Seizure Disorders in Children: (Febrile Convulsion)

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SEIZURE DISORDERS IN

CHILDREN
(FEBRILE CONVULSION)
Causes of Seizure:
Convulsion with fever Convulsion
without fever
• Febrile convulsion • Epilepsy
• Acute meningitis- • Encephalopathy eg.
bacterial or viral Hypertensive, hepatic or
• Cerebral malaria uraemic, hypoxic, ischaemic
• Viral encephalitis • Trauma eg. Head injury
• Tubercular • Acute stroke syndrome
meningitis(TBM) • ICSOL
• Brain abscess • Metabolic abnormalities
( hypoglycaemia, hypo-
hypernatremia)
FEBRILE CONVULSION
• Febrile seizures are a common cause of
convulsions in young children.

• Convulsion that occur due to extra cranial


infection.

• Occurs due to temporary impairment of the


balance between the convulsant and
anticonvulsant system of the brain.
Criteria of Simple Febrile Seizure
• Age: Usually 6 mo – 6 years of age
– Peak occurrence is in children 18 - 24
months of age
• Males are affected slightly more.
• Family history positive.( Autosomal dominant)
• Convulsion occurs due to rapid rise of
temperature.
• Seizure mostly occurs at around >38˚C or
>101˚F.
Cont’d…..
• Seizures are mostly GTCS type.
• Usually occurs once in 24 hours & within early
hours of illness.
• Lasts for few seconds to few minutes; <15
minutes.
• No residual neurodefecit except for brief
period of drowsiness.
• Absence of signs of meningitis.
• Recurrence: 50% under 1 year & 30% in other
situation up to 5 years.
Complex febrile seizure

– Lasts 15 minutes or longer


– Occurs more than once in a 24-hour period
– Focal or unilateral in nature
– Patient has known neurologic problems,
such as cerebral palsy
– EEG remain abnormal for 2 weeks or more
following the attack.
CLINICAL EVALUATION
A. History:
• Age
• Seizure: type, duration, post ictal phase.
• Fever: nature
• Family history
• Developmental status
B. Physical Examination:
• ABC
• Level of consciousness
• Signs of meningeal irritation
• Anterior fontanelle
• Other systems for foci of infection
Investigations
1. CSF study:
• To rule out meningitis,not indicated in all cases.
• Depends upon the clinical experience &
judgment of the clinician concerned.
Indications for CSF study in FS:
1. Any doubt of meningitis
2. Age < 1 year
3. Associated with complex seizure or altered
sensorium
4. Slow recovery or prolonged post- ictal phase
Inv. for Cause of Fever & Convulsion
1. RBS - ↓
2. S. Electrolytes -↓ or ↑ Na
3. S. Calcium - ↓
4. CBC, PBF, C/S
5. Urine R/M/E , C/S
6. CXR
7. Throat swab C/S
8. EEG: not recommended in SFS.
9. Neuro-imaging: No role
Treatment
• Explanation & reassurance of parents
• Removal of excess clothing.
• Tepid sponging
• Antipyretic-
Paracetamol (15mg/kg/dose ) 4-6 hrly
• Anti-convulsant:
Inj. Diazepum (0.5 mg/kg/dose P/R or
0.3mg/kg/dose IV very slowly)
OR
Inj. Midazolam (0.2mg/kg) smeared on buccal mucosa
or intra-nasally
Prophylaxis for Recurrence
• Generally prophylaxis (continuous or intermittent) not
recommended in Simple FS.
• Intermittent prophylaxis can only be given if parents are
very anxious till 5 years.
1. Tepid sponging
2. Paracetamol 4-6 hry
3. Tab. Diazepum:(0.5-1mg/kg/day in 3 divided doses for
48-72 hrs
OR
Tab Clobazam: 1 mg/kg/dose single or BD dose for
48-72 hrs
AAP Practice Parameter
• "Based on the risk and benefits of effective
therapies, neither continuous nor
intermittent anticonvulsive therapy is
recommended for children with one or more
simple febrile seizures. The American
Academy of Pediatrics recognizes that
recurrent episodes of febrile seizures can
create anxiety in some parents and their
children and as such appropriate educational
and emotional support should be provided"
Criteria for Prophylactic Anticonvulsant
Therapy:

• Patients under 18 months of age with previous


abnormal development or abnormal
neurological signs.
• Atypical febrile seizure
• Recurrent febrile seizure
• High level of parental anxiety
Prognosis
• Benign condition leaving behind no
death or neuro-disability.
• No adverse effect on academic or
behavioural activity.
• Can recur in 1/3rd cases.
• Chance of epilepsy 2-5%.
THANK YOU

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