PHYSIOLOGICAL CHANGES

DURING PREGNANCY

PRESENTED BY :
MS. HIRAL TRIVEDI
CHANGES IN GENITAL
ORGANS
 Vulva
 Vagina
 Uterus
 Isthmus
 Cervix
 Fallopian Tube
 Ovary
 Vulva
 Oedematous
 More Vascular
 Superficial varicosities may appear
specially in multiparae.
 Labia minora are pigmented and
hypertrophied
 Vagina
 Vaginal walls become hypertrophied,
oedematous and more vascular.
 Increased blood supply of the venous plexus
surrounding the walls
 The length of the anterior vaginal wall is
increased.
 Secretion becomes copious, thin and curdy
white
 pH becomes acidic (3.5-6)
 Uterus
 Non-pregnant state weighs about 60gm, with a
cavity of 5-10 ml and measures about 7.5 cm in
length, at term, weighs 900-1000 gm and
measures 35cm in length
 Changes occur in all the parts of uterus body,
isthmus and cervix.
 Increase in growth and enlargement of the body
of the uterus
Changes in the muscles
(1)Hypertrophy and hyperplasia-occur under
the influence of the hormones-oestrogen
and progesterone
(2)Stretching: The muscle fibres further
elongate beyond 20 weeks due to distension
by the growing foetus. The wall becomes
thinner and at term, measures about 1.5cm
or less.
Arrangement of the muscle fibres
1)Outer longitudinal – follows a hood like
arrangement over the fundus; some fibres are
continuous with the round ligaments
(2) Inner circular – It is scanty and have sphincter
like arrangement around the tubal prifices and
internal os
(3) Intermediate – It is the thickest and strongest
layer arranged in criss-cross fashion through which
the blood vessels run.
Apposition of two double curve muscle fibres give
the figure of ‘8’ form, it called as living ligature.
Vascular system

Uterine artery diameter becomes double

Blood flow increases by eight fold at 20 weeks of
pregnancy.
Vasodilatation is mainly due to estradiol and
progesterone.
Veins become dilated and are valveless.
Numerous lymphatic channels open up.
Vascular changes are most pronounced at the
placental site
Weight

Weight is due to the increased growth of the

uterine muscles, connective tissues and
vascular channels
Shape

­Non pregnant pyriform shape is maintained in

early months.
Becomes globular at 12 weeks.
As the uterus enlarge, the shape once more
becomes pyriform or ovoid by 28 weeks
Changes to spherical beyond 36th week
Position

Normal anteverted positions exaggerated up to 8

weeks
The enlarged uterus may lie on the bladder
Afterwards, it becomes erect, the long axis of the
uterus conforms more is a tendency of ante
version
Primigravidae with good tone of the abdominal
muscles, it is held firmly against the maternal
spine.
Contractions (Braxton-Hicks) : Irregular,
infrequent, spasmodic and painless without
any effect on dilatation of the cervix.
Endometrium : structural and secretory
activity of the endometrium
Isthmus

