Expasy logo

ENZYME

ENZYME entry: EC 6.1.1.27

Accepted Name
O-phosphoserine--tRNA ligase
Alternative Name(s)
O-phosphoseryl-tRNA ligase
SepRS
Reaction catalysed
tRNA(Cys) + O-phospho-L-serine + ATP = O-phospho-L-seryl-tRNA(Cys) + AMP + diphosphate
Comment(s)
  • In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 for the direct Cys-tRNA(Cys) formation, Cys-tRNA(Cys) is produced by an indirect pathway, in which EC 6.1.1.27 ligates O-phosphoserine to tRNA(Cys), and EC 2.5.1.73 converts the produced O-phospho-L-seryl- tRNA(Cys) to Cys-tRNA(Cys).
  • The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism.
  • Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73.
  • Formerly EC 6.1.1.n2.
Cross-references
BRENDA6.1.1.27
EC2PDB6.1.1.27
ExplorEnz6.1.1.27
KEGG Ligand Database for Enzyme Nomenclature6.1.1.27
IUBMB Enzyme Nomenclature6.1.1.27
MEDLINEFind literature relating to 6.1.1.27
MetaCyc6.1.1.27
Rhea expert-curated reactions6.1.1.27
UniProtKB/Swiss-Prot
O30126, SEPS_ARCFUA6UVW6, SEPS_META3Q8TUH7, SEPS_METAC
Q0W0T4, SEPS_METARA7I4Y4, SEPS_METB6Q46D71, SEPS_METBF
Q12XG0, SEPS_METBUQ2FSR2, SEPS_METHJQ59054, SEPS_METJA
Q8TY66, SEPS_METKAA2SQV5, SEPS_METLZA4FYB1, SEPS_METM5
A9A794, SEPS_METM6A6VJZ5, SEPS_METM7Q8PX39, SEPS_METMA
A3CXN8, SEPS_METMJQ6LZE1, SEPS_METMPB8GJL9, SEPS_METPE
O27545, SEPS_METTHA0B632, SEPS_METTPA6USJ0, SEPS_METVS

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-