Toll-like receptors and innate immunity (Q29615458)

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scientific article (publication date: November 2001)

Language	Label	Description	Also known as
English	Toll-like receptors and innate immunity	scientific article (publication date: November 2001)

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scholarly article

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Europe PubMed Central

Toll-like receptors and innate immunity (English)

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30 April 2017

toll-like receptor

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Ruslan Medzhitov

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object named as

Medzhitov R

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30 April 2017

language of work or name

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30 April 2017

publication date

November 2001

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30 April 2017

Nature Reviews Immunology

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30 April 2017

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135-45

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30 April 2017

Approaching the asymptote? Evolution and revolution in immunology

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https://api.crossref.org/works/10.1038%2F35100529

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The immune system evolved to discriminate infectious nonself from noninfectious self

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Innate immunity: impact on the adaptive immune response

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The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

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7 January 2021

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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A family of human receptors structurally related to Drosophila Toll

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7 January 2021

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Proteins with leucine-rich repeats

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Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons

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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

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7 January 2021

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

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7 January 2021

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MyD88, an adapter protein involved in interleukin-1 signaling

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7 January 2021

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TIRAP: an adapter molecule in the Toll signaling pathway

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7 January 2021

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Toll signaling pathways in the innate immune response

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A conserved signaling pathway: the Drosophila toll-dorsal pathway

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7 January 2021

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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

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Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor

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7 January 2021

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The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila

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7 January 2021

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Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila

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7 January 2021

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Drosophila immunity: two paths to NF-kappaB.

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https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

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7 January 2021

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A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense

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7 January 2021

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Signaling mechanisms in the antimicrobial host defense of Drosophila

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https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis

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https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Interactions between the cellular and humoral immune responses in Drosophila

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7 January 2021

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The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

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https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.

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7 January 2021

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A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity

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7 January 2021

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Role of Drosophila IKK gamma in a toll-independent antibacterial immune response

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7 January 2021

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Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses

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7 January 2021

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Relish, a central factor in the control of humoral but not cellular immunity in Drosophila

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7 January 2021

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Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila

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https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

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7 January 2021

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Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Toll-related receptors and the control of antimicrobial peptide expression in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Toll-like receptors: critical proteins linking innate and acquired immunity

1 reference

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7 January 2021

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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7 January 2021

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Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

1 reference

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7 January 2021

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Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

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7 January 2021

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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

1 reference

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7 January 2021

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Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling

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7 January 2021

based on heuristic

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Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation

1 reference

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7 January 2021

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Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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The molecular mechanism of B cell activation by toll-like receptor protein RP-105

1 reference

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7 January 2021

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The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

1 reference

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7 January 2021

based on heuristic

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells

1 reference

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7 January 2021

based on heuristic

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

1 reference

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7 January 2021

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A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

1 reference

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7 January 2021

based on heuristic

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Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

1 reference

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7 January 2021

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Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite

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7 January 2021

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Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

1 reference

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7 January 2021

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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

1 reference

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7 January 2021

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Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Discrimination of bacterial lipoproteins by Toll-like receptor 6

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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PKR; a sentinel kinase for cellular stress

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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JNK2 and IKKbeta are required for activating the innate response to viral infection

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

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7 January 2021

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Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling

1 reference

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7 January 2021

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Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression

1 reference

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7 January 2021

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A Toll-like receptor recognizes bacterial DNA

1 reference

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7 January 2021

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CpG motifs in bacterial DNA trigger direct B-cell activation

1 reference

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7 January 2021

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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Transport of bacterial lipopolysaccharide to the golgi apparatus

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of CpG motifs in innate immunity

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Induction of direct antimicrobial activity through mammalian toll-like receptors

1 reference

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7 January 2021

based on heuristic

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Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

inferred from DOI database lookup

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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IRAK: a kinase associated with the interleukin-1 receptor

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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TRAF6 is a signal transducer for interleukin-1

1 reference

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7 January 2021

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1 reference

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7 January 2021

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

based on heuristic

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Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

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7 January 2021

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://api.crossref.org/works/10.1038%2F35100529

7 January 2021

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Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

1 reference

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7 January 2021

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Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

1 reference

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7 January 2021

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Endotoxin-induced maturation of MyD88-deficient dendritic cells

1 reference

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7 January 2021

based on heuristic

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Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta

1 reference

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7 January 2021

based on heuristic

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

1 reference

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7 January 2021

based on heuristic

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Dendritic cells and the control of immunity

1 reference

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7 January 2021

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Toll-like receptors control activation of adaptive immune responses

1 reference

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7 January 2021

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Pentraxin family of proteins interact specifically with phosphorylcholine and/or phosphorylethanolamine

1 reference

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7 January 2021

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The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity

1 reference

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7 January 2021

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Scavenger receptors in innate immunity

1 reference

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7 January 2021

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Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages

1 reference

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7 January 2021

based on heuristic

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Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

1 reference

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7 January 2021

based on heuristic

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Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB

1 reference

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7 January 2021

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Identifiers

10.1038/35100529

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821

30 April 2017

Consolidated OpenCitations Corpus – April 2017

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1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821

30 April 2017

Consolidated OpenCitations Corpus – April 2017

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