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    Tinospora cordifolia (Giloy): A Review of the Various Pharmacological

    Pathways of a Highly Potential Medicinal Ayurveda Plant

    Presented By
    AMARTYA KUMAR BHARDWAJ
    B PHARM (4TH YEAR 7TH SEMESTER)

    SHREE DEV BHOOMI INSTITUTE OF EDUCATION SCIENCE & TECHNOLOGY, VILL. -


    MAZHON, P.O. POUNDHA, DEHRADUN

    UNDER THE GUIDANCE OF


    Mrs.Vandana Sahani
    (ASSOCIATE PROFESSOR)
    CONTENT

    1 INTRODUCTION
    2 SCIENTIFIC CLASSIFICATION
    3 COMMON AND VERNACULAR NAMES
    4 BOTANICAL DESCRIPTION
    5 CONSTITUENTS
    6 DOSAGE,
    7 PROPERTIES,
    8. LITERATURE REVIEW
    9 AIM AND OBJECTIVE,
    10 RATIONALE OF STUDY
    11 CONCLUSION,
    12 REFERENCE
    INTRODUCTION

     Natural products with medicinal values are


    gradually gaining importance in clinical
    research due to their well-known property of
    no side effects as compared to
    drugs.Tinospora cordifolia is known as
    'amrita' in sanskrit, and is regarded high for
    its medicinal value.
    INTRODUCTION
    SCIENTIFIC CLASSIFICATION

     Kingdom- Plantae

     Unranked- Angiosperms
     Unranked- Eudicots

     Order- Ranunculates

     Family- Menispermaceae

     Genus- TinosporaSpecies- Tinospora cordifolia


    COMMON AND VERNACULAR NAMES

     Tinospora
    cordifolia is commonly called heart-leaved
    moonseed, guduchi, and giloy.
     Sanskrit- amrita, guduchi
     Hindi- giloy, guruc, gurcha
     Punjabi- glow
     Telugu- tippa teega
     Tamil- shindiakodi
    BOTANICAL DESCRIPTION

     Common plant of deciduous and dry forests.


    Large, deciduous, extensively spreading climbing
    shrub.
     Leaves: simple, alternate, exstipulate, long
    petiole upto 10-15cm long, roundish, pulvinate,
    lamina broadly ovate, 10-20cm long and 8-15cm
    broad.
     Sepals 6, polysepalous, petals 6, polypetalous.
    BOTANICAL DESCRIPTION

     Flowers: unisexual, small on separate plants, appearing


    when plant is leafless, greenish yellow on axillary and
    terminal racemes.

     Fruit:
    orange-red in colour, fleshy, ovoid, drupelets,
    develop during winter.
    CONSTITUENTS

     BERBERINE (ALKALOID)
     GILOIN (ALKALOID)
     VOLATILE OIL
     STARCH
    DOSAGE

     POWDER - 2.5 TO 5 GM
     DECOCTION - 40 ML
     JUICE-20 ML
     GILOY SATVA-500 TO 1000 MG
    PROPERTIES


    RAS - TIKAT [BITTER]
    KASHAY [ASTRINGENT]
     GUN – GURU SNIGDH
     VEERYA – SHEET
     VIPAK - MADHUR
    LITERATURE REVIEW

     Gupta Abhishek (2024) et.al : Tinospora cordifolia, commonly known as Giloy or Guduchi, is a widely
    used medicinal plant in traditional medicine systems, particularly in India and other Asian countries. This plant has
    long been revered for its therapeutic properties, with its use spanning the treatment of a wide range of diseases such
    as metabolic disorders, immune-related issues, diabetes, heart disease, cancer, and infections. Over the years,
    scientific investigations have revealed various bioactive phytochemical compounds in T. cordifolia, primarily
    isolated from its stem, roots, and whole plant. These compounds have shown potential in supporting diverse
    pharmacological activities, contributing to the plant’s growing recognition in the field of modern medicine.
     Mahajan Shurti (2024) et.al : Tinospora cordifolia (Giloy), a member of the Menispermaceae family, is
    widely recognized for its diverse therapeutic applications due to the presence of a broad spectrum of secondary metabolites. To
    understand the genetic basis of its medicinal properties, a comprehensive genomic study was carried out using state-of-the-art
    sequencing technologies, including 10× Genomics linked read and Nanopore long-read technologies. The genome sequencing
    of T. cordifolia resulted in a draft genome assembly of 1.01 Gbp (gigabase pairs). Genome size estimation revealed a slightly
    larger genome of 1.13 Gbp. This makes T. cordifolia the first plant from the Menispermaceae family to have its genome
    sequenced. The sequencing provided valuable insights into the genetic structure of the plant, which can be directly correlated
    with its medicinal properties.
    LITERATURE REVIEW

