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ENZYME

ENZYME entry: EC 2.4.1.259

Accepted Name
dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
Alternative Name(s)
Dol-P-Man:Man6GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase
Reaction catalysed
an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)
Comment(s)
  • The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate.
  • Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl beta-D-mannosyl phosphate.
  • ALG9 mannosyltransferase catalyzes the addition of two different alpha-1,2-mannose residues - the addition of alpha-1,2-mannose to Man6GlcNAc2-PP-dolichol (EC 2.4.1.259) and the addition of alpha-1,2- mannose to Man8GlcNAc2-PP-dolichol (EC 2.4.1.261).
  • Formerly EC 2.4.1.130.
Cross-references
BRENDA2.4.1.259
EC2PDB2.4.1.259
ExplorEnz2.4.1.259
KEGG Ligand Database for Enzyme Nomenclature2.4.1.259
IUBMB Enzyme Nomenclature2.4.1.259
MEDLINEFind literature relating to 2.4.1.259
MetaCyc2.4.1.259
Rhea expert-curated reactions2.4.1.259
UniProtKB/Swiss-Prot
Q9FZ49, ALG9_ARATHP54002, ALG9_CAEELQ9H6U8, ALG9_HUMAN
Q8VDI9, ALG9_MOUSEQ9P7Q9, ALG9_SCHPOP53868, ALG9_YEAST

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