Salivary gland diseases are multiple and varied in etiology:

1-Congenital disorders
2. Salivary calculi
3- Vascular disease
4- Cysts of salivary glands
5- Infection diseases
6- Sialadenosis
7- Irradiation damage
8- Autoimmune disease
CONGENITAL: These disorders of the salivary glands are rare, but
may include: Aplasia, atresia, and ectopic salivary gland tissue.
SALIVARY CALCULI (sialolith):
-Salivary calculi or a stone can form in a salivary gland or duct.
- At least 80% of calculi form in the submandibular gland.
- Several possibly coexisting factors have been suggested to be
involved in the formation of salivary stones, including altered
acidity of saliva, reduced salivary flow rate, abnormal calcium
metabolism and abnormalities in the sphincter mechanism of the
duct opening,
- The exact cause in many cases is unknown.
VASCULAR DISEASE:
Necrotizing sialometaplasia
-Is ulcerative lesion; the ulcer is deep well-circumscribed, usually
located towards the back of the hard palate.
- It is thought to be caused by ischemic necrosis (death of tissue due to
lack of blood supply) of minor salivary glands in response to trauma.
- Often painless, the condition is self-limiting and should heal in
6–10 weeks.
Although entirely benign and requiring no treatment, due to its similar
appearance to oral cancer, it is sometimes misdiagnosed as malignant.
Therefore, it is considered an important condition, despite its rarity.
Differentiation between this and squamous cell carcinoma ulcer would
be based on a history of recent trauma or dental treatment in the area
like local anesthetic injections

Ductal structures undergo transformation from cuboidal to squamous cells

(squamous metaplasia)
CYSTS OF SALIVARY GLANDS: Mucoceles and ranula

INFECTION DISEASES:
Infections can be viral or bacterial (or rarely fungal).
A. Viral sialadenitis:

Mumps
-Is caused by paramyxovirus which causes painful swelling of the
parotids and sometimes other glands.
- It is highly infectious and is the most common cause of acute
parotid swelling.
- Children are mainly affected
- The virus is transmitted by direct contact with infected saliva and
by droplet spread.
CLINICAL FEATURES
-An incubation period of about 21days is followed by headache,
malaise, fever and tense, painful and tender swelling of the parotids.
-The salivary glands enlargement gradually subsides over a period
of about seven days.
-In adults other organs are involved such as testes, ovaries, central
nervous system and pancreas, and orchitis is the most common
complication.
-Mumps may be mistaken for a dental infection or bacterial
sialadenitis, if unilateral.
B. Bacterial sialadenitis:
- Present as an acute or chronic condition

- Acute bacterial sialadenitis particularly involves the parotid

glands and traditionally affected debilitated patients, particularly
postoperatively, as a result of xerostomia secondary to dehydration.
- It is more commonly seen in patients with severe xerostomia,
particularly Sjogren's syndrome, and as an uncommon complication
of drugs that cause xerostomia.
- It is usually caused by ascending organisms from the oral cavity.
Important bacterial causes include Staphylococcus aureus and
streptococcus pyogenes.
clinical features

-Typical clinical features are pain in one or both parotids with

swelling, redness and tenderness and often increasing malaise and
fever.

- The regional lymph nodes are enlarged and tender, and pus exudes or
can be expressed from the parotid duct.
Microscopically
An intense acute inflammatory infiltrate extends into the periductal
tissues is seen.
Chronic bacterial sialadenitis
- Is usually a complication of duct obstruction, or due to decreased
salivary flow with low grade ascending infection.
- Mostly unilateral and associated with recurrent painful swelling
of the gland.
- The submandibular gland is much more commonly affected, and
the duct orifice may appear inflamed and red.
- Sialography may show dilatation of ducts (sialectasia) behind the
obstruction.
. Microscopically
- Varying degrees of destruction of acini, duct dilatation and a
scattered chronic inflammatory cellular infiltrate, and interstitial
fibrosis are seen.

