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    The Lipid Droplet

    Uploaded by

    Mariah Uddin

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    The Lipid Droplet

    Uploaded by

    Mariah Uddin
    3 views4 pages

    Copyright

    © © All Rights Reserved

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    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    3 views4 pages

    The Lipid Droplet

    Uploaded by

    Mariah Uddin

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
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    The Lipid droplet is unusual because it is bound by a membrane monolayer

    Triacylglycerol (Fats)

    glycerol 3xFA-CoA Triacylglycerol + 3xCoA


    Acyl-transferases

    Cholesterol ester

    Neutral/lipophilic

    lcFA sterol rings

    FAs are stored primarily as triglycerides (triacylglycerols)


    Can be made in the smooth ER (Prof Philpott) of all cells but professional fat cells (adipocytes)
    specialise in storing lipid droplets

    Efficient: 1g triglyceride = 6x energy store of 1g glycogen, and occupies less volume


    Lipids (fats) are hydrolysed by lipases to release lcFAs for energy production by the Mx

    Only organelle bound by a membrane monolayer Glycerol + 3xFA

    H2O +ATP
    Lipase
    1 x Glycerol + 3 x FA-CoA FA-CoA
    TAG
    Acyl-transferase x 3
    mitochondrion
    TAG
    smooth See task 6 for refresher on
    Krebs cycle and oxidative
    phosphorylation

    Week 3 for Prof Philpott’s


    lecture on organelles

    Week 8 for Dr Hannen’s


    lecture on cellular energy
    The hydrophobicity of the acyl chains of the membrane monolayer surrounding a lipid droplet
    is satisfied by the hydrophobicity of the contents…….

    LIPID Droplet
    Learning outcomes
    • Understand where lipids and cholesterol esters are stored in the cell
    • Understand that lipid droplets are an important energy store and source
    of intermediates for anabolism
    • Know where and how lipid droplets are made and why they are the only
    organelle bound by a membrane monolayer

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