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MY-5445

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MY-5445
Names
Preferred IUPAC name
N-(3-Chlorophenyl)-4-phenylphthalazin-1-amine
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.163.900 Edit this at Wikidata
EC Number
  • 636-069-4
UNII
  • InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)
    Key: CEHQLKSLMFIHBF-UHFFFAOYSA-N
  • InChI=1/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)
    Key: CEHQLKSLMFIHBF-UHFFFAOYAQ
  • C1=CC=C(C=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC(=CC=C4)Cl
Properties
C20H14ClN3
Molar mass 331.80 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

MY-5445 is a relatively specific phosphodiesterase 5 inhibitor.[1][2]

See also

[edit]
  • Vatalanib — a structurally related angiogenesis inhibitor

References

[edit]
  1. ^ Nagendran, J; Archer, SL; Soliman, D; Gurtu, V; Moudgil, R; Haromy, A; St. Aubin, C; Webster, L; Rebeyka, IM; Ross, DB; Light, PE; Dyck, JR; Michelakis, ED (17 July 2007). "Phosphodiesterase Type 5 is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility" (PDF). Circulation. 116 (3): 238–48. doi:10.1161/circulationaha.106.655266. PMID 17606845. S2CID 7612061.
  2. ^ Hagiwara, M; Endo, T; Kanayama, T; Hidaka, H (February 1984). "Effect of 1-(3-Chloroanilino)-4-phenylphthalazine (MY-5445), a Specific Inhibitor of Cyclic GMP Phosphodiesterase, on Human Platelet Aggregation". The Journal of Pharmacology and Experimental Therapeutics. 228 (2): 467–71. PMID 6141286.
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