p53

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p53

(pē′fĭf′tē-thrē′)

1. A protein that regulates normal cell growth and proliferation and prevents unrestrained division of cells whose DNA has been damaged, as from ultraviolet or ionizing radiation. The absence of functional p53, usually resulting from a genetic mutation, increases the risk of developing various cancers.

2. The tumor suppressor gene that codes for this protein. Also called TP53.

[p(rotein) 53, from its apparent molecular mass of 53 kilodaltons as extrapolated from its mobility during electrophoresis.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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References in periodicals archive ?

The findings explain p53's involvement in a molecular process specific to females called 'X chromosome inactivation'.

Study finds cancer-fighting gene to prevent birth defects

The tumor suppressor p53 has critical checkpoint functions that sense DNA damage and inappropriate growth signals, and p53 is capable of transcriptionally activating a series of genes involved in cell cycle arrest and apoptosis.

Grail suppresses stress-induced apoptosis and colony formation in oral cancer cells

Search for a description of "p53" and it becomes clear that this human protein is widely known for its cancer-fighting benefits, leading to its renown as "the guardian of the genome."

Tumor-Fighting Protein Also Boosts Cancer Growth

'yun pala sa pag recheck nung mga nai-print na proyekto, P53 billion pala dyan hindi nila kailangan o hindi nila hinihingi.

Andaya: P53 B DPWH budget insertion uncovered

The regulatory mechanism associated with p53 was also confirmed to enrich the experimental evidence for oridonin as a tumor suppressor in GC.

Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function

The p53 gene was involved in numerous pathways, which were interlinked for progression of CaP.

Evaluation of correlation between expression of P53 and Malondialdehyde levels in prostate cancer patients

This is the peso's lowest level since it ended at P53.985 versus the dollar on Dec.

DOF: Countries with most depreciated currencies are among the fastest growing

Both PD-L1 and p53 play important roles in tumor development.

Correlation between Programmed Death-1 Ligand-1 and p53 in Patients with Lung Adenocarcinoma

"By picking cells that have successfully repaired the damaged gene we intended to fix, we might inadvertently also pick cells without functional p53," says Dr.

Genome-editing tool could increase cancer risk

The secondary biomarker p53 has been studied at various centers in the world and has been found to be deregulated in cervical cancers.

A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India

"Many publications have used immortalized cells as MSC surrogates, but they may not mean much if they don't have functionally accurate p53," said Siddaraju Boregowda, one of the study's two lead authors.