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ResearchIn-Press PreviewCell biologyOncology
Open Access | 
10.1172/JCI180570
Hyaluronan network remodeling by ZEB1 and ITIH2 enhances the motility and invasiveness of cancer cells
Sieun Lee,1 Jihye Park,1 Seongran Cho,1 Eun Ju Kim,1 Seonyeong Oh,1 Younseo Lee,1 Sungsoo Park,2 Keunsoo Kang,3 Dong Hoon Shin,4 Song Yi Ko,5 Jonathan M. Kurie,6 and Young-Ho Ahn1
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Lee, S. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Park, J. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Cho, S. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Kim, E. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Oh, S. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Lee, Y. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Park, S. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Kang, K. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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Shin, D.
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1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Ko, S. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Kurie, J. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine and Inflammation-Cancer Microenvironment R, College of Medicine, Ewha Womans University, Seoul, Korea, Republic of
2Deargen Inc., Daejeon, Korea, Republic of
3Department of Microbiology, College of Science & Technology, Dankook University, Cheonan, Korea, Republic of
4Research Institute and Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Republic of
5UroGyn Efficacy Evaluation Center, Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
6Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by
Ahn, Y.
in:
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Published April 3, 2025 - More info
Copyright © 2025, Lee et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)