G6PD

G6PD
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1QKI, 2BH9, 2BHL
Dynodwyr
Cyfenwau	G6PD, G6PD1, glucose-6-phosphate dehydrogenase, Glucose-6-phosphate dehydrogenase
Dynodwyr allanol	OMIM: 305900 HomoloGene: 37906 GeneCards: G6PD
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • glucose binding; • GO:0001948, GO:0016582 protein binding; • NADP binding; • identical protein binding; • oxidoreductase activity; • carbohydrate binding; • glucose-6-phosphate dehydrogenase activity; • oxidoreductase activity, acting on CH-OH group of donors;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • cytoplasmic side of plasma membrane; • extracellular exosome; • cnewyllyn cell; • intracellular membrane-bounded organelle; • microtubule organizing center;
Prosesau biolegol	• NADP metabolic process; • GO:1904578 response to organic cyclic compound; • substantia nigra development; • glutathione metabolic process; • NADPH regeneration; • pentose-phosphate shunt, oxidative branch; • lipid metabolism; • regulation of neuron apoptotic process; • ribose phosphate biosynthetic process; • pentose biosynthetic process; • negative regulation of protein glutathionylation; • pentose-phosphate shunt; • glucose metabolic process; • response to food; • cellular response to oxidative stress; • cholesterol biosynthetic process; • glucose 6-phosphate metabolic process; • response to ethanol; • erythrocyte maturation; • positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; • negative regulation of reactive oxygen species metabolic process; • negative regulation of cell growth involved in cardiac muscle cell development; • response to iron(III) ion; • carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	2539
	n/a
	ENSG00000160211
	n/a
	P11413
	n/a
	NM_000402; NM_001042351; NM_001360016
	n/a
	NP_000393; NP_001035810; NP_001346945
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn G6PD yw G6PD a elwir hefyd yn Glucose-6-phosphate 1-dehydrogenase a Glucose-6-phosphate dehydrogenase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq28.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn G6PD.

G6PD1

Llyfryddiaeth

"Prevalence, genetic variants and clinical implications of G-6-PD deficiency in Burkina Faso: a systematic review. ". BMC Med Genet. 2017. PMID 29169341.
"Serum Soluble Transferrin Receptor Concentrations Are Elevated in Congolese Children with Glucose-6-Phosphate Dehydrogenase Variants, but Not Sickle Cell Variants or α-Thalassemia. ". J Nutr. 2017. PMID 28768839.
"Hemolytic Potential of Tafenoquine in Female Volunteers Heterozygous for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency (G6PD MahidolVariant) versus G6PD-Normal Volunteers. ". Am J Trop Med Hyg. 2017. PMID 28749773.
"Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development. ". J Infect Dis. 2017. PMID 28591790.
"Glucose-6-phosphate dehydrogenase enzyme stability in filter paper dried blood spots.". Clin Biochem. 2017. PMID 28479150.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] G6PD - Cronfa NCBI

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[2]