William Bruce may refer to:
- William Bruce (architect) (c. 1630-1710), Scottish architect
- William Bruce (cricketer) (1864-1925), Australian cricketer
- William Bruce (soldier) (1890-1914), posthumous recipient of the Victoria Cross
- William Cabell Bruce (1860-1946), Pulitzer-Prize-winning author and United States Senator
- William Speirs Bruce (1867-1921), Scottish explorer
- Axl Rose (b. 1962 as William Bruce Rose Jr.), lead singer of hard rock band Guns N' Roses
See also
- Bill Bruce, one of the men commemorated by the Bruce-Mahoney Trophy