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    Enzymes Lecture

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    jsyl2009

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    © All Rights Reserved
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    Enzymes Lecture

    Uploaded by

    jsyl2009
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    1 views23 pages

    Enzymes Lecture

    Uploaded by

    jsyl2009

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    You are on page 1of 23

    Lecture: Intro to

    Enzymes
    Review: Reactions
    Enzymes
     Specific,
    catalytic proteins – speed
    up reactions without being
    consumed
    Enzymes
    How They Work
     Substrate = key, enzyme = lock,
    active site = keyhole
     Substrate enters active site, enzyme
    binds  forms enzyme-substrate
    complex
    How They Work
     The active site lowers
    the activation energy
    by:
     Orienting substrates
    correctly
     Straining substrate
    bonds
     Providing a favorable
    microenvironment
    The Catalytic Cycle
    1. Induced-Fit 2. Held by hydrogen
    Complex bonds

    3. Active site
    lowers activation
    energy
    6. Active
    site reset

    5. Products
    released 4. Substrates
    converted to products
    Denaturation
     Proteins unravel and loses its shape
    Lecture: Effects on
    Enzymatic Activity
    Enzyme Activity
     Affected by environmental factors:
     pH
     Temperature
     Enzyme concentration
     Substrate concentration
    Temperature
    pH
    Enzyme Concentration
    Substrate
    Concentration
    Substrate Concentration
    Analogy 1
    Substrate
    Concentration
    Cofactors &
    Coenzymes
    Allosteric Regulation

    Allosteric Allosteric
    Activator Inhibitor
    Enzyme Inhibitors
    Enzyme Inhibitors
    Can You & Your
    Partner…
     Explain how do temperature
    and pH affect enzyme
    activity?
     Explain why adding substrates
    continuously slows
    down/steadies the rate of
    reaction?
     Distinguish between allosteric
    regulation and competitive
    inhibitors?
     Think of at least one question
    to answer during Q&A?
    Time for Questions!

    Will
    Would Why

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