XPNPEP2

XPNPEP2
Identifiers
Aliases	XPNPEP2, AEACEI, APP2, X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, X-prolyl aminopeptidase 2
External IDs	OMIM: 300145; MGI: 2180001; HomoloGene: 37766; GeneCards: XPNPEP2; OMA:XPNPEP2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	129,769,536 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	47,225,858 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; jejunal mucosa; ; kidney tubule; ; glomerulus; ; human kidney; ; duodenum; ; metanephric glomerulus; ; gastric mucosa; ; right coronary artery; ; left coronary artery;
	Top expressed in
	intestinal villus; ; jejunum; ; right kidney; ; ileum; ; proximal tubule; ; embryo; ; esophagus; ; duodenum; ; embryo; ; gray matter layer of cerebellum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; aminopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloaminopeptidase activity;
Cellular component	anchored component of membrane; extracellular exosome; membrane; extracellular region; plasma membrane; cytoplasm;
Biological process	proteolysis; C-terminal protein lipidation;
	Sources:Amigo / QuickGO
Orthologs
	7512
	170745
	ENSG00000122121
	ENSMUSG00000037005
	O43895
	B1AVD1
	NM_003399
	NM_001289729; NM_133213
	NP_003390
	NP_001276658; NP_573476
	Wikidata
View/Edit Human	View/Edit Mouse

Xaa-Pro aminopeptidase 2 is an enzyme that in humans is encoded by the XPNPEP2 gene.^[5]^[6]^[7]

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122121 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037005 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Venema RC, Ju H, Zou R, Venema VJ, Ryan JW (Dec 1997). "Cloning and tissue distribution of human membrane-bound aminopeptidase P". Biochim Biophys Acta. 1354 (1): 45–8. doi:10.1016/s0167-4781(97)00126-7. PMID 9375790.
^ Sprinkle TJ, Stone AA, Venema RC, Denslow ND, Caldwell C, Ryan JW (Apr 1999). "Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25". Genomics. 50 (1): 114–6. doi:10.1006/geno.1998.5302. PMID 9628831.
^ ^a ^b "Entrez Gene: XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound".

Vanhoof G, De Meester I, Goossens F, et al. (1992). "Kininase activity in human platelets: cleavage of the Arg1-Pro2 bond of bradykinin by aminopeptidase P". Biochem. Pharmacol. 44 (3): 479–87. doi:10.1016/0006-2952(92)90439-P. PMID 1510698.
Cottrell GS, Hyde RJ, Hooper NM, Turner AJ (1998). "The cloning and functional expression of human pancreatic aminopeptidase P". Biochem. Soc. Trans. 26 (3): S248. doi:10.1042/bst026s248. PMID 9765967.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Prueitt RL, Ross JL, Zinn AR (2000). "Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene". Cytogenet. Cell Genet. 89 (1–2): 44–50. doi:10.1159/000015560. PMID 10894934. S2CID 46232057.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Molinaro G, Duan QL, Chagnon M, et al. (2007). "Kinin-dependent hypersensitivity reactions in hemodialysis: metabolic and genetic factors". Kidney Int. 70 (10): 1823–31. doi:10.1038/sj.ki.5001873. PMID 17003818.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122121 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037005 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9375790-5] Venema RC, Ju H, Zou R, Venema VJ, Ryan JW (Dec 1997). "Cloning and tissue distribution of human membrane-bound aminopeptidase P". Biochim Biophys Acta. 1354 (1): 45–8. doi:10.1016/s0167-4781(97)00126-7. PMID 9375790.

[pmid9628831-6] Sprinkle TJ, Stone AA, Venema RC, Denslow ND, Caldwell C, Ryan JW (Apr 1999). "Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25". Genomics. 50 (1): 114–6. doi:10.1006/geno.1998.5302. PMID 9628831.

[entrez-7] "Entrez Gene: XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading