User:Kamieyeofori/sandbox
Kamieyeofori (talk) 17:23, 6 November 2014 (UTC)
Clinical Significance.
[edit]Haptotaxis plays a major role in the efficient healing of wounds.[1] [2] When corneal intergrity is compromised epithelial cells quickly cover the damaged area by proliferation and migration(Haptotaxis). In the Stroma, Keratocytes within the wounded area undergo apoptosis leaving the stroma devoid of cells that must be replaced and the keratocytes surrounding the wounded area proliferate and become fibroblast that migrate to fill the stromal wounded area. This creates a healthy enviroment with myofibroblasts and ECM. This is known as light backscattering or subepithial haze.[3]
When there is injury to an epithethial cells heptataxis occurs and this is highly influenced by the cells velocity . This velocity is influenced by direction of cell motility. Cells migrate easily and quickly in packs so when one cell moves, the rest follow in response to the gradient and initial cell movement. Mechanical effects like the buildup of tension in the may play an important role for both division as well as motility of cells in tissue.Cite error: There are <ref> tags on this page without content in them (see the help page).[4]
Kamieyeofori (talk) 18:30, 6 November 2014 (UTC)
- ^ Blanco-Mezquita, Jose; Hutcheon, Audrey E.K; Zieske, James D. (January 28, 2013). "Role of Thrombospondin-1 in Repair of Penetrating Corneal Wounds". Invest ophthalmology: 7. doi:10.1167/iovs.13-11710.
- ^ Basan, Markus; Elgeti, Jens; Hannezo, Edouardo; Rappel, Wouter-Jan; Levine, Herbert (9/9/2012). "lignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing". Proceedings of the National Academy of Sciences of the United States of America PNAS, Proceedings of the National Academy of Sciences (PNAS 2013 110:2452-2459): 8. Retrieved 6 November 2014.
{{cite journal}}: Check date values in:|date=(help) - ^ Blanco-Mezquita, Jose; Hutcheon, Audrey E.K; Zieske, James D. (January 28, 2013). "Role of Thrombospondin-1 in Repair of Penetrating Corneal Wounds". Invest ophthalmology: 7. doi:10.1167/iovs.13-11710.
- ^ Basan, Markus; Elgeti, Jens; Hannezo, Edouardo; Rappel, Wouter-Jan; Levine, Herbert (9/9/2012). "lignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing". Proceedings of the National Academy of Sciences of the United States of America PNAS, Proceedings of the National Academy of Sciences (PNAS 2013 110:2452-2459): 8. Retrieved 6 November 2014.
{{cite journal}}: Check date values in:|date=(help)