Nuclear receptor coactivator 3 (Q2364112)

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mammalian protein found in Homo sapiens
  • class E basic helix-loop-helix protein 42
  • NCOA3
  • CBP-interacting protein
  • SRC-3
  • bHLHe42
  • TRAM-1
  • receptor-associated coactivator 3
  • nuclear receptor coactivator 3
  • RAC-3
  • ACTR
  • steroid receptor coactivator protein 3
  • AIB-1
  • pCIP
  • amplified in breast cancer 1 protein
  • thyroid hormone receptor activator molecule 1
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Language Label Description Also known as
English
Nuclear receptor coactivator 3
mammalian protein found in Homo sapiens
  • class E basic helix-loop-helix protein 42
  • NCOA3
  • CBP-interacting protein
  • SRC-3
  • bHLHe42
  • TRAM-1
  • receptor-associated coactivator 3
  • nuclear receptor coactivator 3
  • RAC-3
  • ACTR
  • steroid receptor coactivator protein 3
  • AIB-1
  • pCIP
  • amplified in breast cancer 1 protein
  • thyroid hormone receptor activator molecule 1

Statements

part of
molecular function
protein binding
determination method or standard
IPI
22 references
retrieved
8 April 2019
stated in
FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors
GOA
curator
UniProt
UniProt protein ID
Q9Y6Q9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation
GOA
curator
UniProt
UniProt protein ID
Q9Y6Q9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription
GOA
curator
UniProt
UniProt protein ID
Q9Y6Q9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
GOA
curator
UniProt
UniProt protein ID
Q9Y6Q9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor
GOA
curator
UniProt
UniProt protein ID
Q9Y6Q9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Enhancer activation requires trans-recruitment of a mega transcription factor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A large set of estrogen receptor β‐interacting proteins identified by tandem affinity purification in hormone‐responsive human breast cancer cell nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of rapid oestrogen signalling in aggressive human breast cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Progesterone receptor modulates ERα action in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
retrieved
8 April 2019
stated in
The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6Q9
determination method or standard
IPI
cell component
biological process
Gene Atlas image
PBB GE NCOA3 207700 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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