The biophysical basis underlying the maintenance of early phase long-term potentiation
Fig 4
Variation of parameter values yields parameter sets for all three model versions such that E-LTP is maintained for several hours.
(A) The experimentally measured temporal course of E-LTP with and without the blockage of exocytosis [10, 15] is matched by all three model versions (basic, sLTP, cooperative) with corresponding parameter sets. Please note that lines overlie each other. (B,C) For the parameter sets used in (A), the LTP-induced increase of the binding rate of the models matches experimental data of CaMKII [21] (B), whereas the exocytosis event rate is too high for the basic and sLTP model and decays too slow for all three model versions compared to experimental data [12] (C). (D) The concentration of mobile receptors U increases to ≈300% of the baseline level for the basic and the sLTP model but only to ≈130% for cooperative model. (A-D) Shown are the upper 0.5% of 2000 randomly sampled parameter sets that match best with the experimental data in (A). For the matching we used the cost function described by Eq (9). Shades indicate standard deviation across parameter sets.