Cytoglobin
Template:PBB Cytoglobin is the protein product of CYGB, a human and mammalian gene.[1]
Cytoglobin is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It was discovered in 2001[2] and named cytoglobin in 2002[3]. It is thought to protect against hypoxia. The predicted function of cytoglobin is the transfer of oxygen from arterial blood to the brain.[4]
Applications
CYGB expression can be used as a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver.[5]
References
- ^ Cite error: The named reference
entrezwas invoked but never defined (see the help page). - ^ Kawada, N. (24 April 2001). "Characterization of a Stellate Cell Activation-associated Protein (STAP) with Peroxidase Activity Found in Rat Hepatic Stellate Cells". Journal of Biological Chemistry. 276 (27): 25318–25323. doi:10.1074/jbc.M102630200.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Burmester, T.; Ebner, B.; Weich, B.; Hankeln, T. (1 April 2002). "Cytoglobin: A Novel Globin Type Ubiquitously Expressed inVertebrate Tissues". Molecular Biology and Evolution. 19 (4): 416–421. doi:10.1093/oxfordjournals.molbev.a004096.
- ^ "Why Diving Marine Mammals Resist Brain Damage from Low Oxygen".
- ^ Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K, Kawada N (2014). "Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver". Lab. Invest. 94 (2): 192–207. doi:10.1038/labinvest.2013.135. PMID 24296877.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
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External links
- cytoglobin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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