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Small nucleolar RNA SNORD14

From Wikipedia, the free encyclopedia
Small nucleolar RNA SNORD14
Identifiers
SymbolSNORD14
Alt. SymbolsU14
RfamRF00016
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

In molecular biology, U14 small nucleolar RNA (U14 snoRNA) is a non-coding RNA required for early cleavages of eukaryotic precursor rRNAs. In yeasts, this molecule possesses a stem-loop region (known as the Y-domain) which is essential for function. A similar structure, but with a different consensus sequence, is found in plants, but is absent in vertebrates.[1] In human there are two closely related copies called SNORD14A and SNORD14B that are expressed from the intron of their host gene ribosomal protein Rps13.

References

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  1. ^ Samarsky DA, Schneider GS, Fournier MJ (June 1996). "An essential domain in Saccharomyces cerevisiae U14 snoRNA is absent in vertebrates, but conserved in other yeasts". Nucleic Acids Research. 24 (11): 2059–66. doi:10.1093/nar/24.11.2059. PMC 145897. PMID 8668536.
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