BC-6000/BC-6200

Auto Hematology Analyzer

High Performance for ALL

CONTENT

Principle
Product introduction
 SF Cube technology

Forward laser scatter

Cell size
S
Side laser scatter Cellular complexity

F Fluorescence DNA/RNA information

Cube 3D cell analysis

 DIFF Channel

FL
SS

FS

M-6 LD Lyse, M-6 FD Dye

Penetration power

Penetrability
DNA/RNA information

Bigger nucleus More DNR/RNA Higher fluorescence

DIFF Channel

Penetrability
RBC LYM MON NEU EOS

LD lyse

RBC LYM MON NEU EOS

Dying
FD Dye

RBC LYM MON NEU EOS

DIFF Channel
Fluorescence
LD lyse FD Dye Signal Intensity

WBC WBC WBC

Penetrability

Dying
BLAST/ALY BLAST BLAST
ALY ALY

IMG IMG IMG

DIFF Channel parameters

HFC%* IMG%

Left shift
MON%

(NEU+
BAS)%
LYM%

NRBC EOS%

PLT Clump InR‰* Parameters

ABC
* Research Use Only Parameter Flags
ABC
DIFF Channel parameters

Particles in Infected RBC area

InR#*
Particles in WBC area

WBC-D

InR#*
InR‰*
RBC

Note: the yellow scatters are just for highlight.

* Research Use Only Parameter

DIFF Channel parameters

LYM# LYM% WBC

MON# MON% WBC

NEU# NEU% WBC WNB channel

EOS# EOS% WBC

NEU% (NEU+B BAS%

AS)%
DIFF Channel

Reportable Parameters:
LYM%, LYM#, MON%, MON#, EOS%, EOS#, NEU%, NEU#, IMG%, IMG#

Research Parameters:
WBC-D*, HFC%*, HFC#*, InR#*, InR‰*, IME#*, IME%*,NLR*,PLR*, H-NR%*, L-NR%*,
TNC-D*,

* Research Use Only Parameter

WNB channel

SS FL

FS

M-6 LN Lyse, M-6 FN Dye

 WNB Channel

Penetrability
RBC NRBC WBC
BAS
LN lyse

RBC NRBC BAS WBC

Dying
FN Dye

RBC NRBC BAS WBC

Fluorescence
Signal Intensity
WNB parameters
Automatically corrects total WBC count and 5-part diff results.
Including NRBC with every CBC

NRBC% Baso% WBC-N*

* Research Use Only Parameter
WNB Channel NRBC parameters

Particles in (1) area

NRBC%
Particles in (2) area

100%
(1)
(2)
NRBC# WBC NRBC%
WNB Channel Baso parameters

Particles in (1) area

Baso%
Particles in (2) area

100%
(1)

(2)
Baso# WBC Baso%
WNB Channel parameters

Reportable Parameters:
NRBC%, NRBC#, BASO%, BASO#, WBC

Research Parameters:
WBC-N*, TNC-N*

* Research Use Only Parameter

RET Channel

FL
SS

FS

M-6 DR diluent , M-6 FR Dye

 About Sphere

Without sphering

Cell passed through laser

by position 1 Laser

Different
scatters

Cell passed through laser

Laser
by position 2
 About Sphere

With sphering

Cell passing through laser

by position 1 Laser

Same
scatters

Cell passing through laser

by position 2
Laser
RET Channel

RBC RET PLT

Sphering
DR Diluent

RBC RET PLT

Dying
FR Dye

RBC RET PLT

Fluorescence
Signal Intensity
 RET Channel

IRF MFR HFR

IRF: Immature Reticulocyte Fraction

The number of PLT in IPF region

IPF
The total number of PLT

RBC-O* 100%

RHE (Reticulocyte Hemoglobin Expression) is

calculated according to the
PLT-O* volume of reticulocyte.
MRV* (Mean Reticulocyte Volume) is
calculated according to the
volume of reticulocyte.

