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Flupentixol/melitracen

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Flupentixol/melitracen
Combination of
FlupentixolTypical antipsychotic
MelitracenTricyclic antidepressant
Clinical data
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
  (verify)

Flupentixol/melitracen (trade name Frenxit, Franxit, Placida, Deanxit, Anxidreg, Danxipress, Mocalm) is a combination of two psychoactive agents flupentixol and melitracen. It is designed for short term usage only. It is produced by Lundbeck.[1]

Flupentixol is a thiazolyl (thioanthracene) antipsychotic, and melitracen is a tricyclic antidepressant. Low dose Flupentixol (0.5mg-3mg) has antidepressant and anti-anxiety effects, while melitracen has antidepressant effect. The mixture of the two components is used to treat mild to moderate mental disorders.

Flupentixol acts as a dopamine 1 and 2 receptor antagonist and melitracen acts in similar way to other tricyclic antidepressants blocking the reuptake of serotonin and norepinephrine in presynaptic terminals.

Medical uses

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[2]

Route of administration

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Trade Name Active Ingredient Routes Dose(s) Manufacturer
Depixol Flupentixol decanoate Deep Intramuscular Injection 20 mg/mL Solution[3]

(Amount injected varies depending on prescribed dose)

Lundbeck
Deanxit Flupentixol, Melitracen Oral, Tablet form 0.5 mg Flupentixol, 10 mg Melitracen[4]

(per tablet)

Lundbeck

This table does not represent an exhaustive list, but demonstrates the various methods this medication is able to be administered. Flupentixol and melitracen is produced by numerous pharmaceutical companies worldwide, with many using oral tablets as the preferred route.

Dosage

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Adult: Per tablet contains flupentixol 0.5 mg and melitracen 10 mg: 1 tablet in the morning and at midday. May double morning dose in severe cases. Not to exceed 4 tablets daily.[citation needed]

Elderly: Per tablet contains flupentixol 0.5 mg and melitracen 10 mg: 1 tablet in the morning. For severe cases: 1 tablet in the morning and at midday.[citation needed]

Contraindications

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Circulatory collapse, depressed level of consciousness due to any cause, Coma. Severe depression requiring hospitalization or electroconvulsive therapy. Not recommended for use in states of excitement or overactivity.

Adverse reactions

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Unsafe in porphyria. Caution when used in patients with epilepsy; Parkinson's disease; narrow angle glaucoma; prostatic hypertrophy; hypothyroidism; hyperthyroidism; liver disease; cardiac disease or arrhythmias; severe respiratory disease; renal failure; myasthenia gravis; phaeochromocytoma. Patients with hypersensitivity to thioxanthenes or other antipsychotics. Close monitoring for changes in behaviour, suicidal thoughts or clinical worsening during the initial part of the treatment is recommended. May impair control of diabetes; monitor blood glucose in diabetics.

Drowsiness, dry mouth, constipation, vomiting, dyspepsia, diarrhoea, abdominal pain, nausea, flatulence. Extrapyramidal effects, especially in the initial phase of the treatment. Tachycardia, palpitations, prolonged QT interval, hypotension. Thrombocytopenia, neutropenia, leukopenia, agranulocytosis. Dyspnoea, myalgia, muscle rigidity, micturition disorder, urinary retention. Increased appetite and weight. Abnormal glucose tolerance and LFTs. Insomnia, depression, nervousness, agitation, decreased libido.

Drug Interactions

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Increased risk of adverse effects when used with alcohol. May potentiate the effects of general anaesthetics and anticoagulants, and prolong the action of neuromuscular blockers. May increase anticholinergic effects of atropine and drugs with anticholinergic activity. May increase risk of neurotoxicity when used with sibutramine or lithium. Avoid concurrent usage with drugs that cause QT prolongation or cardiac arrhythmias. May inhibit metabolism of TCAs. May antagonise effects of adrenaline and sympathomimetics, and reverse antihypertensive effects of guanethidine.

Pharmacology

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Mechanism of action

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Flupentixol inhibits dopamine-mediated effects by blocking postsynaptic dopamine receptors in the CNS.

Melitracen is a TCA with anxiolytic properties. At low doses, it has activating properties. It is also a bipolar thymoleptic.

Pharmacokinetics

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Absorption: Flupentixol: Readily absorbed in the GI tract.

Distribution: Flupentixol: >95% bound to plasma proteins; widely distributed in the body and crosses the blood brain barrier.

Metabolism: Flupentixol: Extensively hepatic metabolism.

Excretion: Flupentixol: Excreted in urine and faeces in the form of many metabolites.

ATC Classification

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N06AA14 - melitracen ; Belongs to the class of non-selective monoamine reuptake inhibitors. Used in the management of depression.

N05AF01 - flupentixol ; Belongs to the class of thioxanthene derivatives antipsychotics.

Society and culture

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Brand names

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Brand names include:

  • Pentoxol.m (scotmann pharmaceuticals Pakistan)
  • Sensit (Eskayef Bangladesh Ltd.)
  • Renxit (Renata Ltd.)
  • Melixol (Square Pharmaceuticals Ltd.)
  • Melanxit (Organic Health Care Ltd.)
  • Benzit (Bio-Pharma Ltd.)
  • Leanxit (ACME Laboratories Ltd.)
  • Danxipress (Vickmans Lab Ltd.)
  • Amilax (Amico Lab Ltd)
  • Angenta (Healthcare Pharmaceuticals Ltd.)
  • EXZILOR (SUN PHARMA LABORATORIES LTD.)
  • Mocalm (Swiss Pharmaceutical Co. Ltd. 瑞士藥廠股份有限公司新市廠)

See also

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References

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  1. ^ Sweetman SC, ed. (2009). "Preparations". Martindale: The complete drug reference (36th ed.). London: Pharmaceutical Press. p. 2607. ISBN 978-0-85369-840-1.
  2. ^ "Flupentixol". go.drugbank.com. Retrieved 2024-07-20.
  3. ^ "Depixol 20 mg/ml solution for injection - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Retrieved 2024-07-20.
  4. ^ "Deanxit, Flupentixol + Melitracen". Singapore: MIMS.

Further reading

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