Approach To Anemia: Bisrat D
Approach To Anemia: Bisrat D
Approach To Anemia: Bisrat D
Bisrat D.
Normal Red Cells
No nucleus, enzyme
packets
Biconcave discs – Haem +
Gl
Center 1/3 pallor
Pink cytoplasm (Hb filled)
Cell size 7- 8 µ - capill. 2 µ
Na less, K more inside
100-120 days life span
The Factory – Bone Marrow
Important to remember
• Anemia is a clinical sign of disease
• Most common hematological disorder
by far
• Almost always a secondary disorder
• It is not a single disease by itself
• Its diagnosis is not that simple !! We’ll
make it
Mechanism
• 3 major physiologic mechanisms cause anemia
MCV
• This may pose a special problem b/c if the antibody involved is unspecific, all
the blood units cross-matched will be incompatible (presence of auto Ab
directed at a core component of Rh locus, w/ch is present on RBCs of all
potential donors, regardless of Rh subtype).
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Complications
• High-output cardiac failure
• End-organ ischemia or infarct, including
o Myocardial infarction
o Stroke
• Hypovolemic shock
• Death