LFR MFR HFR WBC-R* RHE MRV * FRC * RPI *

* Research Use Only Parameter
RET Channel

RET

PLT-O RET-EXT

RET PLT-O* WBC-R*

measurement measurement measurement
* Research Use Only Parameter
RET parameters

RHE & MRV

RET

Retic
The volume of Retic

RHE (Reticulocyte Hemoglobin Expression) is calculated according to the volume of reticulocyte.

MRV* (Mean Reticulocyte Volume) is calculated according to the volume of reticulocyte.
* Research Use Only Parameter
RET parameters

PLT-O* parameter
Optical + Fluorescence measurement

FRC

Large PLT

Normal PLT

* Research Use Only Parameter

RET parameters

PLT-O*
Optical + Fluorescence
IPF
Immature Platelet Fraction
The number of PLT in IPF region
IPF
The total number of PLT
* Research Use Only Parameter 100%
RET Channel

Reportable Parameters:
RET%, RET#, IRF, LFR, MFR, HFR, IPF, RHE

Research Parameters:
RBC-O*, PLT-O*, WBC-O*, MRV*, IPF#*, FRC#*, FRC%*, RPI*, H-IPF*,

* Research Use Only Parameter

RBC/PLT Channel

U=R*I
When cell passing through the aperture by
vacuum, it will induce the change on
Aperture resistance.
+ - With a constant current, the voltage change
signal will be recorded and accords with the
Electrode Vacuum volume of the cell.
RBC/PLT Channel

RBC * MCV
HCT =
10

HGB
MCH =
RBC
MCV RDW-CV RDW-SD
HGB
MCHC = * 100
HCT

PLT * MPV
PCT =
10000
MPV PDW
RBC/PLT Channel
Microcyte & Macrocyte
60 fL 120 fL
RBC histogram

Microcyte Macrocyte

The number of RBC larger than 120fL

Macro%* 100%
The total number of RBC
The number of RBC smaller than 60fL
Micro%* 100%
The total number of RBC

* Research Use Only Parameter

HGB Channel

LH
525nm
Analysis Principles – RBC/PLT/HGB

Reportable Parameters:
RBC, MCV, HCT, RDW-SD, RDW-CV, HGB, MCH, MCHC
PLT, MPV, PCT, PDW, P-LCC, P-LCR,

Research Parameters:
PLT-I*, PDW-SD*, Micro#*, Micro%*, Macro#*, Macro%*

* Research Use Only Parameter

Analysis Principles – Body fluid

SF Cube
Items Parameter Meaning
WBC series (6 WBC-BF White Blood Cell count-body fluid
parameters) TC-BF# Total nucleated cell counts-body fluid
MN# Mononuclear cell number
MN% Mononuclear cell percentage
PMN# Polymorphonuclear cell number
PMN% Polymorphonuclear cell percentage

DC method
Aperture
+ - Items
RBC series (1
Parameter
RBC-BF
Meaning
Red Blood Cell count-body fluid
parameter)
Electrode Vacuum
 Analysis Principles – Body fluid

7 research parameters RBC-BF & RBC-BF*

Items Parameter Meaning
WBC series (6 parameters) Eos-BF# Eosinophils number- body fluid
Eos-BF% Eosinophils percentage- body fluid
Neu-BF# Neutrophil number- body fluid
Neu-BF% Neutrophil percentage- body fluid New
HF-BF# High fluorescent cell number- body fluid
HF-BF% High fluorescent cell percentage- body fluid
RBC series (1 parameter) RBC-BF Red Blood Cell count-body fluid

Formula
HF-BF* (high fluorescent cells)
WBC=MN+PMN
MN (mononuclear cells)
TC-BF=WBC+HF-BF

HF-BF may contain: histiocyte, PMN (polymorphonuclear cells)

epithelial cell, spleen cell,
Eos-BF* (Eosinophils)
exfoliated cell, etc.
Neu-BF* (Neutrophils)
* Research parameter
Analysis Principles
Counting channels Reagents Technology Graphics Parameters

LYM
DIFF M-6 LD Lyse DIFF Scattgram MON
1 channel
M-6 FD Dye
SF Cube (3D*1+2D*1)
NEU
EOS
WBC-D*

