To date, rare genetic variants in multiple genes have been discovered in familial IPF, which mainly be subdivided into two categories as follows: genes related to surfactant protein metabolism and genes that maintain telomere length.[6] Germline defects in telomere maintenance are common in IPF, several genes in the telomere maintenance pathway have been implicated in IPF families, including those that affect
telomerase catalytic activity ( TERT, TERC ), telomere biogenesis ( DKC1, PARN, NAF1 ) or telomere end regulation ( TINF2, RTEL1 ).
* To compare telomere length and
telomerase activity in hypertensive male patients aged between 45 and 65 years with age-matched healthy controls.
The amazing thing about
telomerase is that it can actually lengthen your telomeres.
But
telomerase is also highly active in cancer cells, keeping their telomeres intact and making the cells virtually immortal.
"Our findings provide a structural framework for understanding human
telomerase disease mutations, and represent an important step towards telomerase-related clinical therapeutics."
They have backup in the form of an enzyme known as
telomerase, which tries to delay the decline as long as possible by replenishing the telomeres.
Understanding the underlying mechanism of
telomerase action offers new avenues toward effective anti-aging therapeutics.
Telomerase activity was found to be high in the male germ line but low or absent in mature oocytes and cleavage stage embryos and then high again in blastocyst stage embryos [21-23].
The researchers suspected that oxidative damage would render
telomerase unable to do its job.
Methods: Human
telomerase reverse transcriptase, pontin, reptin and dyskerin expressions were measured in normal and tumour tissues obtained from 26 patients with colorectal, breast and gastric cancers, using the realtime reverse transcriptase-polymerase chain reaction method.
In a five-year study led by pathologist Jianyu Rao, MD, UCLA Jonsson Comprehensive Cancer Center, researchers found that a Chinese herbal regimen called TSY-1 (Tianshengyuan-1) increased activity of an enzyme called
telomerase. This enzyme is responsible for the production of telomeres, which help regulate cell division.
We hypothesized that IL-6 and TNF-[alpha] contribute to the cancer initiation and progression by promoting cancer stemness and
telomerase activity.
Cells naturally contain an enzyme called
telomerase, which adds new DNA to the ends of telomeres, helping to keep them long enough to support cellular activities.
Tamoxifen is shown in the literature to be a
telomerase activator [7].
His most recent book, "The
Telomerase Revolution," was lauded in a review by The London Times.
