Hideyo Noguchi

Hideyo Noguchi
野口 英世
Born	(1876-11-09)November 9, 1876 Inawashiro, Fukushima, Japan
Died	May 21, 1928(1928-05-21) (aged 51) Accra, Gold Coast
Resting place	Woodlawn Cemetery, New York City, US
Known for	syphilis Treponema pallidum
Scientific career
Fields	bacteriology
Japanese name
Kanji	野口 英世
Hiragana	のぐち ひでよ
Transcriptions Romanization Noguchi Hideyo

Hideyo Noguchi (野口 英世, Noguchi Hideyo, November 9, 1876 – May 21, 1928), also known as Seisaku Noguchi (野口 清作, Noguchi Seisaku), was a prominent Japanese bacteriologist who in 1911 discovered the agent of syphilis as the cause of progressive paralytic disease. Noguchi was one of the first Japanese scientists to gain international acclaim and recognition.

Early life

Noguchi Hideyo, whose childhood name was Seisaku Noguchi, was born to a family of farmers for generations in Inawashiro, Fukushima prefecture in 1876. When he was one and a half years old, he fell into a fireplace and suffered a burn injury on his left hand. There was no doctor in the small village, but one of the men examined the boy. "The fingers of the left hand are mostly gone," he said, "and the left arm, the left foot, and the right hand are burned; I don't know how badly."

In 1883, Noguchi entered Mitsuwa elementary school. Thanks to generous contributions from his teacher Kobayashi and his friends, he was able to receive surgery on his badly burned hand. He recovered about 70% mobility and functionality in his left hand through the operation.

Hideyo Noguchi and his mother Shika

Noguchi decided to become a doctor to help those in need. He apprenticed himself to Dr. Kanae Watanabe (渡部 鼎, Watanabe Kanae), the same doctor who had performed the surgery. He entered Saisei Gakusha, which later became Nippon Medical School. He passed the examinations to practice medicine when he was twenty years old in 1897.

Noguchi showed signs of great talent. Noguchi had three benefactors supporting him, Sakae Kobayashi, his elementary school teacher and father figure, Kanae Watanabe, the doctor who performed surgery on his hand, and his main benefactor, Morinosuke Chiwaki, the founder of the Tokyo Dental College, who helped fund his travel to America.

In 1898, he changed his first name to Hideyo after reading a novel by Japanese author Tsubouchi Shōyō about a college student whose character had the same name as him. The character in the story, Seisaku, was an intelligent medical student like Noguchi but became lazy and ruined his life.

Career

In 1900, Noguchi travelled on the America Maru to the United States. In part, his move was motivated by difficulties in obtaining a medical position in Japan, as its emphasis on expensive schooling and seniority put limits on his success. In addition to that, his employers were concerned his hand deformity would discourage potential patients. He felt moving to the United States, where talent counted for everything, he would be able to find more success.

Noguchi went to Philadelphia and obtained a job as a research assistant with Dr. Simon Flexner at the University of Pennsylvania in 1901 and later at the Rockefeller Institute of Medical Research. Flexner had to leave on business, but left Noguchi under guidance of Philadelphia physician Silas Weir Mitchell and dealt with the toxicology and immunology of venomous snakes. Noguchi had minimal experience with snake venom, but had seen researchers at the Kitasato Institute work with habu, a pit piper. Noguchi worked for three months. Flexner returned to see he had written a 250 page paper on snake venom. Noguchi had done it without knowing much on snake venom and entirely in English, a foreign language to him. Both presented their scientific findings to the National Academy of Science, being held in Philadelphia. Although, Dr. Mitchell did most of the talking about their findings while Noguchi handled the specimens and equipment used in the demonstration.

Dr. Mitchell said about Noguchi after their research concluded.

"It is thanks to the great efforts of this young man that I have been able to bring my thirty years of research to their final conclusion."

Dr. Mitchell praised Noguchi's work, becoming good friends with him. Although, Dr. Mitchell was concerned at how he would be accepted in larger Western society, but on July 9th, 1907 the University of Pennsylvania awarded Hideyo Noguchi an honorary degree. Their research paper appeared in the University of Pennsylvania's medical journal, becoming Noguchi's first official research publication. German researcher and scientist Paul Ehrlich even wrote to congratulate him. Dr. Mitchell had recommended Noguchi as a official researcher, which received funding for grants from Carnegie Institute and National Academy of Science of two thousand dollars.