Chronic bacterial sialadenitis, severe acinar atrophy

with infiltrate of lymphocytes and plasma cells.
SIALADENOSIS (sialosis):
- Chronic, bilateral, diffuse, non-inflammatory, non-neoplastic
enlargement of a salivary gland, usually the parotid gland ,but
occasionally affects the submandibular glands.
- This can be painless or in some instances tender.
- Sialosis may be idiopathic or may be associated with the chronic
malnutrition, obesity, diabetes mellitus, alcoholism, liver disease, or
drugs (like antihypertensives)
Microscopically
- Fatty infiltration in the glandular stroma is seen.

- Salivary gland enlargement usually resolves with treatment of the

underlying condition.
IRRADIATION DAMAGE:
- Salivary tissue is highly sensitive to ionizing radiation.
- Irreversible destruction of acini and fibrous replacement can result
from therapeutic radiation of the head and neck.
- Xerostomia with its attendant complications, such as rampant dental
caries, is the typical result.
AUTOIMMUNE DISEASE:

Sjögren's syndrome is autoimmune disease and divided into:

 Primary Sjogren's syndrome (Sicca syndrome) which comprises
dry mouth and dry eyes and not associated with any connective
tissue disease.
 Secondary Sjogren's syndrome comprises dry mouth and dry eyes
and associated with rheumatoid arthritis or other connective tissue
disease.
CLINICAL FEATURES
-Females are affected nearly 10 times as frequently as males.
- Salivary glands enlargement is variable.
- About half of the cases shows bilateral enlargement which
predominantly affect the parotid glands, and seldom painful.
- In established cases the oral mucosa is obviously dry, often red, and
shiny.
- The tongue is typically red and the papillae show atrophy.
Microscopically
- Histopathological examination of involved major glands shows acinar
atrophy and lymphocytic infiltration which eventually replaced the
whole affected lobules

Dense, well-defined foci of lymphocytes surround the larger ducts in the centre of
the lobules with complete acinar atrophy and a rim of residual salivary
parenchyma remains around the periphery of the lobule.
SALIVARY GLAND TUMORS
-Tumors of the salivary glands comprise a significant proportion of
oral tumors, and are the next most common neoplasms of the mouth
after squamous cell carcinoma.
-However, tumors of the minor intraoral salivary glands are less
common than in the major salivary glands
- About 70% of salivary gland tumors develop in the parotid
- Over 75% of salivary gland tumors are benign.
The WHO histological classification of tumors of the salivary glands
and the typical clinical features of salivary gland tumors are seen in
Table-1and Table-2.
The typical clinical features of salivary gland tumors .
 BENIGN TUMORS OF SALIVARY GLANDS

PLEOMORPHIC ADENOMA (Mixed tumor)

- It is the most common benign neoplasm.
- The term ‘pleomorphic adenoma’ is due to the unusual histologic
pattern.
- Ductal and myoepithelial cells in possibly either or both may play
active roles in the histogenesis of the tumor.
.
Clinical features:
- Pleomorphic adenoma is the most common tumor of salivary
glands.
- The parotid gland is the most common site of the pleomorphic
adenoma .
- Approximately about 8% of pleomorphic adenomas involve the
minor salivary glands and the palate is the most common site of
minor salivary gland involvement and glands of the lip and
occasionally other sites.
- It occurs more frequently in females than in males.
- The majority of the lesions are found in patients in the fourth to
sixth decades, but they are also relatively common in young adults
and have been known to occur in children.
- The history presented by the patient is usually that of a small,
painless nodule which slowly begins to increase in size, sometimes
showing intermittent growth.
- The pleomorphic adenoma, particularly of the parotid gland, is
typically a lesion that does not show fixation either to the deeper
tissues or to the overlying skin
- Rubbery in consistency.
- The skin seldom ulcerates
- pain is not a common symptom
- facial nerve involvement manifested by facial paralysis is rare.
Histopathological features :
- The tumor is usually surrounded by capsule which varies in
thickness and presence,
- The tumor sometimes bulges through the capsule, and this may
cause recurrence after its surgical removal.
- For this reason the tumor must excised with a margin of surrounding
normal tissue.

