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IRRITABLE BOWEL

SYNDROME

DR. MUHAMMAD KALEEM


MBBS, FCPS (MEDICINE), FCPS(Gastroenterology)
ASSISTANT PROFESSOR OF MEDICINE
SRMCH, TDM
 Irritable bowel syndrome (IBS) is a common functional
bowel disorder in which abdominal pain is associated
with defecation or a change in bowel habit in the absence
of structural pathology.
 Approximately 10–15% of the general population are
affected but only 10% of these consult their doctors with
symptoms.

 IBS is the most common cause of GI referral, and causes


frequent absence from work and impaired quality of life
 Young women are affected 2–3 times more often than
men.

 There is wide overlap with non-ulcer dyspepsia, chronic


fatigue syndrome, dysmenorrhoea and urinary frequency.

 Between 5 and 10% of patients have a history of


physical or sexual abuse.
Most patients seen in general practice do not have
psychological problems but ~50% of patients referred to
hospital have significant

 Anxiety,
 Depression,

 Somatization,

 Panic attacks

 Neurosis.
 Acute psychological stress and overt psychiatric disease
alter visceral perception and GI motility.

 These factors, coupled with abnormal illness behaviour,


contribute to but do not cause IBS.
 A range of motility disorders from diarrhoea to
constipation is found but none is diagnostic.

 IBS is associated with altered 5-HT release, which is


increased in diarrhoea-predominant disease and reduced
when constipation occurs.
 Some patients develop IBS following an episode of
gastroenteritis, more commonly young women and those
with existing background psychological problems.

 Others may be intolerant of specific dietary components,


particularly lactose and wheat.
CLINICAL FEATURES AND
INVESTIGATIONS

 Recurrent colicky pain in the lower abdomen is relieved


by defecation.

 Abdominal bloating worsens throughout the day; the


cause is unknown
 Patients have an abnormal bowel habit.

 It is useful to classify these as having predominantly


constipation or predominantly diarrhoea.
 The constipated type tends to pass infrequent pellety
stools, usually with abdominal pain or proctalgia.

 Those with diarrhoea have frequent defecation but


produce low-volume stools and rarely have nocturnal
symptoms.

 Passage of mucus is common but rectal bleeding does


not occur.
 Patients do not lose weight and are constitutionally well.

 Examination does not reveal any abnormalities, although


bloating and tenderness to palpation are common.
Investigations are normal.

 FBC

 Faecal calprotectin

 Sigmoidoscopy are usually done routinely


 Colonoscopy should only be undertaken in older patients
and those with rectal bleeding to exclude colorectal
cancer and IBD.
MANAGEMENT

 Many patients are concerned that they have developed


cancer, and a cycle of anxiety leading to colonic
symptoms, which further heighten anxiety, can be broken
by explanation that symptoms are not due to organic
disease but are the result of altered bowel motility and
sensation.
 In patients who fail to respond to reassurance,
symptomatic treatment should be tried.

 Elimination diets are generally unhelpful but some may


benefit from exclusion of wheat, lactose, excess caffeine
or artificial sweeteners such as sorbitol.

 Probiotics can be effective in some.


 Patients with intractable symptoms sometimes benefit
from several months of therapy with low-dose
amitriptyline.

 Anxiety or affective disorders should be separately


treated.
PSYCHOLOGICAL INTERVENTIONS,
SUCH AS

 Cognitive behavioural therapy

 Relaxation

 Gut directed hypnotherapy, are reserved for the most


difficult cases.

Most patients have a relapsing and remitting course.


COGNITIVE BEHAVIOURAL THERAPY
Q.NO.01. Which of the following is NOT a common
symptom of IBS?

 A. Abdominal pain
 B. Bloating

 C. Constipation

 D. Weight gain

 Answer: D. Weight gain


 What is the most common subtype of IBS?

 A. IBS with constipation (IBS-C)


 B. IBS with diarrhea (IBS-D)

 C. Mixed IBS (IBS-M)

 D. Unsubtyped IBS (IBS-U)

 Answer: B. IBS with diarrhea (IBS-D)


 Which of the following medications is NOT typically
used in the treatment of IBS?

 A. Laxatives
 B. Antispasmodics

 C. Antibiotics

 D. Beta-blockers

 Answer: D. Beta-blockers
 What dietary approach is often recommended for
managing IBS symptoms?

 A. Gluten-free diet
 B. Low FODMAP diet

 C. Ketogenic diet

 D. Mediterranean diet

 Answer: B. Low FODMAP diet


 Which of the following statements about IBS is FALSE?

 A. IBS is a structural disease.


 B. Stress can exacerbate IBS symptoms.

 C. IBS is more common in women than in men. D. There


is no cure for IBS, but symptoms can often be managed.

 Answer: A. IBS is a structural disease.

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