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    Barriers of Protein and Peptide Drug Delivery

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    Aashish chaudhari
    The document discusses the barriers to protein and peptide drug delivery. It identifies 4 main barriers: 1) Enzymatic barriers from pancreatic enzymes that degrade proteins and peptides in the intestines. 2) Intestinal epithelial barriers, including tight junctions between cells that limit absorption. 3) Capillary endothelial barriers where proteins must pass between or through cells to enter circulation. 4) The blood-brain barrier which tightly regulates what can enter the brain and prevents entry of most large molecules like proteins. Overcoming these barriers is challenging but important for developing protein and peptide drugs.

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    Barriers of Protein and Peptide Drug Delivery

    Uploaded by

    Aashish chaudhari
    142 views12 pages
    The document discusses the barriers to protein and peptide drug delivery. It identifies 4 main barriers: 1) Enzymatic barriers from pancreatic enzymes that degrade proteins and peptides in the intestines. 2) Intestinal epithelial barriers, including tight junctions between cells that limit absorption. 3) Capillary endothelial barriers where proteins must pass between or through cells to enter circulation. 4) The blood-brain barrier which tightly regulates what can enter the brain and prevents entry of most large molecules like proteins. Overcoming these barriers is challenging but important for developing protein and peptide drugs.

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    Aashish K. Chaudhari ( PPT )[1]

    Original Title

    Barriers Of Protein And Peptide Drug Delivery

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    The document discusses the barriers to protein and peptide drug delivery. It identifies 4 main barriers: 1) Enzymatic barriers from pancreatic enzymes that degrade proteins and peptides in the intestines. 2) Intestinal epithelial barriers, including tight junctions between cells that limit absorption. 3) Capillary endothelial barriers where proteins must pass between or through cells to enter circulation. 4) The blood-brain barrier which tightly regulates what can enter the brain and prevents entry of most large molecules like proteins. Overcoming these barriers is challenging but important for developing protein and peptide drugs.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    142 views12 pages

    Barriers of Protein and Peptide Drug Delivery

    Uploaded by

    Aashish chaudhari
    The document discusses the barriers to protein and peptide drug delivery. It identifies 4 main barriers: 1) Enzymatic barriers from pancreatic enzymes that degrade proteins and peptides in the intestines. 2) Intestinal epithelial barriers, including tight junctions between cells that limit absorption. 3) Capillary endothelial barriers where proteins must pass between or through cells to enter circulation. 4) The blood-brain barrier which tightly regulates what can enter the brain and prevents entry of most large molecules like proteins. Overcoming these barriers is challenging but important for developing protein and peptide drugs.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 12

    Barriers of protein and pEptide drug delivery

    SHREE SURESHDADA JAIN INSTITUTE OF PHARMACEUTICAL


    EDUCATION & RESEARCH JAMNER
    Roll no. 03

    Presented by - Guided by –
    Aashish Kishor Chaudhari Mr. Samir Shaikh Lecturer
    F. Y. M Pharm (Sem- 1st) & PG Teacher
    Dept. of Pharmaceutics Dept. of Pharmaceutics
    ~: content :~

    1. Define Protein and Peptide .


    2. Barriers to Protein and Peptide drug delivery .
     Enzymatic Barriers .
     Intestinal Epithelial Barriers .
     Capillary Endothelial Barriers .
     Blood Brain Barriers .
    -: Define - Protein and Peptide

     Protein and Peptide drug delivery system are the Novel drug
    Delivery System.
     Proteins and peptides are the most abundant components of
    biological cells.
     They exist functioning such as enzymes, hormones, structural
    element and immunoglobulin.
    ~: Barriers to protein drug delivery :~

    1. Enzymatic barriers :-

     Major enzymatic barrier to absorption of proteins is


    pancreaticenzymes: peptidase, lipases, nucleases & esterases.
     These are secreted in considerable quantity into the intestinal
    lumen and rapidly hydrolyses macromolecules and lipids.
     Enzymatic degradation brought about via 2 ways :-

    1. Hydrolytic cleavage of peptide bonds by Insulin degrading


    enzyme, ACE & Renin.
     Proteolysis is irreversible reaction and hence causes
    damage of peptides and protein drugs.

    2. Chemical modification of protein such as phosphorylation by


    kinases, oxidation by xanthine oxidase or glucose oxidase.
     It limits absorption of protein drugs from GIT.
    2. Intestinal Epithelial Barriers :-
     The intestinal epithelium is the single cell layer that form the
    luminal surface (lining) of both the small and large intestine
    (Colon) of the gastrointestinal tract composed of Simple
    columnar epithelial cells supported by lamina propria
    muscularis mucosa.

     Brush border is microvilli covered surface of cell found in


    small intestine, these plays imp.role in nutrient digestion and
    absorption.
     Tight junctions mediate the paracellular pathway of
    absorption in intact membranes and are rate limiting step in
    transepithelial transport.
    3. Capillary Endothelial Barriers :-

     To cross capillary endothelium the proteins must pass


    between cells or alternatively transverse the endothelial cells
    themselves.
     Solutes that transverse endothelial cell membrane may get
    metabolised by cytoplasmic enzymes.
     Thus the endothelial passes enzymatic barrier to solution
    package.
    4. Blood brain barriers :-

     Represents major obstacal to brain compartments.

     Collection of cells that press together to block many


    substances from entering the brain while allowing other to
    pass.

     Allow passage to lipid mediated transport of small but


    lipophilic molecules and gases.
     Large molecules like proteins donot pass the BBB early.
    ~: reference :~

     A TEXT BOOK OF DRUG DELIVAR SYSTEM


    PUBALISHED BY PEEVEEPUBALICATION AUTHORIZE
    BY PRAFULLN P. PATIL, BHUSHAN P. GAYAKWAD,
    Dr.MD. RAGEEB MD.USMAN AND Dr. SUROJJ SARODE .
     Saba Saeed 1, Mavra Irfan 1, Saima Naz 2, Momil Liaquat 2,
    Shafaq Jahan 2, Sana Hayat 2Routes and barriers associated
    with protein and peptide drug delivery system 2021 Aug.
     www.google.com

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