Glucose Oscillations Can Activate an Endogenous Oscillator in Pancreatic Islets
Fig 5
Model glycolytic oscillator recruitment.
A sinusoidal external glucose signal with baseline Ge = 15 mM, greater than the Hopf bifurcation at Gmid ≈ 14.5 mM, must have sufficiently large amplitude and period to activate the DOM glycolytic oscillator. (A) External glucose oscillations started with 0.5 mM amplitude and 5 min period (t < 60 min) trigger large-amplitude FBP oscillations only after the amplitude of glucose oscillations is increased to cross below Gmid ≈ 14.5 mM (t > 60 min). (B) Although glucose oscillations started with 1 mM amplitude and 1 min period (t < 60 min) cross below Gmid, they trigger large-amplitude FBP oscillations only after the period of glucose oscillations is increased to 5 min (t > 60 min).