Noguchi became fascinated with the concept of immunity which would become a theme of his life work through developing serums and vaccines. Eventually, Noguchi was invited to research at the Statens Serum Institute in Copenhagen, Denmark. He continued his research on serology and wrote several papers with fellow bacteriologist, Thorvald Madsen. His friendship continued with Madsen late into life.

In 1904, Noguchi started at the Rockefeller Institute under Simon Flexner. He and his peers learned from their work and from each other. In this period, a fellow research assistant in Flexner's lab was Frenchman Alexis Carrel, who would go on to win a Nobel Prize in 1912. He would later be nominated numerous times for a Nobel Prize, but never received one.

In 1905, the causative agent of syphilis, Treponema pallidum, was first identified by Fritz Schaudinn and Erich Hoffmann, but Noguchi would become the first person in the US to reproduce Treponema pallidum in 1906.

Hideyo Noguchi's Microscope used to study of the causal agent of syphilis at the Rockefeller Institute.

In 1909, Noguchi had procrastinated this after becoming distracted with syphilis, but published a lavishly produced monograph on snake venom, Snake Venoms: An Investigation of Venomous Snakes with Special Reference to the Phenomena of Their Venoms. Containing drawings from Noguchi and several photographs of specimens. In the preface, it stated,

“No single work in the English language exists at this time which treats of the facts of zoological, anatomical, physiological, and pathological features of venomous snakes, with particular reference to the properties of their venoms."

During his work with snakes, Noguchi complained about the feeding of live rabbits to the snakes in the lab. Noguchi felt this practice cruel, but this earned him a reputation as being oversensitive and sentimental for a scientist. Furthermore, Noguchi was known for his sloppiness at his work station as he left cigarette butts and used test tubes on it, but he told his advisors to look at the results, not the cigarettes.

Noguchi was prolific in his results, but he could get wrapped up in own thoughts for hours on end. His single year record for numbers of published papers was an unheard of nineteen submitted to journals. Noguchi's perfectionism and self reliance though made him refuse to accept help to the extent of distrusting others as he even washed his own test tubes and ground mixtures, even though his lab assistances could have taken care of these tasks. He explained, "I can't allow someone who doesn't know exactly what I'm doing here to interfere." Flexner described his work as "superhuman."

In 1909, he pioneered a new method known as the Butyric Acid Test for testing syphilis using sample fluid from the spinal column, hailed by the medical community for this achievement as it was a major step forward.

In Philadelphia, Noguchi had met Hajime Hoshi. Both had come from the Fukushima, but Hoshi had studied at Columbia University. Eventually, Hoshi returned to Japan and started a successful pharmaceutical business in Tokyo, but he continued to be friends with Noguchi. He used Noguchi's name as an advisor for his pharmaceutical company for the prestige, as Noguchi had begun receiving international recognition and acclaim, which he offered to compensate him for, but Noguchi told him to give it to his family in Fukushima to pay off their debts.

In 1910, Noguchi published the manuscript, Serum Diagnosis of Syphilis, which received international acclaim and became one of his most popular publications. In October 1910 and March 1911, he successfully isolated Treponema pallidum.

When interviewed about this moment, he said,

"All you need is enough test tubes, sufficient money, dedication, and hard work. . . and one more thing, you have got to be able to put up with endless failure."

When being compared to a genius, he said, there was no such thing as genius. There was only the willingness to work three, four, even five times harder than the next man.

Noguchi was known for some of his reckless behavior too. He accidentally swallowed some bacterial solution from sucking in a pipette with jaundice. He washed his mouth out with alcohol, doubtful he got rid of those millions of germs.

In 1913, Noguchi demonstrated a major discovery, the presence of Treponema pallidum in the brain of a progressive paralysis patient, proving that the spirochete was the cause of the neurosyphilis and the homogeneity between the mental and physical part of the disease. Dr. Noguchi's name is remembered in the binomial attached to another spirochete, Leptospira noguchii. One accomplishment that has been disputed was his pure culture of Treponema pallidum.

