BAM15 decreases hepatic fat, decreases inflammatory lipids, and has strong antioxidant effects. Hyperinsulinemic-euglycemic clamp studies show that BAM15 improves insulin sensitivity in multiple tissue types. Collectively, these data demonstrate that pharmacologic mitochondrial uncoupling with BAM15 has powerful anti-obesity and insulin sensitizing effects without compromising lean mass or affecting food intake.[1]
said John Kirwan, Ph.D., Executive Director of the Pennington Biomedical Research Center in Baton Rouge, Louisiana. "Halting the obesity epidemic requires new, more effective medications. This research represents a very promising step in the discovery process. We hope that in the not-too-distant future, BAM15 or related compounds will advance to clinical drug development and become a viable treatment option for patients with obesity."[2]
References
- ^ "Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice". nature. Retrieved 16 June 2020.
- ^ "A new study". medicalxpress. Retrieved 16 June 2020.