X-linked inhibitor of apoptosis (Q3408221)

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mammalian protein found in Homo sapiens
  • hIAP-3
  • X-linked inhibitor of apoptosis protein
  • ILP
  • IAP-like protein 1
  • inhibitor of apoptosis protein 3
  • hILP
  • IAP-3
  • IAP-like protein
  • E3 ubiquitin-protein ligase XIAP
  • X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
  • RING-type E3 ubiquitin transferase XIAP
  • XIAP
  • X-linked IAP
  • hIAP3
  • baculoviral IAP repeat-containing protein 4
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Language Label Description Also known as
English
X-linked inhibitor of apoptosis
mammalian protein found in Homo sapiens
  • hIAP-3
  • X-linked inhibitor of apoptosis protein
  • ILP
  • IAP-like protein 1
  • inhibitor of apoptosis protein 3
  • hILP
  • IAP-3
  • IAP-like protein
  • E3 ubiquitin-protein ligase XIAP
  • X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
  • RING-type E3 ubiquitin transferase XIAP
  • XIAP
  • X-linked IAP
  • hIAP3
  • baculoviral IAP repeat-containing protein 4

Statements

molecular function
protein binding
determination method or standard
IPI
36 references
retrieved
9 May 2019
stated in
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization
GOA
curator
UniProt
UniProt protein ID
P98170
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling
GOA
curator
UniProt
UniProt protein ID
P98170
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2
GOA
curator
UniProt
UniProt protein ID
P98170
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination
GOA
curator
UniProt
UniProt protein ID
P98170
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
A novel role for XIAP in copper homeostasis through regulation of MURR1
GOA
curator
UniProt
UniProt protein ID
P98170
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Molecular interaction between HAX-1 and XIAP inhibits apoptosis
GOA
curator
UniProt
UniProt protein ID
P98170
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Survivin monomer plays an essential role in apoptosis regulation
GOA
curator
UniProt
UniProt protein ID
P98170
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Dual regulatory switch confers tighter control on HtrA2 proteolytic activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Mechanism of XIAP-mediated inhibition of caspase-9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
ARTS and Siah collaborate in a pathway for XIAP degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Structural Basis of Caspase Inhibition by XIAP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Structural basis of caspase-7 inhibition by XIAP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
XIAP mediates NOD signaling via interaction with RIP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Structural basis of IAP recognition by Smac/DIABLO
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Structural basis for the inhibition of caspase-3 by XIAP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Identification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
retrieved
9 May 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98170
determination method or standard
IPI
cell component
biological process
Gene Atlas image
PBB GE BIRC4 206536 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D051636
subject named as
X-Linked Inhibitor of Apoptosis Protein
0 references
PDB structure ID
 
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