WNB M-6 LN Lyse NRBC Scattgram NRBC

2 channel M-6 FN Dye
SF Cube (3D*1+2D*1)
Baso
WBC-N*

RET M-6 DR Diluent RET Scattgram

RET
3 channel
M-6 FR Dye SF Cube (3D*1+2D*3)
PLT-O*
WBC-R*

RBC DC RBC histogram RBC

4 channel DS Diluent PLT
Impendence PLT histogram

HGB M-6 LH Lyse Colorimetry HGB

5 channel
Analysis summary

2 histograms

5 scattergrams
3 three-dimensional
scattergrams
CONTENT

Principle
Product introduction

Competitors
A introduction to BC-6000 series
Product model

BC-6000

Parameter BC-6000 BC-6200

WNB √ √
RBC/PLT √ √
HGB √ √
BC-6200
DIFF √ √
RET - √
Body-F √ √
110 tests/hour (CBC+DIFF)
50 sample tubes capacity
Total Routine Parameters
RBC RET# NRBC# PLT WBC
MCV RET% NRBC% MPV LYM#
HCT LFR PCT LYM%
RDW-SD MFR PDW MON#
RDW-CV HFR P-LCC MON%
HGB IRF P-LCR NEU#
MCH RHE IPF NEU%
MCHC EOS#
EOS%
BAS#
BAS%
IMG#
IMG%

BC-6200
8 7 2 7 13
37 reportable parameters 7 body fluid reportable parameters
29 research parameters 11 body fluid research parameters
Total Routine Parameters

RBC NRBC# PLT WBC

MCV NRBC% MPV LYM#
HCT PCT LYM%
RDW-SD PDW MON#
RDW-CV P-LCC MON%
HGB P-LCR NEU#
MCH NEU%
MCHC EOS#
EOS%
BAS#
BAS%
IMG#
IMG%

BC-6000
8 2 6 13
29 reportable parameters
20
7 body fluid reportable parameters
research parameters 11 body fluid research parameters
Research Parameters

HFC# IME% RPI

InR#
HFC% IME# H-IPF
InR‰
PLT-I H-NR% IPF#
Micro#
WBC-D L-NR% MRV
Micro%
TNC-D NLR FRC#
Macro#
PLR FRC%
Macro%
WBC-N WBC-O
PDW-SD
TNC-N RBC-O
PLT-O

29 research parameters for BC-6200

20 research parameters for BC-6000
 Throughput and counting mode

Whole blood Capillary blood Predilute body fluid

Autoloader:110T/H CT:40 T/H
CT:110T/H

CBC CD CDR CR RET

RET channel only for BC-6200

Configuration

01 Close Tube
Standard 04
Configuration

Normal Rack
02 Standard Standard
Configuration Configuration

05
03 Built in barcode
scanner

Standard
Configuration

Standard PC
Configuration Printer
Local purchase
Installation requirement

Vo l t a ge Working temperature
110V/115V 15~32 ℃
220V/230V

Atmospheric Altitude
70kPa-106kPa 0-3000m
Reagent

Lyse
1L/4L M-6 LN M-6 FN DS
2years
Lyse Dye Diluent

Dye
12/48mL M-6 LD M-6 FD M-6 LH
1year
Lyse Dye Lyse

Diluent
20L/10L
M-6 DR M-6 FR Probe
2years Diluent Dye cleanser

Open life: 60days, FR dye /DR Diluent:90days Storage:2-30℃

 Value

Value Operation Cost

Including NRBC with every CBC
NRBC not normally seen in the peripheral blood beyond the neonatal period.
represent the stages of red blood cells before they matures.

NRBC

Automatic correction Diagnosis for Monitoring of Reduce the ratio of

WBC counting, make hemolytic anemia hematopoietic
sure new born counting positive samples
diseases
correctly
 Excellent ability to distinguish immature cells

Promyelocyte

Myelocyte

Metamyelocyte

Band

Neutrophil

The immature granulocytes(IMG), normally absent from peripheral blood. are increased in
conditions such as bacterial infections, acute inflammatory disorders and so on. It is significant for
clinical diagnosis. Meanwhile, Reportable this parameter to significantly reduce the number of
smears.

