticoagulation, we suggest the following for anticoagulation during RRT:

• 5.3.3.1: We suggest using regional citrate anticoagulation, rather than

no anticoagulation, during CRRT in a patient without contraindications for
citrate. (2C)
• 5.3.3.2: We suggest avoiding regional heparinization during CRRT in a
patient with increased risk of bleeding. (2C)

Kidney Disease: Improving Global Outcomes

 ANTICOAGULATION
5.3.4: In a patient with heparin-induced thrombocytopenia (HIT), all heparin
must be stopped and we recommend using direct thrombin inhibitors (such as
argatroban) or Factor Xa inhibitors (such as danaparoid or fondaparinux)
rather than other or no anticoagulation during RRT. (1A)

• 5.3.4.1: In a patient with HIT who does not have severe liver failure,
we suggest using argatroban rather than other thrombin or Factor Xa
inhibitors during RRT. (2C)

Kidney Disease: Improving Global Outcomes

 VASCULAR ACCESS FOR RRT IN
AKI
5.4.1: We suggest initiating RRT in patients with AKI via an uncuffed
nontunneled dialysis catheter, rather than a tunneled catheter. (2D)

5.4.2: When choosing a vein for insertion of a dialysis catheter in patients with
AKI, consider these preferences (Not Graded):
• First choice: right jugular vein;
• Second choice: femoral vein;
• Third choice: left jugular vein;
• Last choice: subclavian vein with preference for the dominant side.

5.4.3: We recommend using ultrasound guidance for dialysis catheter insertion.

(1A)

Kidney Disease: Improving Global Outcomes

 VASCULAR ACCESS FOR RRT IN
AKI
5.4.4: We recommend obtaining a chest radiograph promptly after placement
and before first use of an internal jugular or subclavian dialysis catheter. (1B)

5.4.5: We suggest not using topical antibiotics over the skin insertion site of a
nontunneled dialysis catheter in ICU patients with AKI requiring RRT. (2C)

5.4.6: We suggest not using antibiotic locks for prevention of catheter-related

infections of nontunneled dialysis catheters in AKI requiring RRT. (2C)

Kidney Disease: Improving Global Outcomes

DIALYZER MEMBRANES FOR RRT IN
AKI
5.5.1: We suggest to use dialyzers with a biocompatible membrane for
IHD and CRRT in patients with AKI. (2C)

Kidney Disease: Improving Global Outcomes

 MODALITY OF RRT FOR
PATIENTS WITH AKI
5.6.1: Use continuous and intermittent RRT as complementary
therapies in AKI patients. (Not Graded)

5.6.2: We suggest using CRRT, rather than standard intermittent RRT,

for hemodynamically unstable patients. (2B)

5.6.3: We suggest using CRRT, rather than intermittent RRT, for AKI
patients with acute brain injury or other causes of increased intracranial
pressure or generalized brain edema. (2B)

Kidney Disease: Improving Global Outcomes

 BUFFER SOLUTIONS FOR RRT
IN PATIENTS WITH AKI
5.7.1: We suggest using bicarbonate, rather than lactate, as a buffer in dialysate
and replacement fluid for RRT in patients with AKI. (2C)

5.7.2: We recommend using bicarbonate, rather than lactate, as a buffer in

dialysate and replacement fluid for RRT in patients with AKI and circulatory shock.
(1B)

5.7.3: We suggest using bicarbonate, rather than lactate, as a buffer in dialysate

and replacement fluid for RRT in patients with AKI and liver failure and/or lactic
acidemia. (2B)

5.7.4: We recommend that dialysis fluids and replacement fluids in patients with
AKI, at a minimum, comply with American Association of Medical Instrumentation
(AAMI) standards regarding contamination with bacteria and endotoxins. (1B)

Kidney Disease: Improving Global Outcomes

 DOSE OF RRT IN AKI
5.8.1: The dose of RRT to be delivered should be prescribed before starting
each session of RRT. (Not Graded) We recommend frequent assessment of the
actual delivered dose in order to adjust the prescription. (1B)

5.8.2: Provide RRT to achieve the goals of electrolyte, acid-base, solute, and
fluid balance that will meet the patient’s needs. (Not Graded)

5.8.3: We recommend delivering a Kt/V of 3.9 per week when using

intermittent or extended RRT in AKI. (1A)

5.8.4: We recommend delivering an effluent volume of 20–25 ml/kg/h for CRRT

in AKI. (1A) This will usually require a higher prescription of effluent volume. (Not
Graded)

Kidney Disease: Improving Global Outcomes

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Kidney Disease: Improving Global Outcomes