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Tuberculosis
• Tuberculosis (TB) is an infectious disease that most often affects the
lungs and is caused by a certain type of bacteria. It is spread through the air when infected people cough, sneeze or expectorate. • SymptomsPeople with latent TB infection do not feel sick and are not contagious. Only a small proportion of infected people develop TB and show symptoms. Infants and children are at increased risk.People who:suffer from diabetes (high blood sugar);have a weakened immune system (for example, people with HIV infection or AIDS);suffer from malnutrition;use tobacco. PreventionTo prevent TB infection and spread, you must do the following:If you experience symptoms such as a persistent cough, fever and unexplained weight loss, seek medical help as treating TB early can help stop the disease from spreading and improve your chances of recovery.Get tested for TB infection if you are at increased risk, for example if you have HIV infection or have contact with people with TB at home or at work.If you are prescribed treatment to prevent TB, complete the entire course.If you have TB, practice good cough hygiene, including avoiding contact with other people and wearing a mask, covering your mouth and nose when coughing or sneezing, and properly disposing of sputum and used tissues.Specific measures such as the use of respirators and ventilation are essential to control the spread of infection in health care and other settings. • DiagnosticsWHO recommends rapid molecular diagnostic tests as the initial diagnostic test for all people with signs and symptoms of TB.WHO recommends Xpert MTB/RIF Ultra and Truenat as diagnostic rapid tests. These tests have high diagnostic accuracy and will lead to significant improvements in the early detection of TB and drug-resistant TB.A tuberculin skin test (TST) or an interferon gamma release assay (IGRA) may be used to identify people with infection.Diagnosing multidrug-resistant TB and other resistant forms of TB (see section on multidrug-resistant TB below), as well as HIV-associated TB, can be difficult and expensive.Tuberculosis is especially difficult to diagnose in children. • TreatmentTuberculosis should be treated with antibiotics. Treatment is recommended for both TB infection and TB disease.The most commonly used antibiotics are:isoniazid,rifampicin,pyrazinamide,ethambutol,streptomycin.For effective treatment, these drugs must be taken daily for 4–6 months. It is dangerous to stop taking medications prematurely or without consulting a doctor. This may allow the TB pathogen that persists in the body to become drug resistant.Tuberculosis that does not respond to standard drugs is called drug-resistant TB and requires the use of more toxic drugs.