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Practice Editing Here (Nov 15th in-class Wiki session work)

• This is a place to practice clicking the "edit" button and practice adding references (via the citation button).

Task:

1. Find a peer-reviewed journal article on PubMed. Practice inserting your citation in the above space using the "cite" tool
2. Choose one "B-level" medical article on Wikipedia from the following list: https://wp1.openzim.org/#/project/Medicine/articles?quality=B-Class&importance=High-Class
3. Practice editing live on Wikipedia by finding a typo in the text or improving the clarity/readability of a sentence by adjusting a few words in a sentence.

Assignment # 3- please post an anonymous copy here!

1. Suggested Change #5: "Diagnosis" section, "Classification" heading.

• Suggested change: All amyloid fibril proteins start with the letter "A" followed by the protein suffix (and any applicable specification). See below for a list of amyloid fibril proteins which have been found in humans:

Fibril protein	Precursor protein	Target Organs	Systemic and/or localized	Acquired or hereditary
AL	Immunoglobulin light chain	All organs, usually except CNS	S, L	A, H
AH	Immunoglobulin heavy chain	All organs except CNS	S, L	A
AA	(Apo) serum amyloid A	All organs except CNS	S	A
ATTR	Transthyretin, wild type Transthyretin, variants	Heart mainly in males, lung, ligaments, tenosynovium PNS, ANS, heart, eye, leptomeninges	S S	A H
Aβ2M	β2-microglobulin, wild type β2-microglobulin, variants	Musculoskeletal system ANS	S S	A H
AApoAI	Apolipoprotein A I, variants	Heart, liver, kidney, PNS, testis, larynx (C terminal variants), skin (C terminal variants)	S	H
AApoAII	Apolipoprotein A II, variants	Kidney	S	H
AApoAIV	Apolipoprotein A IV, wild type	Kidney medulla and systemic	S	A
AApoCII	Apolipoprotein C II, variants	Kidney	S	H
AApoCIII	Apolipoprotein C III, variants	Kidney	S	H
AGel	Gelsolin, variants	Kidney, PNS, cornea	S	H
ALys	Lysozyme, variants	Kidney	S	H
ALECT2	Leukocyte chemotactic factor-2	Kidney, primarily	S	A
AFib	Fibrinogen a, variants	Kidney, primarily	S	H
ACys	Cystatin C, variants	CNS, PNS, skin	S	H
ABri	ABriPP, variants	CNS	S	H
ADanb	ADanPP, variants	CNS	L	H
Aβ	Aβ protein precursor, wild type Aβ protein precursor, variant	CNS CNS	L L	A H
AαSyn	α-Synuclein	CNS	L	A
ATau	Tau	CNS	L	A
APrP	Prion protein, wild type Prion protein variants Prion protein variant	CJD, fatal insomnia CJD, GSS syndrome, fatal insomnia PNS	L L S	A H H
ACal	(Pro)calcitonin	C-cell thyroid tumours Kidney	L S	A A
AIAPP	Islet amyloid polypeptidec	Islets of Langerhans, insulinomas	L	A
AANF	Atrial natriuretic factor	Cardiac atria	L	A
APro	Prolactin	Pituitary prolactinomas, aging pituitary	L	A
AIns	Insulin	Iatrogenic, local injection	L	A
ASPCd	Lung surfactant protein	Lung	L	A
ACor	Corneodesmosin	Cornified epithelia, hair follicles	L	A
AMed	Lactadherin	Senile aortic, media	L	A
AKer	Kerato-epithelin	Cornea, hereditary	L	A
ALac	Lactoferrin	Cornea	L	A
AOAAP	Odontogenic ameloblast-associated protein	Odontogenic tumours	L	A
ASem1	Semenogelin 1	Vesicula seminalis	L	A
AEnf	Enfurvitide	Iatrogenic	L	A
ACatKe	Cathepsin K	Tumour associated	L	A
AEFEMP1e	EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	Portal veins, Aging associated	L	A

20ogk1 (talk) 03:29, 18 November 2021 (UTC)

2. Rationale: The International Society of Amyloidosis (ISA) Nomenclature Committee meets every 2 years to discuss and update classifications. Due to the ongoing research surrounding amyloids, it is critical for Wikipedia to reflect the most up-to-date types of amyloid fibril proteins and their associated areas of deposit.

3. Controversy: No controversy was identified with this area as the previous nomenclature did not have a reference.

4. Critique of Sources: The main strength of the source is that the ISA currently stands as the premier resource concerning amyloid nomenclature consensus. The authors come from all around the world, and represent independent and unbiased expertise. It is also the most up-to-date and comprehensive list I found available. The weakness of the source is that the list of precursor proteins is difficult to understand for those without a background in medicine or bioscience. I have also removed the previous table's column attempting to relate each fibril to a disease, as this was not properly referenced. This is somewhat unavoidable when discussing amyloidosis, as many relationships between amyloid deposits and diseases are still not entirely understood.

5. Wikipedia Talk Page: The above recommended change has been posted to the Amyloidosis "talk" page on Wikipedia.

What to post on the Wikipedia article talk page (part of assignment 3)

• This will also be covered on Nov 15th in class. Your group should use the below template to share an outline of your proposed improvements (including your new wording and citations). Article talk pages are not places to share your assignment answers. The Wikipedia community will be more interested in viewing your exact article improvement suggestions including where you plan to improve the article (which section), what wording you suggest, and the exact citation (Note: all citations must meet WP:MEDRS)
• You will not be able to paste citations directly from your sandbox to talk pages (unless you are interested in editing/learning Wiki-code in the "source editing" mode). We suggest re-adding your citations on the talk page manually (using the cite button and populating the citation by pasting in the DOI, website, or PMID). You will have to repeat this process yet again when you edit the actual article live.
• Talk Page Template: Wikipedia:CARL Medical Editing Initiative/Fall 2021/Talk Page Template