During the first trimester isthmus

hypertrophies and elongates to about 3
times its original length
Becomes softer
 Cervix
 Hypertrophy and hyperplasia of the elastic and
connective tissues
 Vascularity is increased
 Softening of the cervix (Goodell’s sign)
 Squamous cells also become hyperactive
 Mucosal changes simulate basal cell hyperplasia
or cervical intraepithelial neoplasia (CIN)
 Secretion is copious and tenacious –
physiological leucorrhoea of pregnancy
 Becomes bulky
 Fallopian Tube
 Total length is increased
 Tube becomes congested
 Muscles undergo hypertrophy
 Ovary
 Growth and function of the corpus luteum
reaches its maximum at 8th week
 Hormones-oestrogen and progesterone
secreted by the corpus luteum maintain
the environment for the growing ovum
 Control the formation and maintenance of
decidua of pregnancy
 Inhibit ripening of the follicles
 BREAST CHANGES
 Increased size of the breasts
 Marked hypertrophy and proliferation of the
ducts (oestrogen and progesterone)
 Vascularity is increased
 The nipples become larger, erectile and deeply
pigmented
 Sebaceous glands (5-15) become hypertrophied
and are called Montgomery’s tubercles
 Outer zone of less marked and irregular
pigmented area appears in the second trimester
and is called secondary areola
 Secretion (colostrum) can be squeezed out of
the breast at about 12th week
 CUTANEOUS CHANGES
Face (cholasma gravidarum or pregnancy
mask)
an extreme form of pigmentation around the
cheek, forehead and around the eyes
Breast changes
Abdomen
•Linea nigra : a brownish black pigmented
area in the midline stretching from the
xiphisternum to the symphysis pubis
•Straie graviderum :slightly depressed
linear marks with varying length and breadth
found in pregnancy
Linea nigra
 HEMATOLOGICAL CHANGES
Blood volume
Due to increased vascularity of the enlarging
uterus, Blood volume is markedly raised during
pregnancy
The blood volume starts to increase from about
6th week, expends rapidly thereafter to maximum
40-50% above the nonpregnant level at 30-32
weeks
Plasma Volume
Starts to increase by 6 weeks
Rate of increase almost parallels to that of blood
volume
Reached to the extent of 50%
Total plasma volume increases to the extent of
1.25 litters
RBC And Haemoglobin
The RBC mass is increased to the extent of 20-
30%
Increase demand of oxygen transport during
pregnancy
Disproportionate increase in plasma and RBC
volume produces state of haemodilution (fall in
haemocrit)
Hb fall is about 2 gm.% from the non-pregnant
value.
Leucocytes And Immune System
In the second and third trimester, the action of the
polymorphoneuclear leukocytes may be depressed,
perhaps accounting for the increased susceptibility
of pregnant women to infection
Total plasma protein increases from the normal
180 gm. (non-pregnant) to 230 gm
Due to haemodilution(increase plasma volume), the
plasma protein concentration falls from 7 gm.% to 6
gm.%
Blood Coagulation Factor Pregnancy is a
hypercoagulable state. Plasma fibrinogen (factor
1) increases from the third month of pregnancy
 METABOLIC CHANGES
General Metabolic Changes
Total metabolism is increased due to the needs of
the growing fetus and the uterus
Basal metabolic rate is increased to the extent of
30% higher than that of the average for the non-
pregnant women.
Protein Metabolism
Positive nitrogenous balance throughout pregnancy
At term, the fetus and the placenta contain about
500 gm. of protein and the maternal gain is also
about 500 gm.
Carbohydrate Metabolism
Insulin secretion is increased in response to
glucose and amino acids.
Hyperplasia and hypertrophy of beta cells of
pancreas.
Increased insulin level favours lipogenesis (fat
storage).This mechanism ensures continuously
supply of glucose to the fetus
Fat Metabolism
An average of 3-4 kg of fat is stored during
pregnancy mostly in the abdominal wall, breasts,
hips and thighs
Iron Metabolism
Iron is absorbed in ferrous form from duodenum
and jejunum and is released into the circulation as
transferrin
10 percent of ingested iron is absorbed
Total iron requirement during pregnancy is
estimated approximately 1000mg
In the absence of iron supplementation, there is
drop in haemoglobin, serum iron and serum ferritin
concentration at term pregnancy
Weight Gain
In early weeks, the patient may lose weight
because of nausea and vomiting
During subsequent months, the weight gain is
progressive until the last one or two weeks, when
the weight remains static
The total weight gain during the course of a
singleton pregnancy for a healthy woman
averages 11 kg
Distributed to 1 kg in first trimester and 5 kg each
in second and third trimester
The total weight gain at term is distributed
approximately as :
Reproductive weight Net maternal weight
gain : 6 kg gain : 6 kg

