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    Alzheimer's Disease: Roehampton University

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    The document presents a research project on Alzheimer's disease. It discusses the impact of the disease, including psychological and physical effects. It also examines current pharmacological treatments like Aducanumab and Donepezil, and non-pharmacological treatments such as brain training games and memory aids. The conclusion recommends combining Donepezil with non-pharmacological treatments to help lessen symptoms. The document is presented as a report with sections for introduction, thesis, body, conclusion, and references.

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    Alzheimer's Disease: Roehampton University

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    27 views10 pages
    The document presents a research project on Alzheimer's disease. It discusses the impact of the disease, including psychological and physical effects. It also examines current pharmacological treatments like Aducanumab and Donepezil, and non-pharmacological treatments such as brain training games and memory aids. The conclusion recommends combining Donepezil with non-pharmacological treatments to help lessen symptoms. The document is presented as a report with sections for introduction, thesis, body, conclusion, and references.

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    The document presents a research project on Alzheimer's disease. It discusses the impact of the disease, including psychological and physical effects. It also examines current pharmacological treatments like Aducanumab and Donepezil, and non-pharmacological treatments such as brain training games and memory aids. The conclusion recommends combining Donepezil with non-pharmacological treatments to help lessen symptoms. The document is presented as a report with sections for introduction, thesis, body, conclusion, and references.

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    Download as pptx, pdf, or txt
    27 views10 pages

    Alzheimer's Disease: Roehampton University

    Uploaded by

    Only Lonly
    The document presents a research project on Alzheimer's disease. It discusses the impact of the disease, including psychological and physical effects. It also examines current pharmacological treatments like Aducanumab and Donepezil, and non-pharmacological treatments such as brain training games and memory aids. The conclusion recommends combining Donepezil with non-pharmacological treatments to help lessen symptoms. The document is presented as a report with sections for introduction, thesis, body, conclusion, and references.

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    Roehampton

    university

    Alzheimer’s
    disease
    Research project
    Date June 20, 20XX
    Rihab Laaouaj
    LAA22518822
    Content:
     Introduction/ Thesis statement.

     Impact of Alzheimer's disease.

     Alzheimer's treatment.

     Conclusion.

     Reference list.
    Introduction
    :
     Alzheimer’s disease (AD) is the most
    frequent cause of dementia

     More than 850,000


    (Alzheimer’s individuals with
    Society,2022)
    AD in the UK.
    (Alzheimer's disease facts and figures 2019)
    Thesis statement:

     This presentation will argue that …

    28th June 2022 LAA22518822 4


    Impact of AD:
    1- Psychological 2 - Physical
    effect:
     Depression
    effects:
    (Perel, 1998)

     Changes in mood  Inhaling food


    ◦
    (Alzheimer's disease facts and
    figures, 2009)
     Fluids into their lungs

    28th June 2022 LAA22518822 5


    Alzheimer's treatment
    1-Pharmacological treatments:
    Aducanumab :
     An effective treatment with 20%  rate of success.
    (Servick, 2022)
     Costs nearly 150 000 US dollar .
    (Ross, Weinberg and Arnold, 2022)

    Donepezil :
     Its dropout instances made up (5%–13%)
    (Cacabelos, 2022)
     Side effects: difficulty controlling urination and weight loss.
    (Donepezil - Medicine - NHS, 2022)

    28th June 2022 LAA22518822 6


    Alzheimer's treatment
    2-Non-Pharmacological treatments:
     -Brain training games: minimise mental decline.
    (non-drug interventions for Alzheimer’s disease, 2022)

    -Reality Orientation: founded on the theoretical principles of mental functioning.


    (Camargo, Justus and Retzlaff, 2015)

    -Memory aids: improve cognition.


    (Zucchella et al., 2018)

     They are effective with early-stage of AD.


