NIPBL cohesin loading factor (Q6954349)

Armadillo-like helical

1 reference

Armadillo-type fold

1 reference

Sister chromatid cohesion C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HEAT repeat associated with sister chromatid cohesion protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

mediator complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

chromo shadow domain binding

1 reference

8 April 2019

The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

protein N-terminus binding

1 reference

8 April 2019

Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

histone deacetylase binding

1 reference

8 April 2019

The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

protein C-terminus binding

1 reference

8 April 2019

The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

protein binding

6 references

8 April 2019

Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

8 April 2019

In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

8 April 2019

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

8 April 2019

Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

8 April 2019

Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

chromatin binding

3 references

1 reference

8 April 2019

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

1 reference

8 April 2019

TAS

chromatin

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6KC79&geneProductId=UniProtKB:Q6KC79

extracellular exosome

1 reference

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6KC79&geneProductId=UniProtKB:Q6KC79

nuclear chromosome

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

8 April 2019

Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

1 reference

8 April 2019

extracellular exosome

HDA

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

positive regulation of histone deacetylation

HDA

biological process

1 reference

8 April 2019

The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

forelimb morphogenesis

1 reference

8 April 2019

Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

eye morphogenesis

1 reference

8 April 2019

de Lange syndrome: a clinical review of 310 individuals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

regulation of embryonic development

1 reference

8 April 2019

Cornelia de Lange syndrome (CdLS): prenatal and autopsy findings

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

cognition

1 reference

8 April 2019

Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

uterus morphogenesis

1 reference

8 April 2019

Cornelia de Lange syndrome (CdLS): prenatal and autopsy findings

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

cellular response to X-ray

1 reference

8 April 2019

Increased DNA damage sensitivity of Cornelia de Lange syndrome cells: evidence for impaired recombinational repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

regulation of developmental growth

1 reference

8 April 2019

Cornelia de Lange syndrome (CdLS): prenatal and autopsy findings

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

heart morphogenesis

1 reference

17 October 2017

de Lange syndrome: a clinical review of 310 individuals

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6KC79&geneProductId=UniProtKB:Q6KC79

outflow tract morphogenesis

1 reference

8 April 2019

Cornelia de Lange syndrome (CdLS): prenatal and autopsy findings

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

positive regulation of ossification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

hearing

1 reference

8 April 2019

Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

cellular response to DNA damage stimulus

1 reference

8 April 2019

Increased DNA damage sensitivity of Cornelia de Lange syndrome cells: evidence for impaired recombinational repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

stem cell population maintenance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

ear morphogenesis

1 reference

8 April 2019

de Lange syndrome: a clinical review of 310 individuals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

heart development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6KC79&geneProductId=UniProtKB:Q6KC79

brain development

1 reference

17 October 2017

de Lange syndrome: a clinical review of 310 individuals

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6KC79&geneProductId=UniProtKB:Q6KC79

developmental growth

1 reference

8 April 2019

Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

regulation of hair cycle

1 reference

8 April 2019

Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

positive regulation of multicellular organism growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

gall bladder development

1 reference

8 April 2019

Cornelia de Lange syndrome (CdLS): prenatal and autopsy findings

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

1 reference

8 April 2019

embryonic cranial skeleton morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

embryonic viscerocranium morphogenesis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6KC79&geneProductId=UniProtKB:Q6KC79

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

1 reference

8 April 2019

metanephros development

NAS

1 reference

8 April 2019

NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

negative regulation of transcription, DNA-templated

NAS

1 reference

8 April 2019

The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

maintenance of mitotic sister chromatid cohesion

1 reference

8 April 2019

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6KC79&geneProductId=UniProtKB:Q6KC79

1 reference

17 October 2017

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6KC79&geneProductId=UniProtKB:Q6KC79

1 reference

17 October 2017

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

1 reference

8 April 2019

mitotic sister chromatid cohesion

1 reference

17 October 2017

Precocious sister chromatid separation (PSCS) in Cornelia de Lange syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6KC79&geneProductId=UniProtKB:Q6KC79

double-strand break repair

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

mitotic chromosome condensation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

establishment of mitotic sister chromatid cohesion

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

rDNA condensation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

establishment of protein localization to chromatin

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

positive regulation of mitotic cohesin loading

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

replication-born double-strand break repair via sister chromatid exchange

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6KC79

Sister chromatid cohesion C-terminal domain

has part(s)

1 reference

HEAT repeat associated with sister chromatid cohesion protein

1 reference