     Kumar, M. Vijaya (2024) et.al : Tinospora cordifolia (Tc), also known as Giloy, is a herbaceous
    vine that has been used for centuries in traditional medicine systems, particularly in India, for its broad therapeutic effects.
    Among its many purported benefits, T. cordifolia is most notably regarded for its potential anti-cancer properties. This
    systematic study reviews the existing scientific literature to evaluate the medicinal potential of T. cordifolia in combating
    various forms of cancer. Tinospora cordifolia (Giloy) holds significant promise as a potential supplementary treatment for
    cancer. Its demonstrated anti-proliferative, apoptotic, and anti-metastatic effects, coupled with its ability to influence key
    cancer-related pathways, suggest it could play a valuable role in integrated cancer therapy. However, the limitations in the
    current body of research, particularly the lack of robust clinical trials, underscore the need for further investigations to fully
    understand its therapeutic potential.

     Ahsan Rabiya ( 2023) et.al : Tinospora cordifolia is a versatile herb with a wide range of
    pharmacological effects, making it an important candidate for drug development in traditional and modern medicine. While its
    therapeutic potential is promising, more clinical and pre-clinical studies are needed to fully understand its efficacy and to
    establish it as a reliable treatment for COVID-19, endocrine disorders, and neurological conditions. The growing interest in
    this plant highlights the need for scientific validation and large-scale research to harness its full potential in healthcare .
    AIM AND OBJECTIVE

    Aim: Tinospora cordifolia (Giloy):A Review of the Various Pharmacological Pathways of a Highly Potential
    Medicinal Ayurveda Plant
    Objectives
    To find the Chemical Constituents of Giloy
     To find the pharmacological action of Giloy
    To find all active ingredients present in Giloy
    RATIONALE OF STUDY

    Traditional Importance : Widely used in Ayurveda as a rejuvenating herb for treating fever, infections, diabetes,
    and inflammation
    Rich in Bioactive Compounds : Contains alkaloids, flavonoids, and glycosides with therapeutic potential.

    Immune Booster : Known for its immunomodulatory effects, especially relevant in enhancing natural immunity.

    Anti-inflammatory and Antioxidant : Helps manage chronic conditions like arthritis and cardiovascular
    diseases.
    Antipyretic
    and Antimicrobial : Effective in treating fevers and infections .


    Chronic Disease Management: Aids in diabetes, liver health, and neuroprotection .


    Global Demand for Herbal Medicine : Supports evidence-based integration of natural
    remedies into healthcare .


    Safety and Standardization : Requires scientific validation for safe usage and dosage .
    CONCLUSION


    T. cordifolia's chemical diversity has been reviewed here. Antioxidant,
    antibacterial, anti-HIV, analgesic, anti-fungal, antiproliferative, and anti-epileptic
    are a few of the many possible effects. Its curative qualities have been well
    recognized. Potential future treatments for a variety of clinical disorders may
    include isolating pure lead compounds from the plant portion or from endophytic
    fungi separated from various areas of the plant. As a result, this evaluation serves
    both a scientific and clinical function in the quest for new therapeutics.
    REFERENCE

    1. Tran, N., Pham, B., & Le, L. (2020). Bioactive compounds in anti-diabetic plants: From
    herbal medicine to modern drug discovery. Biology, 9(9), 252.
    2. Alhazmi, H. A., Najmi, A., Javed, S. A., Sultana, S., Al Bratty, M., Makeen, H. A., ... &
    Khalid, A. (2021). Medicinal plants and isolated molecules demonstrating
    immunomodulation activity as potential alternative therapies for viral diseases including
    COVID-19. Frontiers in immunology, 12, 637553.
    3. Singh, N., & Yadav, S. S. (2024). Anti-dengue therapeutic potential of Tinospora cordifolia
    and its bioactives. Journal of Ethnopharmacology, 118242.
    REFERENCE

    4. Nayak, D., Nahar, K., Bhalerao, R., Kaur, L., Parveen, T., Bhalla, R., ... & Khurana, A. (2022). Effectiveness of
    Arsenicum album 30C in prevention of COVID-19 in individuals residing in containment zones of Delhi—A prospective,
    community-based, parallel cohort study. Homeopathy, 111(04), 261-270.
    5. Saini, R., & Dhiman, N. K. (2022). Natural anti-inflammatory and anti-allergy agents: herbs and botanical ingredients.
    Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistryrrent Medicinal Chemistry-Anti-Inflammatory and Anti-
    Allergy Agents), 21(2), 90-114.
    6. Patil, S., Ashi, H., Hosmani, J., Almalki, A. Y., Alhazmi, Y. A., Mushtaq, S., ... & Vyas,

    N. (2021). Tinospora cordifolia (Thunb.) Miers (Giloy) inhibits oral cancer cells in a dose- dependent manner by inducing
    apoptosis and attenuating epithelial-mesenchymal transition. Saudi journal of biological sciences, 28(8), 4553-4559.
    THANK YOU

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