© 2012 Mindray
51 Confidential
Extend count time

Low WBC

LOW PLT

Regular measurement Extent count time

For leucopenic samples( WBC<1.5*/L)or capillary blood samples,

BC-6200/6000 can automatically extent count times to 3folds. The WBC Counts more accuracy
and reliability.
BC-6200 can automatically extent counts times to 5folds with low value PLT samples. The PLT
results can be detected with high accuracy.

© 2012 Mindray
52 Confidential
 3 WBC counting channels

Normal sample NRBC sample

6 6
5 5

WBC value
WBC value

4 4
3 3
2 Report WBC 2 Report
1 1 Flag corrected
0 0 WBC
WBC-D WBC-N WBC-R WBC-D WBC-R WBC-N
Counting channel Counting channel
Fragile WBC sample Lyse-resistant RBC sample
6 6
5 5
WBC value

WBC value
4 4
3 3
Report
2 corrected 2
1 WBC 1 Flag Report WBC
Flag
0 0
WBC-D WBC-N WBC-R WBC-D WBC-N WBC-R
Counting channel Counting channel
 Infected RBC
DIFF Angle 1 DIFF Angle 2

Flagging & measure “Infected RBC”

Plasmodium Correlated with Malaria

Lipid sample

WBC: fluorescence

Lipid particle: no fluorescence

 PLT clump

BC-6000series show more powerful differential capability to reveal abnormal Cells for customer.
New FR dye

Stronger fluorescent signal

By utilizing the new fluorescent dye, the Reticulocytes and Platelets are more specific
stained with stronger fluorescent signal, that brings more accurate Reticulocyte and
Platelet results.

© 2012 Mindray
57 Confidential
 Superior performance of PLT-O

PLT-O result avoids the interference from

Microcytosis and fragmented RBCs,
large platelets and/or platelet clumps.

PLT-O* parameter
PLT-O*
Optical + Fluorescence measurement
* Research Use Only Parameter
 RHE(Reticulocyte Hemoglobin Expression)
RET
The volume
of Retic Retic

The reticulocyte hemoglobin content (RHE) provides an indirect measure of the functional iron
available for new red blood cell production over the previous 3-4 days. Measurement of
reticulocyte hemoglobin content in peripheral blood samples is useful for patient with chronic
anemia, this clinical value offer significantly faster control during iron and erythropoietin
therapy.

© 2012 Mindray
59 Confidential
 RPI: Reticulocyte Production Index

01 RPI can correct the RET

parameter
Anemia → EPO ↑ → reticulocytes
into the blood in advance →
peripheral blood reticulary mature
time to extend → RET ↑
02 Evaluation of hematopoietic capacity

03 Monitoring the effect of iron

deficiency anemia

04 Predictive hematopoietic remodeling

RPI is the first to recover from the 12th
day after transplantation, ahead of other
indicators for more than 1 week
RET % ∗ HCT
𝑅𝑃𝐼 =
0.45 ∗ Residence RET ∈the blood
 RBC Fragment count(FRC#,%)

Microscopic more than 500 RBC

FRC*
Diagnosis for hemolytic anemia

Disseminated Intravascular
Coagulation, DIC

FRC*
© 2012 Mindray
61 Confidential
 Body fluid analysis
BC-6200/6000 can analysis Peritoneal fluid, Cerebrospinal Fluid, Pleural fluid and synovial fluid to provide
reportable parameter for RBC, WBC,WBC differential (polymorphonuclear &mononuclear) and total cell count(TC-
BF)

Moreover, for research use only, BC-6200/6000 provides differential results for eosinophils, neutrophils as well as
high fluorescent cells (HF-BF*), which may include histiocytes, epithelial cells, spleen cells, ex-foliated cells etc.
Such additional information improves the possibility of better clinical diagnosis.

