A CHLORPROMAZINE PPT Final (1) EDITED BY AVINASH

By-
Atul sharma (roll no. 17)

CHLORPROMAZINE Avinash pundhir (roll no. 18)
Ayush (roll no. 19)
Ayush singh( roll no. 20)
Objective: Exploring the
evolution and impact of
chlorpromazine in psychiatry
Overview of chlorpromazine
Historical timeline
Impact on psychiatry
Side effects and concerns
Future directions
Conclusion
Overview of chlorpromazine
Introduction
• First antipsychotic medication introduced in early
1950s.
Revolutionizing Mental Health Treatment

• Transformed treatment approaches for schizophrenia
and bipolar disorder.
Shift from invasive to Pharmacological
• Marked a significant change from invasive treatments to
medical based solutions.
Impact on severe depression

• Provided new options for managing severe depression
effectively.
History of
chlorproma
zine
developme
nt
Henrie Laborit discovered

the anti –histaminic and
anti-shock properties of
Phenothiazines
Henrie Laborit
History of
chlorpromazi
ne
development Synthesis of chlorpromazine
In France, Paul Charpentier and
Simone Courvoisier first synthesized
chlorpromazine, laying the groundwork
for revolution in psychiatric medicine.
Paul Charpentier
Chlorpromazine was commercialized in France in 1952 with
commercial name of LARGACTIL
(large= broad , acti – activity) it reflects its wide spectrum
of pharamacological activities
Gangliolytic
Adrenolytic
Antifibrillatory
Antiedema
Antipyretic
Anti-shock
Anti-convulsant
Anti-emetic
Introduction as
antipsychotic
Chlorpromazine was introduced as the first antipsychotic
medication, showing superior efficacy compared to
traditional treatments like morphine and scopolamine.
Market
launch in Thorazine, the commercial name for
the U.S. chlorpromazine was marketed in the
U.S. supported by the first randomized
controlled trial that established its
efficacy in treating psychosis.
The Psychopharmacological
Era
• Improved patient outcomes
• Replacement of invasive treatments
• Acknowledgement by WHO
Clinical efficacy of
Chlorpromazine
Significant
Enhanced Numerous
symptom
quality of life clinical trials
improvement
• Chlorpromazine • Patients often • The effectiveness of
effectively reduces report a marked Chlorpromazine is
psychotic symptoms improvement in backed by a
in schizophrenia and their overall quality multitude of clinical
bipolar patients. of life post trials conducted
treatment. since its
introduction.
Common side effects
Movement disorders
Spasms
Tardive dyskinesia
Risk-Benefit balance
FUTURE DIRECTIONS
Recent research on chlorpromazine (CPZ), traditionally an antipsychotic, has explored its
potential beyond psychiatric applications. One significant area is its role as an adjunct in cancer
therapy, specifically for glioblastoma. A 2023 study investigated the effects of combining CPZ
with standard treatment for glioblastoma patients who had an unmethylated MGMT gene
promoter. The trial demonstrated promising results in terms of progression-free survival,
suggesting that CPZ may enhance the efficacy of existing chemotherapy regimens, despite some
dose-dependent side effects like sedation and liver toxicity
SOME INTRESTING FACTS TO
KNOW :
Accidental Discovery of Antipsychotic Properties: Chlorpromazine was not initially designed to
be an antipsychotic. It was developed as an anesthetic adjuvant to reduce shock during surgery,
and its antipsychotic effects were discovered by accident when doctors noticed its calming
effects on patients
The "Chemical Straitjacket": Early on, chlorpromazine was nicknamed the "chemical straitjacket"
because of its ability to calm agitated psychiatric patients without the need for physical restraint.
This nickname reflected its role in transforming patient management in psychiatric institutions.
Pioneering Use in Space Medicine: Chlorpromazine was studied by NASA in the early days of
space exploration for its potential to help astronauts deal with nausea and vomiting caused by
motion sickness and zero gravity. However, its sedative properties made it less ideal for this
purpose.
Use in Animal Medicine: Chlorpromazine is sometimes used in
veterinary medicine, particularly for sedating large animals like horses
and dogs. It helps in managing anxiety and controlling aggressive
behavior in animals.
Combination with Electroconvulsive Therapy (ECT): Chlorpromazine has

sometimes been used in conjunction with ECT in the treatment of severe
mental illnesses, particularly treatment-resistant schizophrenia. This
combination can enhance the effects of ECT while reducing the number
of required treatments.
Combination with Electroconvulsive Therapy (ECT): Chlorpromazine has

sometimes been used in conjunction with ECT in the treatment of severe
mental illnesses, particularly treatment-resistant schizophrenia. This
combination can enhance the effects of ECT while reducing the number
of required treatments.
REFERENCE
www.pubmed.ncbi.nlm.nih.gov
www.pmc.ncbi.nlm.nih.gov
www.researchgate.net

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By-

Atul sharma (roll no. 17)

Side effects and concerns

Revolutionizing Mental Health Treatment

Impact on severe depression

Henrie Laborit discovered

• Replacement of invasive treatments

Combination with Electroconvulsive Therapy (ECT): Chlorpromazine has

Combination with Electroconvulsive Therapy (ECT): Chlorpromazine has

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