Fetus – 3.3 kg, placenta Increases in blood

– 0.6 kg and liquor – 0.8 volume – 1.3 kg
kg uterus – 0.9 kg and Increases in
breast -0.4 kg, extracellular fluid – 1.2
accumulation of the fat kg
and protein – 3.5 kg
Calcium metabolism and locomotor
system
Relaxation of pelvic ligaments and muscles
occurs because of the influence of estrogen and
relaxtin reaches maximum during last weeks of the
pregnancy
Increased lumber lordosis during later months of
the pregnancy due to enlarged uterus backache
and wadding gait
 SYSTEMIC CHANGES
Respiratory System
Shape of the chest and the circumference increases
in pregnancy by 6 cm
Progressive increase in oxygen consumption, which is
caused by the increased metabolic needs of the
mother and fetus
The mucosa of the nasopharynx becomes
hyperaemic and oedematous
 A state of hyperventilation occurs
during pregnancy leading to increase
tidal volume
 The woman feels shortness of breath
 Pregnancy is a state of respiratory
alkalosis
 CARDIOVASCULAR CHANGES
The Heart :
muscle, particularly the left ventricles,
hypertrophies leading to enlargement of the heart
The growing uterus pushes the heart upward and
to the left
During pregnancy the heart rate and stroke
volume (the amount of the blood pumped by heart
with each beat) increases due to the increase
blood volume and oxygen requirement of the
maternal tissues and growing fetus
Cardiac Output :
increases markedly by the end of the first
trimester.
In the third trimester, a rise, fall or no change at
all has been showed to occur, depending on
individual variables.
lowest in the sitting or supine position and
highest in the right or left lateral or knee chest
position.
.
 The capacity of veins and venules
increases.
 Arterial walls relax and dilate due to the
effect of progesterone. The increase
production of vasodilator prostaglandin
also contributes to this
Blood Pressure
During the mid-trimester, changes in blood
pressure may occur causing fainting
In later pregnancy, hypotension may occur in
10% of women in unsupported supine position.
This termed as “supine hypotensive syndrome”
The pressure of gravid uterus compresses the
vena cava, reducing the venous return
Cardiac output is reduced by 25-30 percent and
the blood pressure may fall by 10-15 percent
Regional Distribution Of The Blood Flow
Uterine blood flow is increased from 50 ml per
minute in non-pregnant state about 750 ml near
term
Pulmonary blood flow (normal 6000ml/min) is
increased by 2500 ml per minute
Renal blood flow (normal 800 ml) increases by
400 ml per minute at 16th week remains at this
level till term
Heat sensation, sweating or stuffy nose
complained by the pregnant women can be
explained by the increased blood flow
Urinary System
•kidney
Dilatation of the ureter, renal pelvis and calyces.
The kidneys enlarge in length by 1 cm.
Renal plasma flow is increased by 50-75%,
maximum by the 16 weeks and is maintained until
34 weeks. Thereafter it falls by 25%.
Glomerular filtration rate (GFR) is increased by
50% all throughout the pregnancy
•.
• Ureter
 ureter become atonic due to high
progesterone level.
 Dilatation of the ureter above the pelvic
brim with stasis is marked on the right side
specially in primigravidae
• Bladder
 Increased frequency of micturition is noticed at
6-8 weeks of pregnancy which subside after 12
weeks and In late pregnancy, frequency of
micturition once more reappears due to
pressure on the bladder as the presenting part
descends down the pelvis.
 Stress incontinence may observe in late
pregnancy due to urethral sphincter weakness
Alimentary System
Gums become congested and spongy and may
bleed to touch
Risk of peptic ulcer disease is reduced.
Atonicity of the gut leads to constipation

•Liver and gall bladder

Liver functions are depressed
High blood cholesterol level during pregnancy,
favour stone formation
NERVOUS SYSTEM
Temperamental changes are found during
pregnancy and in the puerperium
Nausea, vomiting, mental irritability and
sleeplessness are probably due to some
psychological background
Postpartum blues, depression or psychosis may
develop in a susceptible individual
 CHANGES IN THE ENDOCRINE
SYSTEM
Placental Hormones
Placenta produces several hormones
The high levels of estrogen and progesterone
produced by the placenta are responsible for breast
changes, skin pigmentations and uterine enlargement
in the first trimester
Chorinonic gonadotrophin is the basis for the
immunologic pregnancy tests
Human placental lactogen stimulates the growth of
the breasts
Pituitary Hormones
The secretion of prolactin, adrenocorticotrophic
hormone, thyrotrophic hormone and melanocyte-
stimulating hormone increases
Follicle stimulating hormone and luteinzing
hormone secretion is greatly inhibited by placental
progesterone and estrogen.
 The effects of prolactin secretion are
suppressed during pregnancy
 Posterior pituitary gland releases oxytocin
in low-frequency pulses throughout
pregnancy. At term the frequency of
pulses increases which stimulates uterine
contractions
Thyroid Function
Gland increases in size by about 13 percent due
to hyperplasia of glandular tissue and increased
vascularity
Increased uptake of iodine during pregnancy
Pregnancy can give the impression of
hyperthyroidism, thyroid function is basically
normal
The basal metabolic rate is increased mainly
because of increased oxygen consumption by the
fetus and the work of the maternal heart and lungs
 • RESEARCH EVIDANCE ON
PHYSIOLOGICAL CHANGES DURING
PREGNANCY
•  
• Anatomical, physiological and metabolic changes
with gestational age during normal pregnancy : a
database for parameters required in
physiological based pharmacokinetic modeling.
          
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