Tumor nodule within the capsulate

- The epithelium usually forms sheets or duct-like structures.
- The ducts show cuboidal luminal cells, and often contain
eosinophilic secretory material.
- Squamous metaplasia and sometimes with the formation of keratin
pearls can be seen.
- Myoepithelial cells may form a fine reticular pattern or sheets of
spindle-shaped cells.
- The mesenchymal-like component is myxoid or cartilaginous and
sometimes this tissue forms the bulk of the tumor.
- Bone may form within this cartilage or form directly by osseous
metaplasia of the stroma.
- Malignant transformation may occur, usually in tumors that have
been present for many years.
Histopathological features:
- The lesion is essentially an adenoma exhibiting cyst formation.
- It contains papillary projections into the cystic spaces.
- The papillae have fibrovascular cores often with a lymphoid matrix
showing germinal centers.
- The epithelium comprises two layers of cells: the columnar and
deep to this layer is the cuboidal basal cells.
- The cystic spaces contain eosinophilic secretions.
- The tumor is surrounded by sharply demarcated thin capsule.
CANALICULAR ADENOMA
Clinical features:
- Canalicular adenoma is an uncommon neoplasm originates
mainly in the intraoral accessory salivary glands, and in the vast
majority of cases, it occurs in the upper lip (about 80% of cases).
However, cases are known in which the lesion occurred in the
palate, buccal mucosa and lower lip.
- The tumor occurs in old patients
- Seen more commonly in females.
Histopathological features:
- It is composed of long columns or cords of cuboidal or columnar
cells in a single layer.
- These single layers of cells are parallel, forming long canals.
- In some instances, cystic spaces of varying sizes are enclosed by
these cords.
- The cystic spaces are usually filled with an eosinophilic
coagulum. - The supporting stroma is loose with delicate
vascularity.
- Some canalicular adenomas have a fibrous capsule.
MALIGNANT TUMORS OF SALIVARY GLANDS
MUCOEPIDERMOID CARCINOMA
Mucoepidermoid carcinoma is the most common epithelial malignant
neoplasm observed in the major and minor salivary glands.
Clinical features.
- The parotid gland is the most common site of occurrence.
- Intraorally, it shows a strong predilection for the palate.
- It occurs with a slight female predilection
- Mostly old age patients affected, but can occur in any age.
- It is the most common malignant salivary gland tumor of children.
- The tumor grows rapidly and facial nerve paralysis is frequent in
parotid tumors.
- The patient may also complain of trismus, dysphagia, numbness of
the adjacent areas, ulcerations and pain.
- The mucoepidermoid carcinoma is not encapsulated, and tends to
infiltrate the surrounding tissue, and in a large percentage of cases,
it metastasizes to regional lymph nodes.
- Distant metastases to lung, bone, brain
and subcutaneous tissues are also common.
Histopathological features:
- The mucoepidermoid carcinoma is composed of epidermoid type
(squamous) cells, mucous secreting cells, and intermediate cells.
- The mucous cells are of various shapes and have abundant, pale,
foamy cytoplasm.
- A population of cells is referred to as the intermediate cells are
larger than basal cells and smaller than the squamous cells are
believed to be the progenitor of epidermoid and mucous cells.
- The epidermoid cells, together with intermediate and mucous cells
line cystic spaces or form solid masses or cords.
ADENOID CYSTIC CARCINOMA: (Cylindroma)
Adenoid cystic carcinoma is a slow-growing but aggressive
neoplasm with a remarkable capacity for recurrence, and considered
the second most common malignant tumor.
Clinical features:
- The salivary glands most commonly involved by this tumor are the
parotid, followed by the submandibular and the accessory glands in
the palate and tongue.
- It occurs most commonly during the fifth and sixth decades of life,
- Seen more commonly in females.
Clinical manifestations are early local pain, facial nerve paralysis in
the case of parotid tumors, fixation to deeper structures and local
invasion.
Some of the lesions, particularly the intraoral ones, exhibit surface
ulceration.
Histopathological features:

- Adenoid cystic carcinoma is composed of epithelial and

myoepithelial cells in variable morphologic configurations,
including tubular, cribriform and solid patterns.
- The most common seen is the cribriform pattern which shows
basaloid epithelial cell nests that form multiple cylindrical cysts
like patterns resembling a Swiss cheese pattern, which is the most
classic and best recognized pattern.
- These are filled with basophilic mucoid material.
 Perineural invasion is a common and the tumor can extend along
nerves for a considerable distance, in addition, the tumor may invade
bone extensively.

Cribriform pattern with mucopolysaccharide

filled spaces.