Personal life

Noguchi's personal life offers another side of his humanity. He secretly got married to Mary Loretta Dardis in April 10, 1912. Both were around the same age and came from a similar background of poverty, but her family were Irish immigrants. Mary, nicknamed Maize, called her husband, Hide. She would read to Noguchi as he worked at home. Noguchi was said to have loved her voice. His marriage was kept secret from his family, his benefactors, and his boss, Simon Flexner. Flexner opposed his marriage to an American. Noguchi was worried that his marriage would jeopardize his position and promotion at the Rockefeller Institute because she would have to be added to his pension. His marriage to most was not known until his death.

Noguchi and his wife found an apartment in 381 Central Park West. His neighbor was Ichiro Hori, a Japanese painter that would gain considerable fame as a photographer. Both had became friends and would spend a considerable amount of time having dinner, smoking cigars, and playing shogi and chess together.

His mentor, Kobayashi, granted Noguchi permission to call him “father", which Noguchi began addressing him in letters. He also was encouraging Noguchi to return and get a degree from a Japanese university and establish his future career in his birthplace.

In a letter from his mother Shika, who was notably illiterate, but learned to write in childish handwriting, “Please come home soon, please come home soon, please come home soon, please come home soon.” His mother worked as a midwife in Japan, but he promised to send her about ten dollars every month to his family. After his mother's health had worsened, he sailed to Japan on September 5th, 1915 to visit her and he had won the Imperial Prize. He was met with reporters and crowds on the dock. He saw his mentors Chiwaki and Kobayashi at the Imperial Hotel and presented them with golden watches. When he arrived to see his mother, he showed her a photograph of his wife who approved of her and soon both were laughing. He spent ten days with her, but afterwards returned to the United States, and this trip was his last trip in Japan. In November 1918, his mother Shika died.

Hideyo Noguchi's Shandaken house on Old Route 42

In 1917, Noguchi's good bill of health had declined. He had suffered from typhoid fever worsened by the fact he had eaten four dozen oysters and slept very little. Mary had to call an ambulence since he refused to go, but eventually, he was hospitalized at Mount Sinai Hospital. His fever was severe and those around him feared the worst. Hoshi gave him money for his treatment. Later, he had appendicitis alongside his wife, Mary. While recovering, Noguchi and his wife took a four hour train ride to the Glenbrook Hotel in Shandaken located in the Catskills Mountains. The small hamlet with less than a hundred people reminded him of his hometown of Inawashiro with the mountains similar to the Bandai foothills and a local lake like that of Lake Inawashiro.

Hideyo Noguchi and his friends on the porch of his Shandaken home

Noguchi decided to purchase land, approximately two hectares, and build a house in Shandaken, becoming one of the largest landowners in the hamlet. The construction was completed around June 15th, 1918. He built and designed his home alongside the Esopus river where he would fish and spend most of his summers in 1918, 1922, and 1925 to 1927.

Hideyo Noguchi using color photography technique autochrome lumière

In 1925, his wife, Mary, three brothers came to visit. In addition, his friend Ichiro Hori and Japanese students studying abroad visited him at his Shandaken property.

Noguchi was gifted oil paints from his neighbor, Ichiro Hori, which he brought to Shandaken. His paintings hang in the Hideyo Noguchi Memorial Museum.

It was said that there is no researcher who likes photography more than Dr. Noguchi. For instance, Noguchi was an amateur photographer, and he might have been one of the first color photographs of the Japanese. He achieved this through using the autochrome lumière, an early color photograph technique. He stated this in a letter, dated August 8th, 1914, to his childhood mentor, Sakae Kobayashi.

Luetin experiment and the antivivisectionists

In 1911 and 1912 at the Rockefeller Institute in New York City, Noguchi was working on a syphilis skin test, which could provide a useful diagnostic procedure to complement the Wassermann test in the detection of syphilis.

Professor William Henry Welch, Board of Scientific Directors at the Rockefeller Institute for Medical Research, urged Noguchi to conduct human trials. The subjects were gathered from clinics and hospitals across New York City. In the experiment, the doctors given the tests injected an inactive product of syphilis, called luetin, under the skin on the upper arm of the patient.

