Papers by Ibrahim Ibrahim
Non-communicable diseases have now become a serious threat to global health, including diabetes. ... more Non-communicable diseases have now become a serious threat to global health, including diabetes. in reports from Sungai Geringging Public Health Center in 2020 the prevalence of diabetes mellitus was 450 people. Checking blood sugar levels in diabetic patients should be done regularly. Examination of blood glucose levels using the glucose oxidase method, examination materials in the form of venous blood and capillary blood. This study aims to determine the comparison of glucose levels in capillary and venous blood using a glucometer in patients with diabetes mellitus. This type of quantitative research was carried out at Sungai Geringging Public Health Center, Padang Pariaman Regency, and carried out in February 2021. The population of patients who did blood glucose checks with a sample of 81 people. Data analysis was univariate and bivariate using a t-test. The results of capillary blood glucose levels were 203.507 mg/dl, glucose levels in venous blood were 199.753 mg/dl. There is ...
Expert Review of Clinical Immunology, 2012
Background Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease that is character... more Background Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease that is characterized by inflammation of the synovium. In its active form, RA leads to swelling, tenderness and the progressive destruction of joints. Treatment in the first instance is focused around the use of steroids and disease-modifying anti rheumatic drugs (DMARDs), such as methotrexate (MTX). More recently, biological therapies that block the TNF pathway (anti-TNF drugs) have emerged as more effective, especially in cases where RA is refractory to treatment with DMARDs [1]. Such biological therapies have been shown to slow disease progression, reduce inflammation and improve symptoms, but are much more expensive (~£8000–10,000 per patient per year) compared with MTX (~£35 per patient per year) [2,101]. There is also a significant nonresponse rate to both drugs: MTX 45% and anti-TNF 23% by 48 weeks [3,4]. Furthermore, both drugs are also associated with serious adverse events (AEs); for example, MTX is associated with hepatotoxicity and pneumonitis, while anti-TNF drugs increase the risk of serious infections. However, the introduction of early, effective therapy has consistently been shown to improve the long-term outcomes of RA including joint damage, disability and employment [5–7]. Thus, achieving the right treatment in the first instance is essential in order to deliver improved and more cost-effective outcomes for patients with RA, a goal that would no doubt be facilitated by the identification of predictors of treatment response. Past Some predictors for response to each drug have already been identified. For example, baseline disability (assessed by the health assessment questionnaire), concurrent DMARD therapy, gender, rheumatoid factor and anti-cyclic citrullinated peptide antibody status all correlate with response to anti-TNF drugs and, together, account for approximately 17% of the variability of response [8]. However, this is not sufficiently predictive to be of use in clinical practice, and recent years have seen a significant focus being placed on the identification of genetic and genomic predictors [9]. The actions of many drugs are determined by their effect on particular genes and biological pathways, and this is where genetic variants would make ideal biomarkers of response, as they are stable, easily measured and inexpensive to assess.
Journal of Agricultural and Food Chemistry, 2004
Clinical Neurology and Neurosurgery, 2008
To analyze the impact of the lunar cycle and season on the incidence of aneurysmal subarachnoid h... more To analyze the impact of the lunar cycle and season on the incidence of aneurysmal subarachnoid hemorrhage (SAH). The medical records of 111 patients who were admitted over a 5-year period to our department because of aneurysmal SAH were retrospectively reviewed. The date of aneurysm rupture was matched with the corresponding season and moon phase. An incidence peak for aneurysm rupture (28 patients) was seen during the phase of new moon, which was statistically significant (p < 0.001). In contrast, no seasonal variation in the incidence of SAH was observed. The lunar cycle seems to affect the incidence of intracranial aneurysm rupture, with the new moon being associated with an increased risk of aneurysmal SAH.
Bioresource Technology, 2012
AFRICAN JOURNAL OF BIOTECHNOLOGY, 2012
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Papers by Ibrahim Ibrahim