© 2012 Mindray
62 Confidential
 HGB larger detector

Small
detector

Normal sample High WBC, lipid sample

Accurate result Inaccurate result

Large
detector

Normal sample High WBC, lipid sample

Accurate result Accurate result
Stronger HGB lyse

Ordinary HGB lyse Stronger HGB lyse

High WBC sample High WBC sample

Inaccurate result Accurate result

Straight emitting light, parallel surface for HGB reaction bath, stronger LH
lyse, large photo detector ensure more accurate HGB result. Plus, they
can minimize the interference from lipid samples and high WBC samples.
 Operation

Value Operation Cost

 Automatic Rerun
Perfect fusion of intelligence and clinical value

Automatic reflex measurement in case of abnormal results, No additional manual

intervention ,the BC-6200/6000 can rerun the samples for an automatic rerun & reflex check.
© 2012 Mindray
66 Confidential
Reagent replacement faster
Reagent
replacement
time saving 50%

1 2 3

Reagent Improve work

storage tank efficiency
New working procedure with labXpert brings efficiency

More powerful More efficiency

More simpler More value

 Pre-defined Validation Rules

Critical Value Abnormal range

Delta Check
Parameter
Clinical Exception
& Flag

Normal range
Automated
Delta Check
Manual review
Conditions Microscopic Exam.
Conditions

Manual validation

69
More Intuitive labXpert software
Daily workload

Flags
Patient
Information
Graphics

Expert
Sample Historic Tips
results results

Sample Procedure
Re-exam
rules

All necessary information on one screen ensure your manual validation easier
Applicable to variety of tubes

Microtainer
tube

Vacuum Sarstedt
collective tube
tube
Body fluid

Cerebrospinal Fluid (CSF)

Peritoneal fluid
Body fluid

Pleural fluid
Synovial fluid
Reagent alarm system

Detecting sensor

Reagent inlet

The bubble detection reagent sensors give timely alarms when reagents are insufficient.
Additionally reagent sensors plus software calculation ensure lower dead volume.
Reagent sensors for fluorescent reagents

The 3 fluorescent reagents equipped with reagent sensors. The sensors are
monitoring the bubbles in the tube, this makes stable reagents aspiration
and lower dead volume.
More flexible operation

Vacuum collective tube Micro tube Automatic switch

 Cost

Value Operation Cost

Minimal sample volume

Whole blood Capillary blood Predilute body fluid

80uL 35uL 20uL 85uL

Minimal sample volume reduce the pain of the patient
Reduce the reagent consumption

Compared with BC-6800, reagent consumption decreased by 10%

© 2012 Mindray
78 Confidential
Smaller footprint

30% ↓by footprint

672mm 826mm
680 mm 850mm

In the same grade analyzer, the fastest throughput and the smallest footprint
Touch screen

BC-6200/6000 can be connected to the LIS directly; touch screen operation, no

extra computer
 Reservation

Analysis Review QC Reagent Dilute Print

On Finished time Off time

Mon
Tue
Wed

Thu
Fri
Sat
Sun
The analyzer will start 20 minutes in advance

Without waiting, Reservation make your everyday work easier

© 2012 Mindray
81 Confidential
 Cost reduction in quality control

Quality Control
BC-6D (H, N, L)
BC-RET (H, N, L)

Calibrator
SC-CAL PLUS

Quality control costs will be reduced by 30%

Voice Of the Customer

Value Operation Cost

Marketing position
>400

Core laboratory
CAL 8000 University hosp

3-part 5-part
>240

BC-6800Plus
Medium to
Large hospital
Samples per day

BC-6800
>120

BC-6200
BC-6000 Small to
BC-5800 Medium hospit
BC-5390

BC-5380

BC-5300
>60

BC-5150
BC-5000
Primary care
BC-3600
BC-30s small hospital
BC-3000plus
BC-20s
BC-2800
>20

BC-2300 3 diff CBC+5 diff RET+NRBC Extended parameters

& automation line

Capability

84
 Tibet Plateau

Thank You!
© 2012 Mindray
85 Confidential