Skin reactions were studied, as they varied among healthy subjects and syphilis patients, based on the disease's stage and its treatment. The lutein test gave a positive reaction almost 100 percent for congenital and late syphilis. Of the 571 subjects, 315 had syphilis. The remaining subjects were controls; some of which were orphans between the ages of 2 and 18 years. Most were hospital patients being treated for diseases, such as malaria, leprosy, tuberculosis, and pneumonia, and the subjects did not did not realize they were being experimented on and could not give consent.

Critics at the time, mainly from the anti-vivisectionist movement, noted that the Rockefeller Institute violated the rights of vulnerable orphans and hospital patients. There was concern among anti-vivisectionists that the test subjects had contracted syphilis from the experiments, but were proven to be false.

In Dr. Noguchi's defense, Noguchi had performed tests on animals to ensure the safety of the luetin test. Rockefeller Institute business manager Jerome D. Greene wrote a letter to the Anti-Vivisection Society, which had pointed out that Noguchi had tested it on himself and his fellow researchers before administering it.

In a letter to District Attorney Charles S. Whitman, Greene said

"What public institution would not welcome a harmless and painless test which would enable it to decide in the case of every person admitted whether that person was afflicted with a venereal disease or not?"

Much of the information came from sensationalized newspapers, which did not consult medical professionals. Greene mentioned the steps taken to ensure the sterility. His explanation was considered a demonstration of the care that doctors were taking in research. In addition, Noguchi might have received more criticism due to his race with racist metaphors such as yellow peril being perpetuated. One of these newspaper described him as "the Oriental admirer of the fruits of Western civilization."

In May 1912, the New York Society for the Prevention for Cruelty to Children asked the New York district attorney to press charges against Noguchi, but he declined. Although, none of subjects were infected with syphilis, the Rockefeller Institute tested on patients without consent.

Even though none of the subjects were injured in the experiment, Hideyo Noguchi had committed a wrong, it was 'a wrong without injury'. Albert Leffingwell, a physician, social reformer, and advocate for vivisectionist restrictions, said in response to Jerome D. Greene.

"If insurance could have been given that the luetin test implied no risk of any kind, might not the Rockefeller Institute have secured any number of volunteers by the offer of a gratuity of twenty or thirty dollars as a compensation for any discomfort that might be endured?"

At the time of the luetin experiment, consent in medical science was by no means customary. For instance, the fathers of microbiology, Robert Koch, operated medical concentration camps in Africa in 1906 to 1907 to find a cure for sleeping sickness, and ended up blinding some of his patients, and Louis Pasteur experimented on 9-year-old Joseph Meister without a medical license even though it was a success and was suspected to have lied about conducting animal trials.

The United States did not develop sufficient consensus about unethical human experimentation for laws to be passed until the late 20th century, which brought about informed consent and the rights of patients.

Later work

After his recent trip to Japan, Noguchi was inspired to tackle Weil's disease and Rocky Mountain spotted fever, similar to Tsutsugamushi, which was first isolated and found in Japan. One of the reasons for him for choosing these diseases was that deaths were common among rice planters, farmers, and miners in Japan.

Later, Noguchi showed discontent working on not as well known diseases, noted by his Japanese assistant at the Rockefeller Institute named Seinai Akatsu, a cousin of Hajime Hoshi. Noguchi began losing his temper and scolding his assistant. He wanted to work on something more of a threat.

In a letter to Flexner, he wrote,

"Somehow I cannot manage to find enough time to sit quietly and think over things calmly and reflect upon many things and phases in life. I seem to be chasing something all the time, perhaps an acquired habit or rather the lack of poise".

Out of the laboratory, Akatsu said he was a different and more open person. He would even invite him to restaurants and speak Japanese with him—something he never did at the Rockefeller Institute since his arrival in America.

Nonetheless, Noguchi did not seem satisfied. Eventually, he decided to focus his attention on yellow fever, which some of his colleagues died researching. In 1918, Noguchi traveled throughout Central America and South America working with the International Health Board to conduct research to develop a vaccine for yellow fever, and to research Oroya fever, poliomyelitis and trachoma.

