In the study by Henze et al.,22 more than 30% of patients had elevated testosterone or
DHEAS levels.
[1] Nonstandard abbreviations: ACC, adrenocortical carcinoma; LC-MS/MS, Liquid chromatography-tandem mass spectrometry; APCI, atmospheric pressure chemical ionization; ESI, electrospray ionization; IS, internal standard; APPI, atmospheric pressure photoionization;
DHEA, dehydroepiandrosterone;
DHEAS,
DHEA sulfate.
The steroid hormones analyzed included pregnenolone, 17a-hydroxyprogesterone, and corticosterone, which are produced in the zona glomerulosa (ZG) and zona fasciculate (ZF), as well as dehydroepiandrosterone (
DHEA), androstenedione, and free testosterone of the zona reticularis (ZR) of the adrenal cortex.
Dehydroepiandrosterone (
DHEA) rather than testosterone shows saliva androgen responses to exercise in elite female handball players.
New studies are pointing to a novel way of protecting the aging mind: supplementation with
DHEA.
On the contrary,
DHEA and its sulfated form (DHEA-S) are the major circulating neurosteroids that have neuroprotective, (3,4) antioxidant, (5) and anti-inflammatory (6) effects on the brain.
Systemic inhibition of G6PD induces a severe autoinflammatory reaction in dogs, and potentially in other species that have evolved circulating
DHEAS, but not in rats and mice.
Levels of
DHEA (the unsulfated form of
DHEAS) have been generally reported to be inversely associated with pain and to produce possible analgesic effects.
Blood glucose (mg/dl), insulin ([micro]IU/ml), follicle-stimulating hormone (FSH) ([micro]IU/ml), luteinizing hormone (LH) ([micro]IU/ml), Estradiol (E2) (pg/ml), prolactin ([micro]IU/ml),
DHEAS (mcg/dl), thyroid-stimulating hormone (TSH) ([micro]IU/ml), triiodothyronine (T3) (nmol/L), thyroxine (T4) (nmol/L), 17 OH-progesterone (ng/ml), total testosterone (nmol/L), free testosterone (pg/ml), triglyceride (mg/dl), LDL cholesterol (mg/dl), and HDL cholesterol (mg/dl) levels of patients with PCOS and healthy women participants were measured from fasting blood samples on an Abbott I2000 SR immunology analyzer and Olympus AU 400 autoanalyzer.
Free T and
DHEAS were found to be statistically higher in the cases (2.78 [+ or -] 1.24 pg/mL and 231.50 [+ or -] 127.20 [micro]/dL) when compared to the control group (1.50 [+ or -] 0.75 pg/mL and 133.59 [+ or -] 60.69 [micro]/dL) (P = 0.0001 and 0.001, resp.).
However, such AA steroid relations, like lower dehydroepiandrosterone sulfate (
DHEAS) levels, were not observed in the two other cohort studies [6, 12].
In pubertal girls from an area of intense transmission in western Kenya,
DHEAS level was significantly associated with decreased parasite density (even after adjustment for age) and was also positively correlated with haemoglobin level (Leenstra et al.