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    Creatine Metabolism-1 Niveth

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    Priyanka Ravi

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    Creatine Metabolism-1 Niveth

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    Priyanka Ravi
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    3 views16 pages

    Creatine Metabolism-1 Niveth

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    Priyanka Ravi

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    of 16

    CREATINE

    METABOLISM
    NIVETHKUMAR.K
    ROLLNO.58
    LEARNING
    OBJECTIVES
     INTRODUCTION
     CREATINE BIOSYNTHESIS
     CREATINE METABOLISM
     RELATIONSHIP BETWEEN CREATINE
    AND CREATINE PHOSPHATE
     CREATINE DEGRADATION
    INTRODUCTION
     Creatine is an amino acid that does not found in protein
     Creatine is an nitrogenous organic acid
     It constitutes about 0.5% of total muscle mass
     It is synthesized from 3 amino acids
    -glycine
    -arginine
    -methionine
    WHAT’S CREATINE AND
    CREATININE
     Creatine and creatinine are not the same substance.
     Creatine is found the muscles.
     Creatinine is a break-down product(a waste product ) of
    creatine phosphate and creatine in muscles, and is usually
    product of fairly constant rate by the body depending on
    the muscle mass.
    CREATINE BIOSYNTHESIS
     It is synthesized from 3 amino acid
    - glycine
    -arginine
    -methioine
     Site of biosynthesis
    - Step 1 = Kidney
    - Step 2 = Liver
    DISTRIBUTION OF BODY
    CREATINE
    From liver transported to other tissue
    98% are present in skeletal and heart muscles.
    In muscles gets converted high energy sources
    creatine phosphate
    METABOLISM OF CREATINE
     STEP 1
     The amidino group of arginine is transferred to glycine to form
    guanido acetic acid [guanidine acetate]
     Catalyzed by amidotransferase
     It is seen in mitochondria of kidney and pancreas not in liver
     STEP 2
     Guanido acetic acid is methylated by S-adenosyl methionine by
    methytransferase to form creatine.
     This methylation reaction takes place in liver.
     STEP 3
     Creatine is phosphorylated to creatine phosphate.
     The enzyme creatine kinase is present in muscle brain and liver. The
    reaction needs hydrolysis of ATP
     .The stored creatine phosphate in the muscle serves as an immediate
    store of energy in the muscle. During muscle contraction the energy is
    first derived from ATP hydrolysis.
     Thereafter the ATP is regenerated by the hydrolysis of creatine
    phosphate.
     This is called the Lohmann’s reaction.

     STEP 4
     The creatine phosphate may be converted to its anhydride, creatinine.
     It is a nonenzymatic spontaneous reaction.
    CREATINE METABOLISM
    RELATIONSHIP BETWEEN CREATINE
    AND CREATINE PHOSPHATE
    Creatine and creatine phosphate exist in a
    reversible equilibrium in skeletal muscle
    In skeletal muscle approximately one fourth of
    creatine exist as free creatine and three fourth exist
    as creatine phosphate
    CREATINE PHOSPHATE
    Creatine phosphate high energy phosphate compound.
    Act as the storage form of energy in muscle.
    Provides a small but ready source of energy during few minutes of intense
    muscular contraction.
    The amount creatine phosphate in the body is proportional to the muscle mass.
    CREATINE DEGRADATION
    Creatine and creatine phosphate spontaneously form creatinine as the end product
    Creatinine is excreted in the urine
    Serum creatinine is a sensitive indicator of kidney disease( Kidney function test)
    Serum creatinine increase with the impairment of the kidney function
    EXCRETION OF CREATINE
     Normal level of creatinine in human body
    Male – 0.7 to 1.3 mg/dl
    Female – 0.6 to 1.1 mg/dl
    Infants - less than 0.5 mg/dl

     Creatine deficiency disorder ( CDDs )


     Inborn errors that effects the transportation and metabolism of creatine
     Guanidinoacetate merthyltransferase(GAMT) deficiency
     L-arginine;glycine aminotransferase(AGAT) deficiency
     Creatine transporter (CRTR) deficiency
    It is typically present in all older children and adults
    SUMMARY
     Creatine is an amino acid and it is a nitrogenous
    organic acid
     It is synthesised from 3 amino acids
     It is highly found in muscle
     It are biosynthesis in liver and kidney
     It are excreted in the form of creatinine
     THANK YOU

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