GNB1

GNB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4KFM, 4PNK, 3KRX, 3KRW, 1GG2, 1OMW, 1GP2, 3AH8, 1XHM, 1TBG, 3PSC, 3PVU, 3UZS, 3CIK, 3PVW, 3V5W, 5HE2, 5HE0, 5HE3, 5HE1
Dynodwyr
Cyfenwau	GNB1, G protein subunit beta 1, MRD42, MDS, HG2A
Dynodwyr allanol	OMIM: 139380 HomoloGene: 55532 GeneCards: GNB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • spectrin binding • type 1 angiotensin receptor binding • GO:0032403 protein-containing complex binding • signal transducer activity • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity • GTPase binding • G protein-coupled receptor binding • alkylglycerophosphoethanolamine phosphodiesterase activity Cydrannau o'r gell • extracellular vesicle • cell body • bilen • photoreceptor inner segment • myelin sheath • Cellbilen • photoreceptor outer segment • intracellular anatomical structure • lysosomal membrane • dendrite • photoreceptor disc membrane • heterotrimeric G-protein complex • photoreceptor outer segment membrane • extracellular exosome • cytosol Prosesau biolegol • cellular response to catecholamine stimulus • G protein-coupled acetylcholine receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • cellular response to glucagon stimulus • cellular response to prostaglandin E stimulus • platelet activation • cardiac muscle cell apoptotic process • phospholipase C-activating G protein-coupled receptor signaling pathway • retina development in camera-type eye • Ras protein signal transduction • cell population proliferation • cellular response to hypoxia • sensory perception of taste • GO:0072468 signal transduction • rhodopsin mediated signaling pathway • protein heterotrimerization • Wnt signaling pathway, calcium modulating pathway • protein folding • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2782	n/a
Ensembl	ENSG00000078369	n/a
UniProt	P62873	n/a
RefSeq (mRNA)	NM_002074 NM_001282538 NM_001282539	n/a
RefSeq (protein)	NP_001269467 NP_001269468 NP_002065	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GNB1 yw GNB1 a elwir hefyd yn G protein subunit beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GNB1.

• MRD42

Llyfryddiaeth

• "An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia. ". Oncogene. 2017. PMID 28650474.
• "Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans. ". Hum Mol Genet. 2017. PMID 28087732.
• "Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures. ". Am J Hum Genet. 2016. PMID 27108799.
• "Selection of Phototransduction Genes in Homo sapiens. ". Invest Ophthalmol Vis Sci. 2013. PMID 23868983.
• "Guanine nucleotide binding protein β 1: a novel transduction protein with a possible role in human breast cancer.". Cancer Genomics Proteomics. 2013. PMID 23603342.