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- gadd7 (growth arrested DNA-damage inducible gene 7) is a non-coding RNA discovered in the ovaries of the chinese hamster (Cricetulus griseus). Homologs have been identified in the closely related Long-tailed Dwarf Hamster (C. longicaudatus). Although the gene for this RNA contains open reading frames, translation studies found no protein product hence gadd7 has been classified as non-coding RNA. gadd7 was previously characterised as a hydrogen peroxide-inducible transcript but has more recently been linked with lipotoxicity - where the accumulation of lipids in non-adipose tissue brings about cell death. gadd7 appears to be a key element in the lipotoxicty pathway, when it is knocked out the resulting mutant is much more resistant to oxidative stress. The proposed mechanism for gadd7's role in lipotoxicity is: 1.
* The lipid palmitate builds to high concentration within a cell 2.
* Reactive oxygen species (ROS) are generated 3.
* This stress induces the expression of gadd7 4.
* A feed-forward mechanism occurs 5.
* ER stress brings about death of the cell (en)
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- Conserved secondary structure of gadd7 RNA (en)
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- gadd7 (en)
- growth arrested DNA-damage inducible gene 7 (en)
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- gadd7 (growth arrested DNA-damage inducible gene 7) is a non-coding RNA discovered in the ovaries of the chinese hamster (Cricetulus griseus). Homologs have been identified in the closely related Long-tailed Dwarf Hamster (C. longicaudatus). Although the gene for this RNA contains open reading frames, translation studies found no protein product hence gadd7 has been classified as non-coding RNA. The proposed mechanism for gadd7's role in lipotoxicity is: (en)
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