Nucleus accumbens

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[Labus et al 2018] 2018; Food intake, metabolites, reward center. Microbiota-derived indole metabolites may influence hedonic food intake and obesity by acting on extended reward network (amygdala-nucleus accumbens circuit and the amygdala-anterior insula circuit).  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201772 Human Health And Disease, Caudate Nucleus, Graph Theory, Nucleus Accumbens, Brain Stem, Gut Microbiota, Subjects, Circuit, Brain

Objective A growing body of preclinical and clinical literature suggests that brain-gut-microbiota interactions play an important role in human health and disease, including hedonic food intake and obesity. We performed a tripartite network analysis based on graph theory to test the hypothesis that microbiota-derived fecal metabolites are associated with connectivity of key regions of the brain’s extended reward network and clinical measures related to obesity. Methods DTI and resting state…

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These yellow structures are adenosine A2A receptors in the shell of the nucleus accumbens of the brain. As we become tired, our bodies produce adenosine (the green small molecule above), which binds to these receptors and they, in turn, send signals to inhibit arousal. In other words, we get sleepy. Enter caffeine! (the orange small molecule above). Caffeine binds to the A2A receptors in place of adenosine and blocks the process, so we wake up! Nucleus Accumbens, The Brain, Our Body, Wake Up, Brain, This Is Us, Science, Turn Ons, Orange

These yellow structures are adenosine A2A receptors in the shell of the nucleus accumbens of the brain. As we become tired, our bodies produce adenosine (the green small molecule above), which binds to these receptors and they, in turn, send signals to inhibit arousal. In other words, we get sleepy. Enter caffeine! (the orange small molecule above). Caffeine binds to the A2A receptors in place of adenosine and blocks the process, so we wake up!

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