    (Ballard, Khan, Clack and Corbett, 2011)

    28th June 2022 LAA22518822 7


    Conclusion:
    The best way to lessen symptoms quickly:

    Combining Donepezil (pharmacological treatment) with nonpharmacological


    treatment.

    28th June 2022 LAA22518822 8


    References:
    Alzheimer's & Dementia, 2019. 2019 Alzheimer's disease facts and figures. [online] 15(3), pp.321-387. Available at:
    <https://alzjournals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2019.01.010> [Accessed 17 June 2022].

    Alzheimer's Society. 2022. Alzheimer's Society Annual Conference 2022. [online] Available at: <https://www.alzheimers.org.uk/dementia-professionals/conferences-and-events/annual
    conference> [Accessed 17 June 2022].

    Gehrman, P., Gooneratne, N., Brewster, G., Richards, K. and Karlawish, J., 2018. Impact of Alzheimer disease patients' sleep disturbances on their caregivers. Geriatric Nursing, [online] 39(1),
    pp.60-65. Available at: <https://www.sciencedirect.com/science/article/pii/S0197457217301568> [Accessed 17 June 2022].

    Alzheimer's &amp; Dementia, 2009. 2009 Alzheimer's disease facts and figures. [online] 5(3), pp.234-270. Available at: <https://alz-journals.onlinelibrary.wiley.com/doi/pdfdirect/10.1016/
    j.jalz.2009.03.001> [Accessed 17 June 2022].

    Servick, K., 2022. Alzheimer's drug approved despite doubts about effectiveness. [online] Science.org. Available at: <https://www.science.org/content/article/alzheimer-s-drug-approved-despite-
    doubts-about-effectiveness> [Accessed 17 June 2022].

    Ross, E., Weinberg, M. and Arnold, S., 2022. Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US. JAMA Neurology, 79(5), p.478. Available at:
    https://jamanetwork.com/journals/jamaneurology/article-abstract/2790531[Accessed 17 June 2022].

    Cacabelos, R., 2022. Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics. [online] PubMed Central (PMC). Available at:
    <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654795/> [Accessed 17 June 2022].

    nhs.uk. (2020). Donepezil - Medicine - NHS. [online] Available at: https://www.nhs.uk/medicines/donepezil/#:~:text=Donepezil%20is%20a%20medicine%20th> [Accessed 17 June 2022].

    Ncbi.nlm.nih.gov. 2022. Non-drug interventions for Alzheimer’s disease. [online] Available at: <https://www.ncbi.nlm.nih.gov/books/NBK279355/#:~:text=Non%2Ddrug%20interventions
    %20for%20Alzheimer's%20disease%20include%20things%20like%20memory,performance%20and %20increase%20their%20independence.> [Accessed 17 June 2022].

    Camargo, C., Justus, F. and Retzlaff, G., 2015. The Effectiveness of Reality Orientation in the Treatment of Alzheimer’s Disease. American Journal of Alzheimer's Disease
    &amp; Other Dementiasr, [online] 30(5), pp.527-532. Available at: <https://journals.sagepub.com/doi/full/10.1177/1533317514568004> [Accessed 17 June 2022].

    Zucchella, C., Sinforiani, E., Tamburin, S., Federico, A., Mantovani, E., Bernini, S., Casale, R. and Bartolo, M., 2018. The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A
    Narrative Review of Non-Pharmacological Treatment. Frontiers in Neurology, [online] 9. Available at: <https://www.frontiersin.org/articles/10.3389/fneur.2018.01058/full> [Accessed 17 June
    2022].

    Ballard, C., Khan, Z., Clack, H. and Corbett, A. (2011). Nonpharmacological Treatment of Alzheimer Disease. The Canadian Journal of Psychiatry, 56(10), pp.589–595.
    doi:10.1177/070674371105601004. Available at: https://pubmed.ncbi.nlm.nih.gov/22014691/ [Accessed 17 June 2022].

    28th June 2022 LAA22518822 9


    Thank you

    28th June 2022 LAA22518822 10

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