SUB1

SUB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PCF, 2C62, 2PHE, 4USG
Dynodwyr
Cyfenwau	SUB1, P15, PC4, p14, SUB1 homolog, transcriptional regulator, SUB1 regulator of transcription
Dynodwyr allanol	OMIM: 600503 HomoloGene: 38218 GeneCards: SUB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • single-stranded DNA binding • DNA binding • GO:0001105 transcription coactivator activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • RNA binding • identical protein binding • sequence-specific double-stranded DNA binding Cydrannau o'r gell • nucleolus • extracellular exosome • transcription regulator complex • cnewyllyn cell Prosesau biolegol • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0009373 regulation of transcription, DNA-templated • transcription by RNA polymerase II • SMAD protein signal transduction • transcription, DNA-templated • positive regulation of transcription initiation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10923	n/a
Ensembl	ENSG00000113387	n/a
UniProt	P53999	n/a
RefSeq (mRNA)	NM_006713	n/a
RefSeq (protein)	NP_006704	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SUB1 yw SUB1 a elwir hefyd yn Activated RNA polymerase II transcriptional coactivator p15 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SUB1.

• P15
• PC4
• p14

Llyfryddiaeth

• "Human positive coactivator 4 (PC4) is involved in the progression and prognosis of astrocytoma. ". J Neurol Sci. 2014. PMID 25262015.
• "Sub1/PC4 a chromatin associated protein with multiple functions in transcription. ". RNA Biol. 2010. PMID 20305379.
• "A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4. ". J Biol Chem. 2017. PMID 28416612.
• "MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer. ". Oncogene. 2016. PMID 27270442.
• "PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites.". Oncogene. 2016. PMID 25961912.