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Cotrimoxazole
Co-trimoxazole is a combination of sulfamethoxazole,
a sulfa drug and Trimethoprim in a ratio 5: 1 Preparation available: Tablet, suspension Tablet ( sulfamethoxazole 400mg + Trimethoprim 80mg)=480 Tablet (sulfamethoxazole 800mg + Trimethoprim 160mg )=960
Suspension: (40mg+ 200 mg ) per 5 ml MOA Folate antagonist They inhibit the folic acid synthesis in bacteria.
Folic acid is required for synthesis of DNA, RNA,
Protein, Aminoacid.
Human can absorb folic acid from diet but bacteria
reductase and prevent the reduction of dihydrofolic acid to tetrahydrofolic acid Cotrimoxazole MOA What are the benefit of combination? There is synergistic action.
When used individually they are bacteriostatic but