3-Quinuclidinyl thiochromane-4-carboxylate is a research compound which is the most potent muscarinic antagonist known. Tests in vitro showed it to have a binding affinity over 1000 times more potent than 3-quinuclidinyl benzilate with a Ki of 2.47 picomolars (pM).[1][2]
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Formula | C17H21NO2S |
Molar mass | 303.42 g·mol−1 |
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editReferences
edit- ^ Cohen VI, Gibson RE, Reba RC (October 1987). "Synthesis and structure-activity relationships of new muscarinic antagonists". Journal of Pharmaceutical Sciences. 76 (10): 848–50. doi:10.1002/jps.2600761020. PMID 3430351.
- ^ Ball JC (2015). "Dual Use Research of Concern: Derivatives of 3-Quinuclidinyl Benzilate". Military Medical Science Letters. 84 (1): 2–41. doi:10.31482/mmsl.2015.001.