Hideyo Noguchi along the Rio Grande dissecting a crocodile

In 1923, Noguchi was credited with producing an effective antiserum against Rocky Mountain Spotted Fever.

While working on the diseases, Noguchi said,

"Whether I succeed or not is another matter, but the problem is worth trying."

Noguchi was a bacteriologist and believed that yellow fever was caused by bacteria instead of a virus, which would later be proven wrong. During his career, viruses were not well known and studied, having been discovered by two scientists in 1892. He worked for much of the next ten years attempting to prove this. Noguchi thought he had even developed a vaccine against "yellow fever". His work was criticized as taking an inaccurate approach for yellow fever that was contradictory to contemporary research. Later it would be understood he had confused yellow fever with leptospirosis, his vaccine was successfully used to treat the latter disease. After Noguchi's death in 1928, the electron microscope was developed in 1931, which could clearly identify and prove yellow fever was a virus, even though skeptics had started to understand it was earlier.

Death

The bust of the Japanese scientist and doctor Hideyo Noguchi was inaugurated on June 22, 2018 outside the Crystal Palace in Guayaquil

Following the death of British pathologist Adrian Stokes of yellow fever in September 1927, it became increasingly evident that yellow fever was caused by a virus, not by the bacillus Leptospira icteroides, as Noguchi believed.

Feeling his reputation was at stake, Noguchi hastened to Lagos to carry out additional research. However, he found the working conditions in Lagos did not suit him. At the invitation of Dr. William Alexander Young, the young director of the British Medical Research Institute, Accra, Gold Coast (modern-day Ghana), he moved to Accra and made this his base in 1927.

However, Noguchi proved a very difficult guest and by May 1928 Young regretted his invitation. Noguchi was secretive and volatile, working almost entirely at night to avoid contact with fellow researchers. Possibly his erratic and irresponsible behavior was caused by the untreated syphilis with which he was diagnosed in 1913, and which may have progressed to neurosyphilis. The diaries of Oskar Klotz, another researcher with the Rockefeller Foundation, describe Noguchi's temper and behavior as erratic and bordering on the paranoid. His methods were haphazard.

According to Klotz, Noguchi inoculated huge numbers of monkeys with yellow fever, but failed to keep proper records. Noguchi might have believed himself immune to yellow fever, having been inoculated with a vaccine of his own development.

Despite repeated promises to Young, Noguchi failed to keep infected mosquitoes in their secure containers. In May 1928, having failed to find evidence for his theories, Noguchi was set to return to New York after spending six months in Africa, but was fallen ill in Lagos.

He boarded his ship to sail home, but on 12 May was put ashore at Accra and taken to a hospital with yellow fever. After lingering for some days, he died on 21 May.

In a letter home, Young states, "He died suddenly noon Monday. I saw him Sunday afternoon – he smiled – and amongst other things, said, “Are you sure you are quite well?" "Quite." I said, and then he said "I don’t understand."

Seven days later, despite exhaustive sterilisation of the site and most particularly of Noguchi's laboratory, Young himself died of yellow fever.

Legacy

Statue of Hideyo Noguchi in Ueno Park

Hideyo Noguchi Memorial Museum

Noguchi was influential during his lifetime. Although, his later research was not able to reproduce many of his claims, including having discovered the causes of polio, rabies, trachoma, and yellow fever. His mental state deteriorated as he suffered from neurosyphilis, prone to amnesia and personality changes. His finding that Noguchia granulosis causes trachoma was questioned within a year of his death, and overturned shortly thereafter. Alongside his identification of the rabies pathogen, because the medium he invented to cultivate bacteria was seriously prone to contamination. A fellow Rockefeller Institute researcher said that Noguchi "knew nothing about the pathology of yellow fever" and criticized him for being unwilling to issue retractions for his claims. Another criticism are the flaws inside the Rockefeller Institute's system of peer review.

Noguchi's most famous contribution is his identification of the causative agent of syphilis (the bacteria Treponema pallidum) in the brain tissues of patients with partial paralysis due to meningoencephalitis. Other lasting contributions include the use of snake venom in serums, his development on antiserums for Rocky Mountain spotted fever, his manuscripts and diagnostics test, the identification of the leishmaniasis pathogen and of Carrion's disease with Oroya fever. He published over 200 papers on various infectious diseases, one of the most prolific scientists, and gave lecture tours throughout Europe. In 1921, he was elected as a member of the American Philosophical Society. Although, his claim to have grown a culture of syphilis though is considered irreproducible.

