Since its release, mNeonGreen has been available exclusively at
Allele biotechnology, under a novel licensing model created by
Allele specifically for academic users (Nature Methods: Technology Feature).
FOXO3 controls the expression of multiple genes regulating cell survival, autophagy, cell proliferation and metabolism which ultimately results in stress resistance, nutrient sensing and tumor suppression in various cells and tissues.5 FOXO3 also plays an essential role in preventing various age-related diseases such as type 2 diabetes mellitus, cardiovascular diseases, neurodegenerative disorders and cancers.3 Various single nucleotide polymorphisms (SNPs) of FOXO3 gene have been observed to be associated with multiple age-related diseases and longevity.6 Among these SNPs, the minor
allele "A" of rs2802288 is particularly found to be associated with longevity and healthy aging in individuals.7,8 The far reaching effects of FOXO3 warrant detailed study of this gene.
Allele frequency is to display gene diversity in one population of one species.
Fetuin-A is encoded by the AHSG gene located at the chromosome 3q27, composed of seven exons and spanning 8.2 kb of deoxyribonucleic acid (DNA).7 The gene has multiple variants but the specific
allele of interest for this study is rs4918.
Because of the low genetic diversity at Glu-D3, no
allele specific markers were developed (Liu et al., 2010), and the effect of Glu-D3 on bread making quality is also negligible as compared to other Glu-3 loci (Gupta et al., 1989; Zhang et al., 2012).
In addition, the etiologic fraction (EF) was calculated to determine how much each
allele, genotype, or haplotype contributed to susceptibility to CR.
Conclusions: Data demonstrates that frequency and distribution of mutant T
allele was more prevalent as compared to wild type A
allele in the study group.
We used the DNA Isolation Kit for Blood/Bone Marrow/Tissue (Roche Molecular Diagnostics, Meylan, France) to extract DNA, and the specific single-stranded oligonucleotide probe (SSO) technique with the Dynal RELI SSO (Invitrogen, Wirral, United Kingdom) HLA-DRB typing kit for
allele typification in all samples.
Allele has developed proprietary techniques to generate iPSCs and to derive high quality tissue-specific cells with much less technical difficulties than other known methods.
Allele has developed proprietary techniques to generate iPSCs and to derive high quality tissue specific cells with much less technical difficulties than other known methods.
In CD patients, the mutant
allele (T) and genotype (AT+TT) of FUT2 A385T were less prevalent in patients with ileocolonic CD than in colonic CD (41.67% versus 59.41%, P = 0.001, OR = 0.488, and 95% CI = 0.324-0.734; 63.33% versus 83.17%, P = 0.002, OR = 0.350, and 95% CI = 0.178-0.686, resp.) (Table 4).
In the case that an
allele could not be fully phased using the default set of 4000 read-pairs, the number of read-pairs was increased to 16000.
In this study, with the support of clinical data, we were able to investigate the HLA - DRB1
allele frequencies in NPC patients and healthy controls, as well as in several clinical and pathological subgroups of NPC in Han and Uyghur subjects.
