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Line 1: '''BAM15''' ~~BAM15~~ decreases [[hepatic]] [[fat]], decreases inflammatory [[lipids]], and has strong [[antioxidant]] effects. Hyperinsulinemic-euglycemic clamp studies show that BAM15 improves insulin sensitivity in multiple tissue types. Collectively, these data demonstrate that pharmacologic [[mitochondrial]] uncoupling with BAM15 has powerful anti-obesity and insulin sensitizing effects without compromising lean mass or affecting [[food]] intake.<ref>{{cite web \|title=Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice \|url=https://www.nature.com/articles/s41467-020-16298-2 \|website=nature \|accessdate=16 June 2020}}</ref> said John Kirwan, Ph.D., Executive Director of the Pennington Biomedical Research Center in Baton Rouge, Louisiana. "Halting the obesity epidemic requires new, more effective medications. This research represents a very promising step in the discovery process. We hope that in the not-too-distant future, BAM15 or related compounds will advance to clinical drug development and become a viable treatment option for patients with obesity."<ref>{{cite web \|title=A new study \|url=https://medicalxpress.com/news/2020-06-bam15-potential-treatment-obesity.html \|website=medicalxpress \|accessdate=16 June 2020}}</ref>▼ ▲said John Kirwan, Ph.D., Executive Director of the [[Pennington Biomedical Research Center]] in [[Baton Rouge]], [[Louisiana]]. "Halting the obesity epidemic requires new, more effective [[medications]]. This research represents a very promising step in the discovery process. We hope that in the not-too-distant future, BAM15 or related [[compounds]] will advance to clinical [[drug]] development and become a viable treatment option for [[patients]] with obesity."<ref>{{cite web \|title=A new study \|url=https://medicalxpress.com/news/2020-06-bam15-potential-treatment-obesity.html \|website=medicalxpress \|accessdate=16 June 2020}}</ref> == References ==

BAM15: Difference between revisions