In the 21st century, the Nobel Foundation archives were opened for public inspection and research. Noguchi was nominated several times for the Nobel Prize in Physiology or Medicine: in 1913–1915, 1920, 1921 and 1924–1927. Some of Noguchi's prize nominations and work on a pure culture of syphilis and yellow fever received scrutiny.

Selected works

• 1904: The Action of Snake Venom Upon Cold-blooded Animals.

Washington, D.C.: Carnegie Institution. [OCLC 2377892]

• 1909: Snake Venoms: An Investigation of Venomous Snakes with Special Reference to the Phenomena of Their Venoms.

Washington, D.C.: Carnegie Institution. [OCLC 14796920]

• 1911: Serum Diagnosis of Syphilis and the Butyric Acid Test for Syphilis.

Philadelphia: J. B. Lippincott. [OCLC 3201239]

• 1923: Laboratory Diagnosis of Syphilis: A Manual for Students and Physicians.

New York: P. B. Hoeber. [OCLC 14783533]

Honors during Noguchi's lifetime

Noguchi was honored with Japanese and foreign decorations. He received honorary degrees from a number of universities.

Noguchi was self-effacing in his public life, and he often referred to himself as "Funny Noguchi" as noted in Times Magazine. When Noguchi was awarded an honorary doctorate at Yale, William Lyon Phelps observed that the kings of Spain, Denmark and Sweden had conferred awards, but "perhaps he appreciates even more than royal honors the admiration and the gratitude of the people."

• Kyoto Imperial University, Doctor of Medicine, 1909.
• Knight of the Order of Dannebrog, 1913 (Denmark).
• Commander of the Order of Isabella the Catholic, 1913 (Spain).
• Commander of the Order of the Polar Star, 1914 (Sweden).
• Tokyo Imperial University, Doctor of Science, 1914.
• Order of the Rising Sun, Gold Rays with Rosette, 1915.
• Imperial Award, Imperial Academy (Japan), 1915.
• Central University of Ecuador, 1919, (Ecuador).
• National University of San Marcos, 1920, (Peru)
• Medicine School of Merida, "Doctor Honoris Causa en Medicina y Cirugía", 1920 (México)
• University of Guayaquil, 1919, Ecuador.
• Yale University, 1921, (United States).
• Knight of the Legion of Honour of France, 1924
• Senior fifth rank in the order of precedence, Japanese government, 1925

Posthumous honors

Hideyo Noguchi on the ¥1,000 banknote

The grave of Hideyo Noguchi in Woodlawn Cemetery

Noguchi's remains were returned to the United States and buried in Woodlawn Cemetery in the Bronx, New York City.

In 1928, the Japanese government awarded Noguchi the Order of the Rising Sun, Gold and Silver Star, which represents the second highest of eight classes associated with the award.

In 1979, the Noguchi Memorial Institute for Medical Research (NMIMR) was founded with funds donated by the Japanese government at the University of Ghana in Legon, a suburb north of Accra.

In 1981, the Instituto Nacional de Salud Mental (National Institute of Mental Health) "Honorio Delgado - Hideyo Noguchi" was founded with founds of the Peruvian Government and the JICA (Japan International Cooperation Agency) in Lima - Perú.

Dr. Noguchi's portrait has been printed on Japanese 1000-yen banknotes since 2004. In addition, the house near Inawashiro where he was born and brought up is preserved. It is operated as part of a museum to his life and achievements.

Noguchi's name is honored at the Centro de Investigaciones Regionales Dr. Hideyo Noguchi at the Universidad Autónoma de Yucatán.

A 2.1 km street in Guayaquil, Ecuador downtown is named after Dr. Hideyo Noguchi.

Hideyo Noguchi Africa Prize

The footstone of Hideyo Noguchi in Woodlawn Cemetery, New York City

The Japanese Government established the Hideyo Noguchi Africa Prize in July 2006 as a new international medical research and services award to mark the official visit by Prime Minister Jun'ichirō Koizumi to Africa in May 2006 and the 80th anniversary of Dr. Noguchi's death. The Prize is awarded to individuals with outstanding achievements in combating various infectious diseases in Africa or in establishing innovative medical service systems. The presentation ceremony and laureate lectures coincided with the Fourth Tokyo International Conference on African Development in late April 2008. In 2009, the conference venue was moved from Tokyo to Yokohama as another way of honoring the man after whom the prize was named. In 1899, Dr. Noguchi worked at the Yokohama Port Quarantine Office as an assistant quarantine doctor.

The Prize is expected to be awarded every five years. The prize has been made possible through a combination of government funding and private donations.

See also

• List of medicine awards
• Max Theiler - completed Noguchi's work, yellow fever vaccine (1926)
• Human experimentation in the United States
• Tōki Rakujitsu - Japanese film

References

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• D'Amelio, Dan. Taller Than Bandai Mountain: The Story of Hideyo Noguchi. New York: Viking Press. ISBN 978-9997502384 (cloth) [OCLC 440466]
• Dolman, C E (1977). Hideyo Noguchi (1876-1928): his final effort. Clio medica (Amsterdam, Netherlands). Vol. 12. pp. 131–45. ISSN 0045-7183. PMID 72623.
• Flexner, James Thomas. (1996). Maverick's Progress. New York: Fordham University Press. ISBN 978-0-8232-1661-1 (cloth)
• Flexner Simon (1929). "Hideyo Noguchi: A Biographical Sketch". Science. 69 (1800): 653–660. Bibcode:1929Sci....69..653F. doi:10.1126/science.69.1800.653. PMID 17737643.
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• Kita, Atsushi. (2005). Dr. Noguchi's Journey: A Life of Medical Search and Discovery (tr., Peter Durfee). Tokyo: Kodansha. ISBN 978-4-7700-2355-1 (cloth)
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• Lederer, Susan E. Subjected to Science: Human Experimentation in America before the Second World War, Johns Hopkins University Press, 1995/1997 paperback
• Liu, Pinghui V (September 2004). "Noguchi's contributions to science". Science. 305 (5690): 1565. doi:10.1126/science.305.5690.1565a. PMID 15361606. S2CID 11983110.
• Masaki, T (1978). "[Hideyo Noguchi and oral spirochaete]". Shikai Tenbo = Dental Outlook. 51 (6): 1265. ISSN 0011-8702. PMID 394992.
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• Noguerea, J J (October 2007). "Hideyo Noguchi and trachoma (Inawashiro, Japan, 1876--Accra, Ghana, 1928)". Archivos de la Sociedad Española de Oftalmología. 82 (10): 661–2. doi:10.4321/s0365-66912007001000014. ISSN 0365-6691. PMID 17929213.
• Sri Kantha, S. "Hideyo Noguchi's research on yellow fever (1918–1928) in the pre-electron microscopic era", Kitasato Archives of Experimental Medicine, April 1989; 62(1): 1–9.
• Takazoe, Ichiro (October 2002). "[Achievement by Hideyo Noguchi]". Nippon Naika Gakkai Zasshi. 91 (10): 2887–90. ISSN 0021-5384. PMID 12451642.
• Takeda, Yoshifumi (November 2003). "[Great Japanese bacteriologists in the Meiji, Taisho and Showa era]". Nippon Saikingaku Zasshi. 58 (4): 645–55. doi:10.3412/jsb.58.645. ISSN 0021-4930. PMID 14699855.
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External links

• Noguchi Memorial Institute for Medical Research, University of Ghana, Legon
• Japanese Government Internet TV: streaming video, "Hideyo Noguchi Africa Prize," 2007/04/26 (5 mins.)
• Fukushima Prefecture: "The Dreamer, Hideyo Noguchi," slide show Archived 2015-08-10 at the Wayback Machine
• Cabinet Office, Government of Japan: Hideyo Noguchi Africa Prize
• Japan Society for the Promotion of Science (JSPS): Purpose and Description of the Noguchi Prize
• National Diet Library: NDL portrait
• Yomiuri Shimbun: Noguchi -- slightly less than 90% name recognition amongst primary school students in Japan, 2008.